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Advanced Prostate Cancer
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ASCO Genitourinary Cancers Symposium (PectaSol-C modified citrus pectin)

There has been a recent thread on modified citrus pectin [MCP], & I have an old post thart reviewed the literature. For most of us MCP means PectaSol.

The study was on 35 "non-metastatic biochemically relapsed prostate cancer ... patients (pts)". Treatment (tx): "4.8 grams X 3/day"

"62% (n = 21) had a stabilization/decrease of PSA, and negative scans, at 6 mos, and entered the second 12 mos tx phase."

"A stabilization or improvement (increase) of PSA doubling time was noted in 79% (n = 27) of pts. Disease progression at 6 mos was noted in 38% (n = 13: PSA only 29%, n = 10; PSA and scans 9%, n = 3)."

"The present study suggests a potential benefit of P-MCP ..."

-Patrick

clinicaltrials.gov/show/NCT...

14 Poster Session (Board #A20), Thu, 11:30 AM-1:00 PM and

5:15 PM-6:15 PM

Effect of pectasol-c modified citrus pectin (P-MCP) treatment (tx) on PSA dynamics in non- metastatic biochemically relapsed prostate cancer (BRPC) patients (pts): Results of a prospective phase II study.

Daniel Keizman, Moshe A. Frenkel, Avivit Peer, Eli Rosenbaum, David Margel, David Leonid Sarid, Victoria Neiman, Maya Gottfried, Natalie Maimon, Ilan Leibovitch, Hadas Dresler, Isaac Eliaz; Meir Medical Center, Kfar-Saba, Israel; Rambam Health Care Campus, Haifa, Israel; Davidoff Cancer Center, Petah Tikva, Israel; Rabin Medical Center, Petah Tikva, Israel; Ichilov Medical Center, Tel Aviv, Israel; Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel; Lung Cancer Unit, Meir Medical Center, Kfar-Saba, Israel; Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar-Saba, Israel; Amitabha Medical Clinic and Healing Center, Santa Rosa, CA

Background: 30% of pts with localized PC will have a biochemical relapse post local tx. The optimal tx of these pts remains elusive. While androgen deprivation therapy is effective in reducing PSA level, its long-term benefit on survival remain undefined, and it is associated with significant cumulative toxicities.Thus, evaluation of new non-toxic compounds in this pt population is warranted. P-MCP is a competitive inhibitor of galectin-3, a carbohydrate-binding protein, which is known to be involved in cancer pathogenesis. Pre-clinical and clinical data suggest that P-MCP is active in PC. We aimed to evaluate the safety and PSA dynamics of tx with P-MCP in pts with BRPC.

Methods: Pts with non-castrate non-metastatic BRPC were enrolled in a prospective phase 2 study of tx with oral P-MCP, at 4.8 grams X 3/day for 6 months (mos). Pts that did not progress clinically, biochemically (PSA), and radiologically, at 6 mos, were treated for subsequent 12 mos. Sample size provided 85% power to assess a decrease in PSA progression rate from 80% (natural history) to 40% (P-MCP tx) at 6 mos.

Results: The study was initiated in June 2013. 35 pts were enrolled. Median age was 74 years. Treatment of the primary tumor consisted of surgery in 11% (n = 4), radiation in 69% (n = 24), and both in 20% (n = 7). No pt had tx related grade 3/4 toxicity. One patient withdrew his consent after 1 mos. Of the 34 pts analyzed, 18% (n = 6) had grade 1 toxicity. 62% (n = 21) had a stabilization/decrease of PSA, and negative scans, at 6 mos, and entered the second 12 mos tx phase. A stabilization or improvement (increase) of PSA doubling time was noted in 79% (n = 27) of pts. Disease progression at 6 mos was noted in 38% (n = 13: PSA only 29%, n = 10; PSA and scans 9%, n = 3).

Conclusions: The present study suggests a potential benefit of P-MCP tx on progression of BRPC. P-MCP tx is safe. Clinical trial information: NCT01681823.

29 Replies
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Patrick you know this is one of my main supplements. There is the Original Paper from the Israeli Trials--that predates any serious trial work in the USA---If you can find them as I do not know where I filed them----they looked at other data--one was really interesting in curtailing angiogenesis, via the Galactin-3 interference from the modified pectin.

I use 5 grams 3 times a day---just had one--one yet to go before bed.

Nalakrats

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Nala, where do you get your pectin? Do you use capsules or powder? How long have you been taking it and are you seeing results? Sorry for all the questions. I'm really interested in this because I have non metastatic recurrent cancer after treatment, which is the type of patient they tried it on.

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I have been on it 2 years---5 grams---3 times a day. It is hard to tell what caused my results since I use the Kitchen Sink approach to my Supplements, along with my ADT program, which is on hold as I am on vacation, from main drugs. Was the pectin a part of the good news to go on vacation?---IMO---yes--as the MCP, has shown from Israeli trials to prevent Galectin-3 that Pca cells use to stick together---and if they cannot stick together, then angiogenesis becomes difficult.

I get at either Amazon, or Vitacost---just saved 30 dollars with my last order this week---as I used Amazon reward points---I play one against the other for the best price---each time I buy.

Nalakrats

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Are the veggie caps just as good re. MCP.

Rich

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In my opinion they are not. I follow the protocol of the Israeli Trial Phase 2,3--and the USA Trial in Phase 3 currently, or recently finished. Three, 5 gram scoops a day, of the powder.

Nalakrats

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Which brand? Do you put it in enteric capsules?

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I use the original ecoNugenics---and not the capsules. I only use the Powder as per the Clinical trials--I do not dilute--I throw the 5 gram scoop to the back of my throat, and then chase it with a couple of ounces of water on an empty stomach---3 times a day for a total of 15 grams a day.

Nalakrats

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wouldn't it be easier to put them into enteric capsules?

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The company also puts P-3 in capsules. So you can buy that way.

Nalakrats

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Usually I put myself n enteric capsules, it's cheaper and I have better control. But I'm sure you take it in powder for a reason. Just because of the trial or do you have an idea why it could work better that way?

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This is getting too complicated, in how to swallow something. I take it in Pwd form, to follow the Clinical Trials, as I mentioned. Been doing it this way 3 years!

Nalakrats

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The easiest way for me, is to pour some water into a glass, add the powder without stirring & set aside an hour or so. The powder doesn't readily mix with water when stirred, but somehow does over time. A quick stir before swallowing. Not unpleasant & no clumps in the stomach.

-Patrick

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Patrick,

I gather you are not actually at the SF ASCO GU meeting, but is anyone reading this actually there?

Also...

Next week ASCO is having its annual survivorship conference. This year it is in Orlando. Is anyone reading this planning on being there? I have been to one of those meetings previously and there was not much presented on PCa. But I'm going again this year and it would be nice to meet up with other PCa patients, who might be planning on attending.

Richard W.

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Patrick,

I believe in the benefits of P-MCP; however, I can't remember the negative inference regarding one of my diseases: diabetes, Hypertension or,Kidney disease. I knew, I personally could not take it.

Rich

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I have chronic kidney disease and looked for negatives but didn't find any. In fact I found one article that said it's good for kidneys. So it must be something else.

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Thank you, I may have misread a study 7 years ago. I am going to use the product after reading a link Patrick sent me see below.

Rich

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Rich,

"With no known side effects and a GRAS (generally recognized as safe) designation, MCP is clearly a powerful tool for a proactive, integrative approach to kidney health."

holisticprimarycare.net/top...

-Patrick

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Thank you, Patrick. I may have misread an earlier study. I am convinced of its merits. Thank you for the link. Do you order from the outfit in CA? What do you mix the scoop of MCP with. How about low sodium V-8 juice? You may have extended my life.

Rich

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I use about 8 oz hot water, stir and let it sit for a bit to allow the pect c to dissolve. It can be a bit clumpy. Stir a couple more time and when the water is cool enough - over the lips and through the gums... Even then you might get some clumps.

My Pect-C is the lime infused powder from Econugenics.

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Rich,

This stuff seems to get more expensive everytime I look: $96.86 at VitaCost & iHerb for 454g. Dr. Eliaz is not one of my heroes.

Here is my technique. I pour a few ounces of water in a glass & then add the scoop without stirring. Forget about it for an hour or so. It needs time to dissolve.

If you stir up front, it does not dissolve & you get clumps on the stirrer & the sides of the glass.

Stir & swallow on an empty stomach.

-Patrick

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Do you take it once a day?

The scoop how many oz, does it hold?

Rich

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The scoop is small - 5g - & comes with the product.

Instructions are 1 scoop, 3X daily. I have only ever done once/day.

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Thank you

Rich

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Does the scoop come woth the container?

Rich

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I’ve been taking it daily for probably 8+ years. Can’t say it dropped/stabilized my PSA, but I’m still looking down at my cannabis plants, and not up at their roots!

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Thank you for the advice. Do you order it from Amazon or Vitacost or from the outfit in CA?

Rich

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My wife is a Nurse Practitioner and she has an account with Econugenics. I get my PectaSol-C and Mycophyto Mushroom powder directly from them. Cost a lot less that way.

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Thank you for the information.

Rich

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I take my 5 grams, 3x a day. My thought is best case this increases doubling time, worse case it keeps me from snacking during the day, cause I need to take the mid-day dose on an empty stomach. Have not see any side effects

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