A NEW COMBINED DRUG PSMA-DOC HAS BEEN CREATED FOR THE TREATMENT OF PROSTATE CANCER!

[RusLand]

Russian scientists have managed to bind the PSMA ligand to the well-known chemotherapeutic drug Docetaxel for targeted delivery of plant venom to malignant cells with PSMA protein on its surface. The expected therapeutic efficacy is more than 80% at a dose of Docetaxel 30 mg/kg. It was also found that the docetaxel conjugate targeted at PSMA is less toxic than docetaxel itself, the reduction in molar acute toxicity compared to free docetaxel was up to 20%. It can be assumed that the selection of patients for treatment with the new drug will be identical to the selection of patients for therapy 177Lu-PSMA:

sciencedirect.com/science/a...

[RusLand]

I can also assume that with the same therapeutic efficacy as with radioligand therapy using isotopes 177Lu and 225Ac, Docetaxel therapy will cause less harmful effects on nearby healthy cells due to the absence of ionizing radiation. We will wait for the results of preclinical and clinical trials with this new drug. And may God grant us all to live up to these times! Amen!

[NickJoy in reply to RusLand]

It is great to hear from you again - and with good news. Thank you for posting and take care of yourself.

[RusLand in reply to NickJoy]

Thank you, Nikjoy! The other day I will publish the results of my treatment using the PSMA ligand and share some of my own research into increasing the intervals of administration of Zoladex 3.6 mg and the use of soy isoflavones.. And may God protect us all!

[Stoneartist in reply to RusLand]

I have been thinking along the same lines with Zoladex - it will be good to see what you come up with

[Ramp7]

Fascinating news. The beat goes on.

[E2-Guy]

Another great post by our 'comrade' and friend from Russia!

[RusLand in reply to E2-Guy]

Hello, my friend! I've seen your posts here that you're planning a trip to the States for surgery.. Have you managed to decide on the clinic for treatment and the place where you will go? I can imagine how your Natalie is going through on the eve of separation, or will you fly together? Give her my big regards! And good luck to all of us!

[E2-Guy in reply to RusLand]

Dear RusLand,

Thank you for thinking about Natalie and me! I have scheduled my AUS implant to take place in January at Loyola University Hospital in Maywood, Illinois. The trip back to Illinois' Siberia is more bothersome than the actual surgery! January is the coldest month and chances are good that I will catch a cold since I haven't been exposed to temperatures below 26°C for over four years. I will be traveling alone and returning to Natalie and Thailand will be a joyous occasion. I'm hoping that it will be the last time that I have to go back. At 79 that may very well be the case...I don't even want my ashes sent back! Our US Medicare insurance doesn't pay for anything abroad which is the only reason that I am going back. Hopefully the E2 gel that I've been using for 4½ years now is still keeping my PCa asleep? I just had my trimonthly blood drawn yesterday and will post the results in about a week. Fortunately I haven't had to see a doctor for my PCa in over five years since the E2 gel has been working wonders.

Sending our best to you and yours,

Ron & Natalie

[RusLand in reply to E2-Guy]

I'm sure it's too early to think about the ashes! My friend, this is for Natalie: สดีที่รักนาตาลี! ช่วยอธิบายให้ผมฟังหน่อยว่าปฏิบัติการแบบไหนสำหรับการฝังตัวของเอไอเอส.? ฉันประมาณเข้าใจว่านี้เป็นเพราะปัสสาวะเล็ดแต่ฉันไม่เข้าใจสิ่งที่ต้องทำในกรณีนี้.?! นประเทศไทยมีราคาแพงมากและในอเมริการอนสามารถทำมันสำหรับทุนประกัน. ฉันต้องการที่จะเข้าใจสิ่งที่ชนิดของการดำเนินงานมันเป็นและได้รับราคาสำหรับค่าใช้จ่า. ที่ที่ฉันมีเพื่อน-อวัยวะ. ฉันเพียงต้องการที่จะเข้าใจครั้งแรกของทั้งหมดเท่าใดเงินที่เรากำลังพูดถึง! ขอบคุณ! คุณสามารถหาฉันที่:[e-mail]

[dhccpa in reply to E2-Guy]

Best of luck on your PSA results!

[E2-Guy in reply to dhccpa]

Thank you mate!

[Boywonder56]

🇮🇪🇺🇦...

[tango65]

Thanks for posting.

The article you posted refers to preclinical studies in mice. There is not information in clinical studies in humans. I hope things could be worked out and they could do clinical trials.

There are clinical studies with a PSMA-Docetaxel ligand called Bind-014

ncbi.nlm.nih.gov/pmc/articl...

There is other PSMA guided chemo , ARX517in phase I clinical trials

cancer.gov/publications/dic...

ambrx.com/pipeline/

clinicaltrials.gov/ct2/resu...

[RusLand in reply to tango65]

Hello, tango65! As far as I know, mice and other animals were not used in this work! The effectiveness at the cellular level was demonstrated using special sensors developed at the Biophysics Laboratory of NUST MISIS Moscow. BIND-014, which you are talking about, does not contain a vector molecule of the PSMA antibody in its composition. BIND-014 is an artificially created nanoparticle loaded with Docetaxel and targeted at the PSMA protein on the cell surface. And the second drug PSMA ADC ARX517, which is referred to in your links, really contains the PSMA ligand in its composition, and then there is a complex compound of humanized immunoglobulin G1 and two amberstatin toxins (AS269), which, I think, few people have heard of here. In my own publication. I talked about a completely new combination of PSMA-DOC, consisting of two well-known components: the PSMA ligand and Docetaxel, which have already been approved separately for use by many regulatory authorities, including the FDA. Of course, clinical trials on patients are still ahead, but something tells me that they will be held quickly and with success. My opinion!

[tango65]

I thought you were interested on targeted chemotherapy which is something I am very interested. I was not trying to compare different tecniques. Just mentioning the ones I was aware of.

I read the full article of the summary you posted and they did dothe preclinical studies in mice.

[RusLand in reply to tango65]

Of course, I, as well as many here, am interested in everything that can kill cancer, and especially when it is achieved by targeted delivery of the killer to the victim ..)) Thank you so much for your links, I have already filled up my archive with them! I have heard about the use of mice in this work from you for the first time and I will definitely pay attention to this in the future! Best wishes of success to all of us on our thorny path!

[Spyder54]

like Leutitium 177/J591, but with chemo vs liquid radiation. One of these will be more effective and become the new standard.

I would bet some react better to Docetaxel and others Leutitium. . New Fronteir. Hopefully another 10 years for us!!! Mike

[johnscats]

Thanks great info

[TJGuy]

Thanks for the info, I'll look back in my notes, see if I can find what I believe was another unique identifier of PC besides PSMA which of course isn't in all of most people's PC, and that's the problem.

One of these was the PH level of PC cancer which might be a unique identifier, but that's not what I'm trying to remember.