Ex told today that because his significant tumors are both anterior and posterior vertebrae fractures, surgery is not possible to alleviate pain. Given stronger pain meds and will get direct and xofigo radiation soon. What should he expect? PSA is skyrocketing and because PSA and pain only increased in the 5 months of Xtandi, his chance of positive response to zytiga is only about 20%, according to research studies. Any advice on what to do now? Thank you for everyone's thoughtful responses and knowledge all things prostate cancer.