Here’s an update on what’s going on with me. I’ve had three Xofigo infusions, but we’ll be suspending that therapy for a bit so I can have palliative radiation on my spine. I was lucky for years that my most active lesions were in my rib cage rather than spine, but that luck has ended. My T-8 vertebra has a tumor that’s causing a lot of pain in my back and abdomen, and other vertebrae are involved with cracks and compression up to 50%. The pain going from bed to vertical is steep, but once I’m vertical, I’m functional. Pain management is with oxycodone, 5-10 mg every 3-6 hours depending upon how I feel.
The Xofigo is actually helping the rib cage. I’ve had less pain at the known lesions since the second infusion. I had appetite, nausea and GI issues from the Xofigo, but as they often say, “there’s a pill for that.” In particular, Zofran has helped a lot with nausea, and my rapid weight loss has slowed.
Tomorrow I will have my first Xgeva shot, then Thursday I will have an MRI and CT simulation for the radiation. I hope that means the radiation will start early next week. I’m expecting 5-10 sessions. We’ll get that nailed down on a Thursday.
My PSA has jumped from 50 to 218 over the past three months. I expected an increase, but I hoped it would still be under 100. My MedOnc, my husband and I had a good conversation about whether to start Xtandi. We concluded we would wait a few weeks with so much already changing at the moment. My insurance is also changing at the end of the month, and I don’t want to have the Xtandi discussion twice (“Yes, I’ve already used Zytiga. Yes, I’ve already had the ARV7 test.”).
We are going to do some DNA testing to determine whether I’m a candidate for PARP inhibitors.
My husband has joined our group, so he’ll see this, but I don’t think he’ll mind me sharing that concern is beginning to impinge on his optimism. I wish I could relieve him of that. I’m not naive, but I think this is yet another thing to attack and handle rather than impending demise. I have only one long bone lesion, and it doesn’t seem to be doing much. I also don’t have any known visceral mets.
That’s the report from here. Happy Hanakkah to those of you who observe it.