Blowing through treatments.

[Ssullivan19706]

I have gone through Chemo, casadex, Zytiga all in the last year and 1/2. All worked for a couple months then PSA elevation and growth. Now want to take biopsy and move on to targeted therapy. I am 47 diagnosed at 45. Getting a little down with having no success. Any thoughts on the genome targeted therapy. I have not seen much on that with late stage prostate cancer ?

[JamesAtlanta]

I’m afraid I don’t have any insight to offer, but know others will.

But I can offer you moral support! We are one community who stand together for each other! Please don’t get too down...there is always hope and new strategies. Let’s see what the ‘experts’ on our forum offer as advice and encouragement. 😊

And enjoy today! It is a beautiful day!🌈

James

[Ssullivan19706 in reply to JamesAtlanta]

Thank you James. Just frustrated.

[Hidden]

I'm still learning on this subject, but here's what I've read. If you have a BRCA1 or 2 mutation, the use of PARP inhibiters such Olaparib can be effective. If your cancer has significant neuroendocrine (small cell) features, platinum-based chemotherapy could be effective. You can also test for various AR mutations such as ARV-7 which would make androgen-based treatments ineffective. There are quite a few mutations which can make the cancer resistant against androgen-based treatments and there is a lot of ongoing research in this area.

I wish you the best with your treatments, please keep us posted.

[Ssullivan19706 in reply to Hidden]

Thank you Gregg

[AlanMeyer in reply to Hidden]

I don't know much about this, but there is evidence that the diabetes drug Metformin can reverse some of the resistance we develop to Zytiga and Xtandi. It apparently suppresses both AR and AR-V7 (mutation version 7 of AR).

SSullivan - I suggest that you ask your doctor about adding Metformin to your treatment.

Best of luck.

Alan