Thyroid/ peri menopausal link.

[Angelic69]

After reading the attached article i can not help thinking that due to the feedback from lowering sex hormones this would give us a high TSH reading but would reflect low oestrogen, progesterone,testosterone which is creating the higher-ed TSH. but if i understand correctly does not mean we have thyroid disease. could someone explain why they prescribe replacement thyroid hormones and not the sex hormones.

[Angelic69]

Sorry i forgot to add link

hormone-zone.com/blog/5950-2/

Estradiol lowers TSH: When women first enter perimenopause and eventually menopause, which is accompanied by lowered estrogen, it is very common to see hypothyroidism (low thyroid) develop, which will usually be marked by an elevation in TSH (Thyroid Stimulating Hormone). Restoring the estrogen levels will help to lower TSH, partially relieving the low thyroid state. But there is more to it…

[Baobabs in reply to Angelic69]

But surely this is not necessarily the explanation for autoimmune thyroid disease, very interesting though it is?

[Angelic69 in reply to Baobabs]

Do they test for antibodies on the same blood draw or after a diagnosis of thyroid disease is established, im not sure of their protocol, any ideas.

[Baobabs in reply to Angelic69]

Mine happened at the same time, Thytoid stim hormone, T3, T4. Antibodies and ultrasound.

[Angelic69 in reply to Baobabs]

Not sure for mine as GP who requested test did not give me the results and despite the locum who gave me the results stating it was autoimmune my normal GP said it was not autoimmune and asked who had told me that it was was incorrect. S on that i assume she had not ordered the antibodies test at same blood draw.

[greygoose in reply to Angelic69]

I don't think they do in the UK, because doctors are so ignorant and money-pinching. But, here in France, I had the full lot done first test, and that is the way it should be done.

[Baobabs in reply to greygoose]

Yes agreed, I have private med cover in Saudi.

[Baobabs in reply to greygoose]

Greygoose there is no mention of antibodies, just hormone reactions/interactions and the lack of them. Surely the existence of antibodies tells a very different story. What are your thoughts bearing in mind some 80% of thyroid problems are autoimmune? Think I’m right?

[greygoose in reply to Baobabs]

Well, yes, you're right. And if you have an autoimmune thyroid problem, that would affect your other hormones. This ties in with the quote I just left for Angelica69 in another post:

healthunlocked.com/thyroidu...

Obviously, if you have Hashi's or Grave's, it will affect all your other hormones. But, that's not what Angelica's article is talking about. It's talking about how hormones affect each other if they're out of kilter, whatever the cause. It's not supposed to tell the whole story. That would need several articles.

[Baobabs in reply to greygoose]

Mmmmmm think I get your drift. Thanks.

[greygoose in reply to Baobabs]

[Angelic69 in reply to greygoose]

Greygoose could you help me understand this passage, does in mean yes the fight or flight would or would not create cytokines. It hard to digest. Hope you can help.

Just reading info on autoimmune and endocrine relationships which lead me to this not sure if it means an increase in these proteins equals autoimmune issues.

Generally, it is assumed that stress-related HPA and sympathetic nervous system activity inhibits the functions of inflammatory cells, in particular cytokines (such as IL-6 and TNF-α)10. Whether this mechanism is also activated during acute stress has remained elusive in previous research.

[Angelic69 in reply to Angelic69]

Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers.

Does this mean that consistent stress events causes autoimmune disease by prohibition of above mentioned cytokines. Im i on the right track/

[greygoose in reply to Angelic69]

I'm afraid I have no idea. That extract doesn't mention autoimmune disease.

[Angelic69 in reply to greygoose]

Just thought that if we are in a constant stressful state the fact that only stress hormones would be in production then that would cause the same effects as autoimmune disease, insulin is effected, oestrogen, progesterone, testosterone all other hormones would be compromised which would result in lots of the autoimmune diseases. You can not have a tea party with one teabag.

[greygoose in reply to Angelic69]

But it's not only stress hormone that are in production. Glands carry on making hormones the best they can, stress or no stress. And it's not compromised hormones that cause autoimmune diseases. There are all sorts of causes. Leaky gut being one of them. And excess iodine can trigger Hashi's.

[Angelic69 in reply to greygoose]

ncbi.nlm.nih.gov/pmc/articl...

[greygoose in reply to Angelic69]

It says 'endocrine disorders', not 'autoimmune diseases'. And whilst Grave's and Hashi's are autoimmune diseases (although it doesn't mention Hashi's) not all autoimmune disease are endocrine disorders, and vice versa. I think you're reading things into that article that aren't there.

[Angelic69 in reply to greygoose]

By looking at the list they seem to be either directly associated with the endocrine system or due to narcosis which could be due to the suppression of the cytokines during stress overload.

[Kalicocat in reply to Angelic69]

This is what they are looking into now - bacteria as a cause for autoimmunity:

sciencedaily.com/releases/2...

[greygoose in reply to Angelic69]

I think it's saying they don't really know.

[Baobabs in reply to greygoose]

Love it!

[Angelic69 in reply to greygoose]

If the body did not make these cytokines to repair itself or heal itself and they originate in there product from a feedback from the endocrine system resulting in autoimmune diseases then i just assumed it would be the cause.

[greygoose in reply to Angelic69]

I don't know. I really couldn't say. It's a bit deep for me on a Sunday evening.

[Baobabs in reply to greygoose]

Greygoose, Sunday evening or not, you’ve done damn well to respond to this issue. I got lost off a long time back!

[greygoose in reply to Baobabs]