Amg160 did not work

[Birdfeed]

I posted a few days ago about my husband’s side effects of amg 160. He started having upper spine and hip pain. They did a mri and his cancer has spread. They put him in the hospital gave him steroids and are doing radiation to the tumors in his upper spine, lower spine, and hips.

When they did the Psma scan they said he has Lots of Psma in his cancer. If anyone knows why it didn’t work and what would be the next step?

He was diagnosed in January 2020 with aggressive prostate cancer and is in all his bones. He is being treated at Sloan Kettering. His treatment so far has been, Lupron every 3 months,Zytiga only worked 1 year then 6 treatments of chemo, didn’t work, then Amg 160.

His brother died a year ago after 5 years of fighting prostate cancer. Nothing was found with genetic testing.

Sorry for the long post but getting desperate.

[Tall_Allen]

You may want to read this to understand why PSMA-directed therapies may not work even when there is PSMA avidity:

prostatecancer.news/2019/12...

Is he a candidate for the Th-227-PSMA trial at MSKCC?

prostatecancer.news/2018/10...

[Birdfeed in reply to Tall_Allen]

I’ll look into that, thanks.

[tango65]

AMG 160 use PSMA to identifies cancer cells but the killing of the cells is done by the immune system.

"AMG 160 is a targeted half-life extended, bispecific T-cell engager (BiTE®) immune therapy that engages a patient’s own T cells to kill prostate cancer cells via binding of CD3 on T cells and PSMA on cancer cells"

urotoday.com/conference-hig...

It is different than Lu 177 PSMA, Ac 225 PSMA or Thorium 227 PSMA. With these treatments the PSMA targeted cells are killed by the radiation of the metal attached to the ligand identifying the PSMA expressing cells.

[Danielgreer]

It’s remarkable how two different patients with similar situations get such different treatments. I also am metastatic to bones only and ADT plus Darolutamide only gave me about 14 months until I became CR. After that I had Provenge and then Xofigo. My MO is now recommending either the Cabometyx with Tecentriq clinical trial or perhaps wait for 177 Lu to be approved. Did your MO ever talk about Provenge or Xofigo? Xofigo is used for cancer in the bones only.

[Birdfeed in reply to Danielgreer]

We go to see him on Thursday hopefully something will help. He is very weak and in pain.

[Danielgreer in reply to Birdfeed]

I wish you the best

[Birdfeed in reply to Danielgreer]

Thanks.