Waning antibody levels over time

[vivdunstan]

The Guardian this afternoon ran an article about waning antibody levels after the vaccine, and why boosters are so important.

theguardian.com/world/2021/...

I managed to find what I think is the linked academic paper about it in The Lancet.

thelancet.com/journals/lanc...

Interestingly this gives some hard figures for antibody levels for a large population, and allows those of us with antibody readings to put our results into some context.

Pfizer is more effective than AZ at generating antibodies. Antibodies wane over time though.

My healthy husband's result of 829 seems about average (good!) for AZ (average 864). Whereas immunosuppressed me had a result of just 16.4 ...

[EGPAGuy]

Interesting stuff Viv . Will need some time to disseminate. I got a count of 380 from Pfizer against my healthy wife's count in excess of 2500..albeit I am currently just managing on pred whilst waiting on next regime to start. Will be giving blood for the Addenbrookes/Camb uni research next week but do we know the source of data..apologies if its in the article only gave it a quick glance.

[vivdunstan Volunteer in reply to EGPAGuy]

From the Lancet paper: “a cross-sectional analysis of fully vaccinated adults (aged ≥18 years) who submitted capillary blood samples for Virus Watch, a longitudinal community cohort study in England and Wales”. 605 patient samples. The paper and appendices break the patient group down by category more. Eg it includes some immunosuppressed, but the paper doesn’t give their results separately from other CEV.

[nanaC]

Thank you for this information. I was originally over the moon to have a count of 150, especially as it was said that plasma to help Covid patients was taken from anyone with a count above 62. This puts things in a bit more perspective.

[Mooka]

Thank you that’s really interesting. I know I have antibodies but frustratingly don’t know how many. It certainly seems to vary considerably. I think the worry for those of us that have had rituximab is the lack of B cells.