anyone else done the quadruple antibiotic thera... - Thyroid UK

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anyone else done the quadruple antibiotic therapy for h pylori and survived?

Crankyoldbag profile image
22 Replies

i’ve tried all the natural remedies and am still testing positive for this plus i also have SIBO.

Tried matula tea (1 month perhaps not for long enough) mastic gum, Toxaprevent.

The quadruple therapy is made up of bismuth, tetracyline, metronidazole and omeprazole for 10 days. Absolutely dreading it but feel i have no choice as gut in such bad shape.

thanks very much for your feedback

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22 Replies
Smartypants1 profile image
Smartypants1

I can’t help you with the effects of the four together but have been on metronidazole for a parasite. I was expecting it to be awful but I had no side effects at all, other than a bit of dizziness. Sorry I couldn’t be more help

Agapanthus1 profile image
Agapanthus1

yes, I took these after a gastroscopy picked up h pylori. I only had the 2 antibiotics tetracycline & metronidazole though as the other drugs you mention are a PPI & bismuth, presumably given to lower/ deal with acid. I had been prescribed a PPI prior to the gastroscopy only to then find that they were the opposite of what I needed as my issue was low acid not high related to the pernicious anaemia & Hashimoto’s I was later diagnosed with. I can’t remember any serious side effects from the combo of antibiotics, other than slightly loose stools. I took a good dose of probiotics before & after the treatment. Good luck!

PS. PPIs also block the absorption of b12 (& I would guess some other nutrients) so not a good idea generally & the worst possible thing to give someone with very low b12/pernicious anaemia!

Crankyoldbag profile image
Crankyoldbag in reply toAgapanthus1

Hi, i think the bismuth is to help with eradication and the ppi to protect your stomach. Did you redo an endoscopy or breath test after the treatment and test negative for h.pylori?

Did you feel better after the treatment was finished? Digest better?

Agapanthus1 profile image
Agapanthus1 in reply toCrankyoldbag

Ha! No of course there was no repeat testing or endoscopy!! It was the NHS. The whole thing was an absolute sh**show tbh, & I was more concerned that I had pernicious anaemia & Hashimoto’s & was pushing for testing/ treatment regarding that. I was then started on the protocol for PA of intensive b12 injections & not long after (inadequate amounts of) T4. I can’t really say that I felt better because there were these other issues going on but my gastro symptoms were never that bad, more like indigestion which I don’t have now.

This was 2016 so the protocol may have changed for h pylori but I’ve just checked & the NICE guidance stipulates the 2 abx & a PPI (which I would definitely avoid long term). No mention of bismuth. Acid reflux type symptoms are just as likely to be low acid rather than high with a thyroid condition , so I would look into that. With adequate thyroid replacement, low acid is often helped. I follow the Zoe protocol for gut health & never have any tummy/ gastro issues. I also read somewhere that chamomile tea (I think?)is good for h pylori, so Google that maybe to check. All the best! ☺️

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Crankyoldbag profile image
Crankyoldbag in reply toAgapanthus1

Thanks very much. I’ve never had acid reflux just very bad digestion. Undigested food particles in stools. Inability to eat large meals etc green stools. I had a huge amount of stress in last 6 months which i think increased inflammation with existing h.pylori.

I’m in France and the quadruple protocol is bismuth, tetracycline, metronidazole and omeprazole. So in fact 2 abx plus bismuth which helps eradication.

Its quite easy to get either a breath test or stool antigen for h pylori from one’s GP. I’ve found the breath test to be more accurate in terms of how much information it gives.

Hypopotamus profile image
Hypopotamus

H Pylori is naturally found in the stomach, and is not a bad things until we get too much of it. I read somewhere that it is present for a reason, and we should not get rid of it completely.

As always, and based on personal experience, I strongly recommend trying a probiotic , with water kefir being the one that I find easiest to make and take. decdun.me.uk/Kefir/Water_ke...

Optimist1234 profile image
Optimist1234

I would highly recommend drinking freshly pressed cabbage juice. Works wonders with any GI issues. Google around and you’ll find it helped a lot of people. Good luck !

arTistapple profile image
arTistapple

My sister did it and it went by relatively ok. She was having gall bladder issues for quite a long time beforehand. However although eradicated it did not stop her gallbladder issues and had to have that removed.

Brightness14 profile image
Brightness14

I used Organic, Oil of Oregano and it worked but Cedarwood Oil is the best for H Pylori. The Oregano cleared up the parasite in my Kidney back in 2022.

Crankyoldbag profile image
Crankyoldbag

The functional doctor am using thinks i need to get rid of the h pylori before attacking the sibo. Metronidazole is supposed to get rid of one type of sibo. Yes if i’ve tried everything then it seems the only option. I would never use ppi’s normally as not necessary. There are some probiotics that are apparently ok with sibo. A soil based one called bacillus coagulans which i read about on Chris Kresser website. Also s.boulardii is supposed to be ok for sibo and for using with abx.

Espeegee profile image
Espeegee

you could try Ivermectin or Panacur? Both kill parasites.

Crankyoldbag profile image
Crankyoldbag in reply toEspeegee

Its not a parasite its a bacteria

Espeegee profile image
Espeegee in reply toCrankyoldbag

I know but there is a good chance ivermectin will work.

StitchFairy profile image
StitchFairy in reply toEspeegee

Panacur? I thought that was for worming animals!

Espeegee profile image
Espeegee in reply toStitchFairy

Indeed it is but like Ivermectin it seems it is diverse in its ability to fix other problems. I have my husband on both as he’s having chemo, he saw his consultant after 3 rounds and he said his recovery was so impressive he felt he’d make a complete recovery. His blood proteins created by cancer have dropped from 254 at the start to 16, he’s holding his own so we’re quite optimistic. Given that he was diagnosed with stage 4 with liver mets, spots on his lungs and aorta and a lesion on his sacrum I’m very willing to believe that the Ivermectin and Fenbendazole (Panacur) are doing a good job.

Crankyoldbag profile image
Crankyoldbag

Its part of the protocol called Pylera. To protect the stomach i guess. Yes only as part of protocol. I have methane and hydrogen sibo. It started as methane last year and is now both. I don’t know how my gut will recover from abx without probiotics… this is why i’ve been so reluctant to do it so far as i knew there was an issue with abx and SIBO

Bertwills profile image
Bertwills

Be wary of taking tetracycline. I took it for severe acne & i blame it for my hypothyroidism. It can cause serious damage to your thyroid. Maybe you already don’t have much thyroid activity but if you do i wouldn’t take it.

Oregano oil worked for me & manuka honey worked for my husband.

Espeegee profile image
Espeegee

I tried Berberine twice, it didn’t suit me at all which is annoying because I bought a large bag of it lol

Crankyoldbag profile image
Crankyoldbag in reply toEspeegee

Apparently Berberine can be challenging for the gut.

Espeegee profile image
Espeegee in reply toCrankyoldbag

I’d agree with that.

Crankyoldbag profile image
Crankyoldbag

Just to update you, i just spoke to my gut health practitioner in the uk and she said going from my last GI Map my system isn’t strong enough to make the quadruple abx a success although she isn’t totally against them as they have bismuth in. Wants to build up adrenal support, sleep (which is crap atm) do a 4 point saliva test and then decide. Otherwise she uses ADP oregano and other stuff. Says she has an 80% success rate with h.pylori

Espeegee profile image
Espeegee

It seemed to create a feeling of uneasiness and anxiety. I stopped taking it for a while and then restarted and had the same feelings again so stopped. It might be that the dose was too high but I wasn’t sure it was helping anyway.

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