I mentioned on earlier posts that when my PSA reaches 2.0 my doctor at MD Anderson wants me to either start Zytiga with prednisone or join the Dynamo clinical trial (NCT02703623).
My PSA jumped 0.5 points this month, to 1.8. It has doubled in 9-months. So I want to begin determining which treatment I want to do next.
As a reminder, diagnosed in 2015, PSA 227, bone met in T8 vertebra, Gleason 4+4=8, ADT since diagnosis, 6-rounds of docetaxyl, radiation of T8. My overall health is good, still able to work full time. I do have muscle weakness, but still exercise a lot, manageable fatigue, and a little memory loss at times.
Is anyone on this site in the Dynamo trial? If so, what are your thoughts? My local oncologist read the trial and seemed a bit alarmed with the potential side effects and toxicity of the drugs, depending upon what group I might be assigned. He seemed to lean toward just starting Zytiga and prednisone.
And asking a broader question, what considerations should I have if I elect to enter into any clinical trial?
Thanks for any insight you may have.