After 13 cycles of docetaxel and 4 of cabazitaxel, both have stopped working, at least alone. CT and bone scans yesterday both showed modest progression in mets in bone, lymph and liver. The shocker came today when I learned the PSA jumped from 1952 to 3580. I have no pain (knock wood), and have had no problems with nausea or fatigue during chemo. I have oncologists in Seattle and at Duke who will confer on treatment options while we wash my system with a short chemo break. If others who have faced this situation would share your experiences and treatments, I would appreciate the input. I have been through both Zytiga and Xtandi and continue to receive Lupron injections. I know my Seattle doc is participating in a trial using docetaxel, Carboplatin and sirolimus. The doctor ar Duke mentioned trying oxaliplatin with Gezmar.