Hi everyone, I am a 56 year old male with bone mets in hip and femur. (Gleason - 8, 11 of 12 cores cancerous). I went on Casodex two weeks prior to my 3 month Lupron injection almost three months ago. After just over a month, my PSA level dropped from 8.8 to 1.0, and my testosterone level dropped to less than 3 ng. Very fortunately, I became eligible for a clinical trial; therefore, had to have complete blood work completed this week (one week before my next 3 month Lupron injection). I just received the test results and, since my last blood test in early May, my PSA dropped to 0.125 (from 1.0), but my Testosterone rose from less than 3ng to 19ng. I am wondering if any of you have any experience with this. Of course, my paranoia is that I am becoming ADT resistant after only 3 months since the testosterone level is rising....and that the PSA level is sure to follow. On the other hand, I am hoping that maybe the fluctuation of 16 or so ng may be normal and I am still within a safe range.....or, maybe since it is time for my next Lupron injection next week, the effects of the 3 month Lupron injection are starting to wear off, and this is just normal behavior for the testosterone level. I just wanted to mention again that I do take 50 mg of Casodex daily in addition to the 3 month Lupron injections. I haven't seen this question addressed, cant find it with searches; therefore, would so much appreciate it if any of you with experience in this category would be able to provide any feedback. Thank you all so very much again!