Interesting research on antibodies

Was very interested by this research into how autoimmune disorders (AD) arise. My mother has rheumatoid arthritis and I have psoriasis and LS. This falls in line with the article I'm pasting from, 'When the immune system goes on the attack'.

"Hal Scofield, Professor of Medicine at the University of Oklahoma's Health Sciences Center, reviewed the blood samples of six million US military personnel, taken routinely on induction and then every two years after that. He traced the existence and persistence of various auto-antibodies over a decade, and correlated them to individuals who ultimately received lupus diagnoses. “Antinuclear antibodies and anti-Ro appeared as early as 10 years before first onset of [SLE] disease,” Scofield said. “Except in diabetes, it had not been shown before that the respective auto-antibodies preceded the emergence of disease.” He also cited other studies showing that the existence of other antibodies can predict who will develop RA, primary biliary cirrhosis, autoimmune thyroid disease and type 1 diabetes, a median of 4–5 years before disease onset. “If you can identify a patient before he becomes ill, it may be possible to use an immunomodulatory strategy to prevent him from becoming ill,” Scofield said."

This bit is at the end:

"But perhaps the best hope for long-term remissions in ADs is coming from autologous haematopoietic stem-cell transplants (HSCTs) that 'reset' the whole immune system by replacing it with fresh cells. Richard Burt got this idea 14 years ago when working with cancer patients. “I noticed that patients who had had bone marrow transplants had to be re-immunised for infectious diseases because they'd lost their immune memory,” he said. So began a plan to regenerate a naive immune system from uncommitted, newly developing stem cells.

Kinds Regards Snezana

3 Replies

  • Thanks for this Snezana, very interesting.

    Is this the article ?

    If so it's quite an old article and so may have been superseded, but regardless it seems very relevant to vasculitis too.

    The bit about autologous haematopoietic stem-cell transplants is also interesting. We know a member who is currently just starting on this treatment.

  • Dear Shezian,

    I have read, your 'post', a couple of times-it is very interesting, thank you. Can you provide a 'link', to the research-or even provide an 'Email address'? As I have not personally heard of this research specifically- though, as is usually the case, I am aware of 'on-going research'- in general terms.

    Do look through some of our posts that, I'm sure, you will also find interesting.

    Once again, thank you Shezian, we look forward to hearing from you.

    Kind regards AndrewT

  • Shezian

    If you have the reference link, I would be most grateful... the one I saw was dated on 2008.

    I am in need of a replacement immune system which has been trying to murder me and blind me since a few years ago.. :(

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