Green tea and quercetin may sensitize PCa to docetaxel

New mouse study below.

"GT {green tea} + Q {quercetin} or LD Doc {low dose Docetaxel} slightly inhibited tumor growth compared to control. However, the combination of GT and Q with LD Doc significantly enhanced the potency of Doc 2-fold and reduced tumor growth by 62 % compared to LD Doc in 7-weeks intervention."

Coincidentally, another polyphenol + Docetaxel study appeared in PubMed today.  Not a PCa study, but chrysin improved Docetaxel results.  Also, there were reduced side effects.  Chrysin prevented edema - no swelling in those little mouse ankles at all.  

Some say that chrysin is useless - has little bioavailability.  It is a natural aromatase inhibitor, & the bodybuilder sites are all interested in that, since inhibiting the conversion of testosterone to estradiol might increase T levels.

The problem with chrysin is that so much of it is metabolized by the liver in the 'first pass'.  Piperine [Bioperine] inhibits the liver enzyme that clears it:

swansonvitamins.com/swanson...

Before I could get a prescription for Arimidex, I used chrysin + piperine & it kept my estradiol at about 20 pg/mL, so I know that chrysin can be bioavailable.

Bioperine is cheap.  It comes from black pepper, but black pepper itself is ineffective.  One must be wary of combining it with oral drugs that will be subjected to first pass metabolism.

  

-Patrick

ncbi.nlm.nih.gov/pubmed/271...

J Exp Clin Cancer Res. 2016 May 6;35(1):73. doi: 10.1186/s13046-016-0351-x.

Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy.

Wang P1,2, Henning SM3, Magyar CE4, Elshimali Y5, Heber D3, Vadgama JV5,6.

Author information

Abstract

BACKGROUND:

Chemotherapy with docetaxel (Doc) remains the standard treatment for metastatic and castration-resistance prostate cancer (CRPC). However, the clinical success of Doc is limited by its chemoresistance and side effects. This study investigated whether natural products green tea (GT) and quercetin (Q) enhance the therapeutic efficacy of Doc in CRPC in mouse models.

METHODS:

Male severe combined immunodeficiency (SCID) mice (n = 10 per group) were inoculated with androgen-independent prostate cancer PC-3 cells subcutaneously. When tumors were established the intervention started. Mice were administered with GT + Q, Doc 5 mg/kg (LD), GT + Q + LD Doc, Doc 10 mg/kg (HD) or control. The concentration of GT polyphenols in brewed tea administered as drinking water was 0.07 % and Q was supplemented in diet at 0.4 %. Doc was intravenously injected weekly for 4 weeks, GT and Q given throughout the study.

RESULTS:

GT + Q or LD Doc slightly inhibited tumor growth compared to control. However, the combination of GT and Q with LD Doc significantly enhanced the potency of Doc 2-fold and reduced tumor growth by 62 % compared to LD Doc in 7-weeks intervention. A decrease of Ki67 and increase of cleaved caspase 7 were observed in tumors by the mixture, along with lowered blood concentrations of growth factors like VEGF and EGF. The mixture significantly elevated the levels of tumor suppressor mir15a and mir330 in tumor tissues. An increased risk of liver toxicity was only observed with HD Doc treatment.

CONCLUSIONS:

These results provide a promising regimen to enhance the therapeutic effect of Doc in a less toxic manner.

KEYWORDS:

Combination; Docetaxel; Green tea polyphenol; Prostate cancer; Quercetin

PMID: 27151407 [PubMed - in process]

3 Replies

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  • Patrick ,

           Another great abstract, I will be sure to have plenty of Green tea and Quercetin  on hand when it is time for me to do Taxotere. It may be that time for me now, I will know next weds, if so I am going to continue with my plans to Go to Alaska for the spring solctice and worry about it when I return.

    Dan

  • Just remember this is a mouse study and many animal studies do not translate into people.

    Joel

  • One must be wary of combining it with oral drugs that will be subjected to first pass metabolism; suah as Casodex. A very good insigth you brought to the community.

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