Just found this new study. There doesn't appear to be any down-sides to taking it that I see.
Anyone take Modified Citrus Pectin? - Advanced Prostate...
Anyone take Modified Citrus Pectin?
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john_in_pa
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The subject has come up many time. Might be worth searching. Here's one of mine from 5 years ago:
healthunlocked.com/advanced...
-Patrick
I thought this exceprt from Patricks study was worth highlighting. Mike “Commercially available fractionated pectin powder (FPP) induced apoptosis (approximately 40-fold above non-treated cells) in both cell lines ... Conversely, citrus pectin (CP) and the pH-modified CP, PectaSol, had little or no apoptotic activity."
I suspected that FPP was made by Thorne. I contacted Debra Mohnen & requested the full-text of the paper. A very nice lady & an expert on pectin - not cancer - she said that she had been surprised by the interest the study had stirred up in men with PCa. & yes, the Thorne product was used.
I contacted Thorne & found that the head of research was unaware of the study, let alone with the paper. Thorne seemed clueless & eventually dumped the product in favor of ... PectaSol. Crazy.
The difference? Chain fragmentation in PectaSol is achieved by changing the pH, whereas Thorne used heat.
An update to the Thorne debacle:
Thorne eventually abandoned it's own product & began selling the other one. I imagine that the profit margin was attractive. Dr Isaac Eliaz has done a great job of keeping the prices high on his products for many years.
econugenics.com/pages/dr-is...
Sounds like a serious Business Opportunity?
Yes! If only we could persuade Nalakrats to come out of retirement.
How many oncologists read the 2007 paper - it was published in Glycobiology? None?
Debra Mohnen (& Crystal Jackson) are pectin experts - not cancer specialists. But maybe they know of an alternative source?
See the Discussion in the full text:
sci-hub.st/10.1093/glycob/c...
-Patrick
Rhubarb?
"Various pectin fractions were screened in vitro. Modified rhubarb pectin (EMRP) was identified as the most potent inhibitor of galectin-3 and compared to the well-known modified citrus pectin (MCP). Our findings were validated in a mouse model of myocardial fibrosis, which was induced by angiotensin II (Ang II) infusion."
pubmed.ncbi.nlm.nih.gov/348...
-Patrick
Patrick, do you think the Pectasol-C works? A lot of guys are taking it. Where did it show that the fractionated commercial stuff works and not the Pectasol-C ? Why would Nal take it off it doesn’t work?
Pectasol-C is what they used in this new study. Here's the full text...
The science seems compelling:
"Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD)" [1]
"Galectin-3 (Gal-3) is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis." [1]
Galectin-3 isn't all bad, but: "Given galectin-3's broad biological functionality, it has been demonstrated to be involved in cancer, inflammation and fibrosis, heart disease, and stroke. [1]
"The roles of galectins and galectin-3, in particular, in cancer have been heavily investigated.[30] Of note, galectin-3 has been suggested to play important roles in cancer metastasis." [1]
There are many sources of pectin, a non-digestible carbohydrate. The chains can be very long - much too long to be taken up from the gut. Hence, they must be broken up by some mysterious process. (I doubt that 24 hours in a home blender would cut it, but what's so special about the process that Eliaz can continue to charge such a high amount?) The pectin fragments are taken up by the gut, are present in the blood and, presumably inactivate galectin-3 that is on the surface of cells & prevent the metastasis of circulating cancer cells. What's not to like?
The Eliaz product has been around in one form or another for 30 years. In spite of the high price, countless men have used it. I have spent a small fortune on MCP. I jumped ship in 2007 & used the Thorne FCP product until they switched to MCP. I have some MCP, but I have lost my youthful enthusiasm & use it only sporadically.
So, in theory, if MCP were to be used from diagnosis, metastasis could be prevented in heavily screened men. Even in men diagnosed with advanced PCa, metastasis might be limited to pre-existing sites.
Why aren't doctors convinced? With almost 30 years as a well-known supplement, why are statistics lacking?
Where is BigPharma?:
"Galecto Biotech in Sweden is focused on developing drugs targeting galectin-3 to treat fibrosis, specifically idiopathic pulmonary fibrosis. Galectin Therapeutics in the United States is also targeting galectins for clinical applications. Preclinical studies demonstrate that inhibition of galectin-3 significantly reduces portal hypertension and fibrosis. Galectin Therapeutics galectin-3 inhibitor GR-MD-02 (belapectin) is currently in human clinical trials for nonalcoholic steatohepatitis (NASH) and for increasing the effectiveness and reducing side effects of cancer immunotherapy." [1]
Perhaps the cardiovascular benefit will restore my enthusiasm?:
"Chronic heart failure has been found to be indicated by a galectin-3 tests, using the ARCHITECT immunochemistry platform developed by BG Medicine and marketed by Abbott, helping to determine which patients are most at risk for the disease. This test is also offered on the VIDAS platform marketed by bioMérieux. Pecta-Sol C binds to galectin-3 binding sites on the surfaces of cells as a preventative measure created by Isaac Eliaz in conjunction with EcoNugenics.
"Galectin-3 is upregulated in patients with idiopathic pulmonary fibrosis. The cells that receive galectin-3 stimulation (fibroblasts, epithelial cells, and myofibroblasts) upregulated the formation of fibrosis and collagen formation. Fibrosis is necessary in many aspects of intrabody regeneration. The myocardial lining constantly undergoes necessary fibrosis, and the inhibition of galectin-3 interferes with myocardial fibrogenesis. A study concluded that pharmacological inhibition of galectin-3 attenuates cardiac fibrosis, LV dysfunction, and subsequent heart failure development." [1]
-Patrick
Is this the older product? Still available?
Thanks John in PA for helping illuminate this subject. Spyder54 is it your opinion from your research that the PectaSol is not effective? A lot of us are wading through the data on supplements for PC. Much of stuff is frankly over my head but I thank Nalakrats and others for shedding light on this.
Rolphs. No. I am fascinated by this. If you read Nalakrats response, taking it 3x per day (powder form may have the best efficacy, and read the research from PJ, it appears that this fruit Pectin (possibly Rhubarb Pectin EMRP) may break down the glue that allows PCa to colonize and metasticize. I want to do this! These men are much smarter than me. I am taking so many supplements already, but this seems worth pursuing.
Metastisis is what eventually kills us. If we can stop or slow down, I am all about it!!!
The biz opp I mentioned was the company making the best fruit pectin out there stopped, and focused on a lesser mixture, without even knowing the power of its Cancer fighting ability.
Best,
Mike
Ps: I need to research which brand, price, availability to add.
Did Thorne read the study and show it to their pharmacists?
How about this product? Is it still the old version you write about?
Is this the product?
drvitaminsolutions.com/prod...
Thorne's old product used "Fractionated" to distinguish it from Eliaz's "Modified", IMO.
When they dumped their own, they continued to advertize the other as "Fractionated". Classic bait & switch. Fooled me & others. I realized right away what they had done when I bought some - the word "Modified" appears beneath "Fractionated" on the label. Notice also that it is described as "pH-modified citrus pectin".
Thanks very much. I was getting pushback in another forum on this, with some saying, "Hey, look, it's still available."
Patrick, do we have consensus on which product in the Market today is most similar to Thornes hypofractionated (FPP) Citrus Pectin, and where to purchase? It seems there are many men with interest, including me. I believe there is benefit in adding this 3x daily before meals.Much appreciation for your long term, organized Research,
My best to you and yours,
Mike
Hi Mike,
I am not aware of such a product. I think we are stuck with Eliaz & his high price MCP.
-Patrick
Patrick, what about the Pomegranite Fruit Pectin Powder you mentioned?Mike
Mike, You mean rhubarb? Researchers got hold of it, but I can't find a source. -Patrick
Patrick,Sorry. Yes Rhubarb not Pomegranite.
This seems to be a fair summary of the subject:
metagenicsinstitute.com/blo...
Note the reference to ripe papaya:
researchgate.net/publicatio...
Ripening-induced chemical modications of papaya pectin inhibit cancer cell proliferation
Thanks Patrick. I went to the website that makes petrosolC and they lost for patent numbers claiming that they use the original formula from the study. Maybe they are lying but with the cardio benefits etc, the benefit probably outweighs the cost.
I take modified citrus pectin daily based upon recommendations from Nalakrats. Nalakrats is probably the modified fruit pectin guru on the group. I’d guess he might jump in here and answer questions you might have or share some sage information and advice if he’s available. You could PM him as well. I use the capsules daily, many probably use the powder since it’s a better value price wise. In either case, modified fruit pectin is fairly pricey as supplements go.
Searching “ Nalakrats and pectin “ would probably produce all the info you seek.
💪💪💪❤️❤️❤️
I take a teaspoon first thing every morning with water on an empty stomach. I’ve read the studies and figure it can’t hurt in preventing or slowing down micro metastasis’s, and I’ve had no apparent SE’s after two years.
My Husband also takes it, as recommended by Nalakrats. Hope its doing what its supposed to. No issues with it either.
Thank for the feedback everyone. I blend MCP powder into my hot coffee with an electric hand mixer. How much does everyone take? I believe the studies used 5 mg 3x day.
Yes I take it having read about it in Nalakrats posts. I take the powder version on an empty stomach
Anyone know of a good source?
I've been taking the powder from Swanson Vitamins. It's their own brand. It's much cheaper than Pectasol-C . I've been taking Swanson vitamins for years and find their quality to be very good.
Where is a good source for MCP (Modified Citrus Pectin)???
I for one would be interested in an update--on new MCP findings.
THANKS!!!
The one item consistently taken for 5 1/2 years since diagnosed. Pectasol-C
The report said 4.8 grams 3x a day?
You can order from econugenics. You can get a discount with a subscription. Three one-pound jars every three months is $266.
Just don't mistake that P for an R. BTW while I have your attention.
Greetings john_in_pa,
Please tell us your bio. Age? Location? When diagnosed? Treatment(s)? Treatment center(s)? Scores Psa/Gleason? Medications? Doctor's name(s)?
All info is voluntary, but it helps us help you and helps us too. When you respond, copy and paste it in your home page for your use and for other members’ reference.
THANK YOU AND KEEP POSTING!!!
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 01/14/2022 6:56 PM EST
Thanks! 57 years old. Live outside of Philadelphia. Diagnosis May 2021. PSA 5.7, G9, PI-RADS 5, Mets to pelvic LN. Triple play treatment... Eligard+Zytiga/VMAT IMRT/HDR Brachy boost. Completed Rad tx Nov. 2021. 2 years minimum on ADT. Treated at Fox Chase Cancer Center in Phildalphia, RO Dr. Eric Horwitz, MO Daniel Geynisman.
From a dasher to an underscorer..... Thank you for your quick and detailed response. Good that it's in your home page. We have several members located in, I hate to say the name "Philly".....So maybe you can link up with them and talk about how bad your sport teams are😁......Anyway you've come to the right place for information and comradery..... Stay well and keep posting.....
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 01/14/2022 8:01 PM EST
What do you think about what spider and Patrick said above, about fractionated commercial version bring what was used in the study, and that Pectasol-C was not effective?
I’m going to share this study with my oncologists.
Thanks John in PA for refreshing our focus! A little of this, a little of that, and we just may (should) make progress at extending life. Mike
St Pete
I took one bottle but most trials seemed to have some connection to the doc who sells it.
This is the most economical brand that I've found. Swanson discount codes can also found via a Google search.swansonvitamins.com/swanson...
Thanks John!Mike
I bought it. Not sure about the thorne fractionated thing but i went to the website for the company that makes it and they list four patents claiming it’s exactly the same as the version used in the study. Thus, i bought it.
I just want to point out the latest study with n=59 subjects published in Oct 2021 was sponsored by the makers of Pectasol and did not have a placebo group (call me "Tall Allen Jr." LOL) To me, the biochemistry hypothesis seems solid and 3 x 4.8g a day is quite a large dose. The only thing I see lacking in studies to date, unless I missed them, is lack of results on blood tests to see what taking so much of this product does to your blood chemistry, liver and kidneys. A very expensive experimental supplement at about $100/month. (would be interesting to see if 2 x 4.8g worked just as well.) But what's a potentially significant life extension worth? Far more of course. But if you took this and the equivalent Sulforaphane Study dose (France, 60mg free stabilized Sulforaphane about 160mg equivalent of Glucoraphin), you're looking at about $250/month in just those two. That's cost prohibitive for a lot of people for just two of the many supplements that might be beneficial that are of course not covered by insurance.
Out of the dozens of treatments, supplements, etc, discussed on this forum, and at least 300 hours spent on Pubmed/Research Gate/Etc, Modified Citrus Pectin is the one I'm most curious about. The reason is, with most of the complimentary alternative medicines discussed here, you can find quite a wide body of research on Pubmed (not just specific to PCa) whether it be Lycopene, Curcumin, Metformin, Statins, etc, etc.
What is unique about MCP is there's relatively very little out there. And this isn't because it is too new - it looks to have been around for over 10 years! You would think that if it's so effective, you would have seen some randomized double blind placebo controlled studies without conflicts of interest. A search on Pubmed for Pectasol, Pectasol-C, Modified Citrus Pectin turns up ZILGE but I guess their search function isn't that greate. A search on Researchgate turned up only two citations both from 2019. The main one I think everyone points to is the 59 patient one, sponsored by the maker of Pectasol-C (go figure.) The fact this study was very underpowered with only 59 patients for 6 months it appears, and was sponsored by the manufacturer, raises skepticism. If this stuff is such a miracle cure (or even just significantly beneficial) where are the other studies with more patients over longer periods that aren't sponsored by the manufacturer? Is this something the famous Dr. Snuffy Myers ever recommended? No comment from Tall Allen? Very strange.
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