Experiences with

Oxaliplatin

Stage 3 colon cancer Resection 1 1/2 yr ago followed by 12 cycles of Folfox over 6 months Peripheral Neuropathy started in the first couple of cycles and following cycle 7 had to stop oxaliplatin component which causes peripheral neuropathy in some patients It has been 1 year since my last cycle and

Then started chemo xeloda and oxaliplatin. Finished maybe feb 5ish. While doing this Chemo I was not good at all like 3.5 months in. Like right around Xmas or Jan. It was like I was having too much of it.

I have been told to strongly consider Chemotherapy both Intravenous and oral: oxaliplatin and cepecitabine. I am looking for anyone who has had this chemotherapy and any feedback (I understand everyone reacts differently) as I am scared and don’t know anyone who has.

The chemo recommended is more specifically- gemcitabine/oxaliplatin (GemOx) based on the report of a phase II trial by JL Lee et al (Br J Cancer. 2014 May 13;110(10):2472-8). PSA response rate was 55% (95% CI, 38-72) and radiologic response rate was 82% (9 out of 11).

She started on oxaliplatin which was administered over a period of 6 months. Oxaliplatin has left her with severe neuropathy resulting in the loss of mobility her hands and feet. She had a scan 3 months after finishing chemo only to be told the cancer had returned in the same places as before.

Doctors are divided about advising chemotherapy and I must make a decision, as I've done first cycle on 19 March (Oxaliplatin and Capecitabin) and next one was postponed until 29 April, so I can gather more information to make a decision.

Also Oxaliplatin can maybe cause more nerve damage in hands and feet than Taxol? As someone who does art work I do not want to lose sensation in my hands so I'm feeling pretty bleak at mo. Sorry to moan. X

He has been having Rituximab with Gemcitabine and Oxaliplatin. However yesterday his Consultant said his platelets are too low (50) to have the 6th and final planned dose.

Tooth Disease link http://cmt.org.uk/wp-content/uploads/2015/04/NeuroMeds.pdf Proposed list of medications of concern to patients with CMT Definite high risk (including asymptomatic CMT) Vinca alkaloids (vincristine) Moderate to significant risk Amiodarone Bortezomib (velcade) Cisplatin, carboplatin, oxaliplatin

I'm due to start a new regime of oxaliplatin and capecitabine in a couple of weeks. Has anybody on here received this type of chemotherapy and could you give me an insight into what I can expect side effect wise? Thank you in advance Katie

January 2015 Received 3 months chemo of 5FU and Oxaliplatin - suffering from Neuropathy in the hands and feet still, then 35 days of targeted radiotherapy to the Pelvic wall. Took 6 months off treatment and recommenced in January 2016 with 3 months Avastin & Irinotecan infusion (nasty!)

The doctor ar Duke mentioned trying oxaliplatin with Gezmar.

As weekly Taxol caused tinnitus, they had a hard time trying to find out something that wouldn't worsen the symptoms, so GEMOX it will be: Gemcitabine and oxaliplatin, every two weeks (around 6 hours). It will apparently come with nausea, fatigue and sensitivity to cold.

I am currently undergoing Chemotherapy using Oxaliplatin, Fluorourail with premeds of Benedryl, Decadan and Pepcid to help control nausea. Some days my chest hurts in the esophogus and upper stomach area. i have a very bad soar throat. i feel nausea.

She stopped the chemo, but called me 3 days letter and said we would try Taxol and Oxaliplatin, still a derivative of Platinum.. That will start today..in about an hr.. Due to the pain in the feet and knees I started taking Ibuprofen 600 mlgr twice a day.

Carbo ,then taxol,12 out of 18,then carbo again only 2 as took anaphylactic reaction 3/52 ago .due to start oxaliplatin ( eloxatin) today .before it started the dr decided no due to another medical condition it wasn't worth the risk .has been told caelx and cisplatin are not an option as too severe.does

Development of rituximab (Rituxan)-containing intensive chemotherapy regimens and chemo-immunotherapy regimens (eg, R-HyperCVAD [rituximab plus hyperfractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone] or OFAR [oxaliplatin (Eloxatin), fludarabine, and ara-C]) have improved response

The thing I find strange is that as soon as I had the oxaliplatin infusion 10 days ago the bloating went away immediately and I was much more comfortable. My stomach looked normal. This lasted a week then it began to swell again.

I'm in the middle of 6 doses of oxaliplatin and capecitabine for a recoccurance of mucinous ovca. I'm suffering badly each time being sick, nauseous for a week and retching.