Galectin-3 Level and Modified Citrus Pectin

[Polaris1]

Diagnosed with Gleason 8 with PSA of 14. Following RP in October 2018, PSA rose to 0.53 and Axumin scan found one pelvic lymph node with PCa. Had SRT in September-October 2019, and my PSA is currently undetectable.

I am very interested in the studies that have been done with MPC (Modified Citrus Pectin) indicating the possibility of delaying metastasis. I just had my Galectin-3 level tested for the first time, and it is 9.9 ng/ml, which I understand is a favorable level.

I just started using MCP (5 g, 3X per day), and I am interested in hearing what other men have experienced regarding the impact of MCP on Galectin-3 levels.

[Hidden]

I did it religiously my first two years. I went into remission after Rt and double adt . I did much alt med plus still on the nutrients and diet from a naturalpathic Md. He put me on the MCP.. The way that I look at it the more good stuff that I try the more a chance that something will stick . I also did 50 mgs of vitamin c IV’s twice weekly for a year and a half . Everyone , my family friends Mo . Ro, and pc specialist all had no faith and told me not to do high dose they Rt . I did it any way . Uro told me i was gone in 36 months no matter what I did . Pc specialist told me Rt on top of adt was the nail in my coffin for having an erection ever again . Wrong again.. on both accounts. My wife’s love and care for me is still the best medicine. I’m lucky to be alive . I too was stage#4 gl.4+4 . Non op ...Idid orchioectomy 9-17 allowing me to stop Lupron shots for life. Still taking four pink pills that stop

T production from the adrenal ..Many here do not belive in naturalpathic medicine. I do . Remember that our heart degrade with treatments . Daily exercise is needed. Keep rolling amigo ... Scott

[Kaliber in reply to Hidden]

Rite on ... 💪💪💪💪 👍👍👍 🌻🌼🌸🦋

[pjoshea13]

This is 3 years old but might be useful:

healthunlocked.com/advanced...

-Patrick

[Polaris1 in reply to pjoshea13]

Patrick, thanks for this information. Do you believe, as some have suggested, that the effectiveness of taking MCP can be measured indirectly by monitoring Galectin-3 levels? Does anyone have data correlating MCP use to reduction in Galectin-3 levels?

[pjoshea13 in reply to Polaris1]

I'm not aware of any PCa info. Perhaps look at non-PCa studies? Here's the most recent:

pubmed.ncbi.nlm.nih.gov/318...

-Patrick

[Polaris1 in reply to pjoshea13]

Patrick, thanks.

Some of these papers regarding PCa and non-PCa diseases state the following (or similar): Modified citrus pectin is an effective inhibitor of galectin-3, which is correlated with tumor progression, proliferation, angiogenesis, and apoptosis.

The most recent paper that you listed (February 2020) reports that MCP failed to show a benefit for knee osteoarthritis. However, “The low baseline serum Gal-3 levels [6-8 ng/ml] in this OA patient cohort likely reduced the therapeutic response to blocking Gal-3 function with MCP."

Since my Galection-3 is only 9.9 ng/ml, perhaps it is too low to be reduced further with MCP?

[pjoshea13 in reply to Polaris1]

I don't know how that knee dosage (caps) compares to the suggested scoop dose. Might be a dose issue.

[HopingForTheBest1 in reply to pjoshea13]

6 capsules is equivalent to one scoop, and much more convenient

[Polaris1]

Thanks for your replies to pjoshea13's post. Back to my original question about the impact of MCP on Galectin-3 levels... Do you or anyone else have data relevant to this question? To be more specific, does anyone know if MCP actually reduces the Galectin-3 level? And can we monitor Galectin-3 levels as a measure of MCP effectiveness? Is there a target level for Galectin-3 for men with PCa? And since my Galectin-3 is only 9.9 ng/ml at this point, can I still expect benefit from MCP?

[Polaris1]

Nalakrats, thank you for your further explanations. You touched on my basic question when you referred to "the reduction of Galectin-3". Can I infer that you do not monitor your Galectin-3? If so, is that because your Galectin-3 level is low - or because you do not feel it is useful to monitor its level? Like you, I am making an intuitive choice to use MCP but also looking for a way to monitor the effectiveness of MCP. I will look for the papers on the Israeli Trials.

[Claud68]

prnewswire.com/news-release...

That's about the results of the IIb clinical trial. Is there another trial phase III in Israel ongoing?

[Polaris1 in reply to Claud68]

Claud68, thanks for the timely reference to the phase IIb trial results.

[Bigblock]

Hey dude you sound like the perfect person to experiment yourself since you can get your Galectin-3 tested and see if you can reduce it, when I researched it about 2-3 years ago they were saying that Galectin-3 levels were a mark of longevity, the lower they are the longer you live generally, now this could be purely coincidentally, I used to take it till the price went through the roof here in the UK, I was stage 3 with a slowly rising PSA, I stopped taking it and now I’m stage 4 with a quickening PSA, now that could be purely natural progression or did it have an effect at slowing it down, I had no Galectin-3 levels done so I have no data to refer to, I wish I had of carried on taking it as I might be in a better situation now but that’s ifs, buts and maybes, you on the other hand can get yours tested, from the research I did I would say take it if you can afford it because it can only help, I understand there are no negatives except price, you might be able to give some valuable insight from for people here, I take my hat off to everybody on this site trying to help each other, well done to all of you.

[Polaris1 in reply to Bigblock]

Bigblock, thanks for the encouragement. Yes, I have started using MCP and intend to monitor Galectin-3 as well as other parameters. Hopefully this will contribute in some small way to our knowledge about PCa.

[Vany4]

Anecdotal evidence - my husband’s recurrent psa was doubling every 3 months, and Sloan Kettering does not want to treat him until his psa reaches 3 for adt or 4 for psma scan. Feeling restless and worried, I read about the recent MCP study and he started taking it (redommended 3 doses a day) about 8 weeks ago. Went to the primary care dr for another psa reading. It was 1.74 in early December, and the reading in February, was 1.62. Not only did the doubling time decrease, but the psa slightly declined. Now this could have been from a different reason, but our bet is it’s the MCP.

[Polaris1 in reply to Vany4]

Vany4, thanks for sharing this information. Let's hope the MCP is contributing to the improvement.