Still desperately trying to sort myself out and am feeling really angry today following the latest 'report' from an endocrinologist who, despite my ongoing symptoms of ill health, claims she cannot help me and doesn't want to see me for another year!
Despite her brief as an endocrinologist to evaluate my thyroid or possible Cushings and look into the adrenal adenoma I have she insists on looking at other things which is driving me mad.
I have all the usual issues that so many of you on here have with this ongoing problem.
I believe that my situation was made a lot worse by the lack of diagnosis of a serious lactose intolerance which left me housebound for almost 20 years, doctors as ever preferred the term 'irritable bowel' and did nothing.
I have had problems with type 2 diabetes, blood pressure, high cholesterol, triglycerides etc for years, I will not take statins etc which is a bone of contention with the endocrinologist. My esearch tells me this will make things worse and is not the best course of action for people with thyroid disease.
Having discovered my lactose intolerance I have, at a stroke, eliminated all the shocking bowel disorders I had to live with for so long.
Back in the 90's I believe I should have been put on thyroxine but instead was put on HRT, this has been a disaster and I now think that this threw my hormones into imbalance. Something I am trying to address but with no help or support it is very, very difficult.
Since way back in the 90's I have had very low sex hormones, Testosterone undetectable, Androstenedione and DHEAS undetectable, SHBG always very low. I have asked and asked the doctors to look into this without any success whatsoever. Now I have been looking into it some more and have discovered that low SHBG is far more serious than the doctors seem to accept and could provide an explanation for my problems.
•Low SHBG is a Key Marker of Cardiovascular Disease, SHBG levels have an important relationship with nearly every biomarker of cardiovascular disease, from C-reactive protein (CRP) to arterial calcification. Low SHBG is also associated with elevated triglycerides and low-density lipoprotein (LDL).
•Low SHBG is associated in the cluster of conditions known as the metabolic syndrome, which encompasses obesity, insulin resistance, lipid abnormalities, and chronic high blood pressure.
•SHBG production is strongly influenced by sex hormones, increasing in high oestrogen states and falling in high androgen states. Production is also affected by age, corticosteroid status, thyroid status and other factors.
•Concentrations are commonly low in polycystic ovarian syndrome, contributing to the excess androgen effects in this condition. Low concentrations of SHBG in obesity, hypothyroidism and acromegaly may influence total testosterone concentrations indicating the need for an assessment of free testosterone concentration.
What I cannot find out as yet is how to raise SHBG levels other than take green tea and soya! Anyone know anything more about this aspect?
I have a lousy endocrinologist but a great GP who has agreed to checking the status of my sex hormones, intrinsic factor, homocisteine and thyroid anti-bodies but past experience shows me that I'm not over the hurdle yet as the lab can sometimes refuse these tests. I can't afford to go private yet so am hoping we get them through.
I am quite horrified by what I am reading about SHBG and I would love to know if anyone else has knowledge of this aspect or could point me in the direction of more research/info