Brca1 and metastatic prostate cancer

[danyelpolo]

Hello , I came across this web page while searching for options for my dad . 73 yr old with metastatic prostate cancer . He has brca1 gene . Zytiga and xtandi both stopped responding , he has been on olaparib for 6 months . Recent scan showed progression AND rise is psa. What should be next step . Local dr says chemo , but was hoping for clinical trailsTHANKS FOR ANY ADVICE

[naples2021]

Hello and welcome to the group. Can you tell us a little bit more about your dad diagnosis such as initial PSA, if he has bone metastasis , how long was he in ADT ?

[danyelpolo in reply to naples2021]

Hey - his psa right now is a 7 - it has been has high has 49 - he does have bone metastasis

[2dee]

I've been on Lymparza for about 4mos now. I "feel" as good as I've felt in years.Extreme fatigue. My PSA has risen from around 16 to now 41.5. CT scan clear, lymph nodes smaller. We have no idea why it is increasing.

Getting another body scan soon. I have mets throughout my skeleton. Less now after ADT treatments.

Hope we find where it's treatable.

2Dee

[danyelpolo in reply to 2dee]

Wish you the best - his has progressed with Lympraza

[Tall_Allen]

Many clinical trials require chemo first.

[noahware]

Novartis is currently recruiting for Lu-177 trials in several states (and in several foreign countries): 'clinicaltrials.gov/ct2/show...

At first glance your dad might be eligible, as it seems open to men who have NOT had prior chemo but are metastatic and have progressed after failing ADT and at least one other agent. There is a mention of BRCA as a possible exclusion, but perhaps because your dad is not responding to olaparib he could be eligible? Worth checking out, anyway. Best of luck!

[danyelpolo in reply to noahware]

Thank you

[j-o-h-n]

Greetings Daniel.....

Would you please be kind enough to tell us his bio. Age? Location? When diagnosed? Treatment(s)? Treatment center(s)? Scores Psa/Gleason? Medications? Doctor's name(s)?

All info is voluntary, but it helps us help him and helps us too. When you respond, copy and paste it in his home page for his use and for other members’ reference.

THANK YOU AND KEEP POSTING!!! (You've come to the right place)

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 02/27/2022 7:20 PM EST

[danyelpolo in reply to j-o-h-n]

73 years oldDiagnosed March 2020

Mississippi

Also see DR Pilie at MD Anderson

Metastatic prostate cancer

Psa 15 March 2020

Brca 1 positive

Gleason 9

May 202O leuprolide injection

May 2020 psa 25

June 2020 Abiraterone with prednisone

August psa .7

September 2020 enzalutamide changed from abirateone due to high levels of lfts

He has been on zytiga and xtandi with rising psa so started olaparib in august 2021

Psa 7 February 28

Progression of bone metastic

[j-o-h-n]

Thank you sir for your prompt and detailed reply. This is a great site for information regarding Pca. Keep posting...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 02/27/2022 9:03 PM EST

[bubbles48]

I had about the same situation. I have BRCA 1 also. My next step after olaparib was chemo. I wish you dad so much success.

[danyelpolo in reply to bubbles48]

good morning, so are you taking chemo now ? did you not quaifly for any clinical trails ?

[bubbles48]

I have had ten rounds of docetaxel (taxotere). It has been rough on the last few. I live so far from Duke Cancer Center where I am under the care of Dr. Daniel George, oncologist that they do not usually consider me. Also I have a background of Crohns disease of the large and small intestines and Ankylosing Spondylitis (a form of arthritis of the spine). These things usually eliminate me from any clinical trials and even from treatments. Right now I am at a crossroads and will see the doctor this week. More chemo is one option for me. I have very few options left. Do every option you can.

[danyelpolo in reply to bubbles48]

thank you ! hope you get more options as well

[Kcski]

Hi,

My Dad is 74 and also has advanced prostate cancer.

His initial response was Docetaxel, chemo, for six rounds. It killed a ton of his cancer!

The first rounds of chemo treatment were not too bad for him. The last two bothered him more, but he toughed it out. He also worked out the whole time and ate as much non processed food as possible, both of which helped.

His psa number started at like 8,000 and has been reduced to .3 and moved up slightly after two years to .6.

I would strongly recommend the Taxotere chemo therapy!

Sincerely,

Karyn

[danyelpolo in reply to Kcski]

Wow thanks for the info , did he have bone met. ?

[Kcski]

No bone mets. He is very active and that helps with bone mets, imho. He had an almost blockage by the bladder and lymph node involvement in the groin, though. The Docetaxel shrunk the heck out of it! On a side note, he does not have BRAca gene. Not sure if that matters, though.