I'm new to this group. Gleason 10, diagnosed 2007, surgery 2007, failed 2010, radiation 2010, failed 2011. PSA gently rising on Muscadine clinical trial until positive biopsy on swelling in bladder wall Dec 2014.
Began Hopkins Clinical Trial Jan 2015 using 3-month Eligard & daily 50mg Casodex. PSA undetectable since then & the bladder wall swelling has "resolved." Side effects, sure, but as we like to say "I can live with them." Passed the 2-year mark on ADT a few months ago, still working full-time managing an international NGO. My Onc prescribed Venlafaxine when hot flashes got bad; not bad at all now, seems to work!