Advice yet again please: Hello, I posted 1... - Thyroid UK

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Advice yet again please

4youreyesonly profile image
12 Replies

Hello, I posted 10 months ago with some bloods and got some good advice. I decided to wait and see how things went . Since then my tsh dropped a bit but still above range , been done a few times but these are the ones I have to hand .August 24 , Tsh 4.6 (0.3-4.5) T4 14.6(10-22) Done again 9 December Tsh 5.9(0.3-4.5) T4 14.5(10.0-22.0) T3 5.3(3.1-6.8) shocked I got T3 done by the drs.

B12 574(150-1000) Folate 20.8(2.0-18.8) Vitamin D 85. I supplement B12 and Vit d. Have to take folic acid with my methotrexate .Having more symptoms especially back pain , dr is happy to trial me 25 mg , question is should I give it ago now or still wait ? Is the T3 still too good .Thank you

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Buddy195 profile image
Buddy195Administrator

As TSH should be under 2, with many members reporting they feel better when this drops below 1, I would certainly trial the small dose of Levo offered to see if this alleviates any symptoms. As this is such a small starter dose, it’s likely you may need a further increase to get TSH under 2 / FT4 higher in range.

SlowDragon profile image
SlowDragonAmbassador

Looking at previous posts you have high thyroid antibodies confirming autoimmune thyroid disease

And usually very low ferritin level

When were iron and ferritin levels last tested

Request full iron panel via GP or test privately

Never supplement iron without doing full iron panel test for anaemia first and retest 3-4 times a year if self supplementing.

It’s possible to have low ferritin but high iron

Test early morning, only water to drink between waking and test. Avoid high iron rich dinner night before test

If taking any iron supplements stop 5-7 days before testing

Medichecks iron panel test

medichecks.com/products/iro...

Osteoporosis and iron deficiency

healthunlocked.com/thyroidu...

dr is happy to trial me 25 mg , question is should I give it ago now or still wait ?

How do you feel?

25mcg is low starting dose Levo because of your age. It will need increasing several times over coming months

4youreyesonly profile image
4youreyesonly in reply toSlowDragon

Hello, ferritin always seems low dispute upping my protein level can manage liver pate but not livers .Iron done in August serum iron level 19(11.0-32) Serum transferrin 2.3(2.0-3.6) Transferrin sat 32%(20.0-55.0) I feel unwell , not like myself at all . Have palpitations and ectopic beats dr is letting me have echocardiogram. Hot flushes again ,I’m 62 . Not sleeping well , low mood . , amongst others .

SlowDragon profile image
SlowDragonAmbassador in reply to4youreyesonly

Ferritin likely low because of thyroid

So likely to benefit in improving symptoms significantly once on decent level of replacement thyroid hormone

Palpitations and ectopic beats are hypo symptoms

Are you on gluten free or dairy free diet

4youreyesonly profile image
4youreyesonly in reply toSlowDragon

Thank you . No im not gluten or dairy free , blood test was negative

SlowDragon profile image
SlowDragonAmbassador in reply to4youreyesonly

It’s ALWAYS worth trying gluten free

Hashimoto's affects the gut and leads to low stomach acid and then low vitamin levels

Low vitamin levels affect Thyroid hormone working

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances.

Most common by far is gluten. Dairy is second most common.

A trial of strictly gluten free diet is always worth doing

Only 5% of Hashimoto’s patients test positive for coeliac but a further 81% of Hashimoto’s patients who try gluten free diet find noticeable or significant improvement or find it’s essential

A strictly gluten free diet helps or is essential due to gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and may slowly lower TPO antibodies

As test is negative you can consider trialing strictly gluten free diet 

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

drknews.com/changing-your-d...

Non Coeliac Gluten sensitivity (NCGS) and autoimmune disease

pubmed.ncbi.nlm.nih.gov/296...

The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported

nuclmed.gr/wp/wp-content/up...

In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned

restartmed.com/hashimotos-g...

Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.

Similarly few months later consider trying dairy free too. Approx 50-60% find dairy free beneficial

With loads of vegan dairy alternatives these days it’s not as difficult as in the past

Post discussing gluten

healthunlocked.com/thyroidu...

Recent research in China into food intolerances with Hashimoto’s

healthunlocked.com/thyroidu...

More interesting Chinese research on Hashimoto’s and leaky gut

nature.com/articles/s41598-...

Why gluten intolerance can upset cortisol levels

kalishinstitute.com/blog/gl...

Sleepman profile image
Sleepman

Your T3 is 60% of range which is good. That looks normal and that is the active hormone the body needs to function.

Just one T3 result but promising. T3 levels moves around through the day in everyone, more in some people than others though. Wise ones on forum advice 09:00 test on bloods with only water that morning to get consistent results.

As antibodies present I wonder about zero gluten, has Celiac test been done ? (does not always show on bloods though) It does not always affect peoples guts can just feel rubbish ?

Does your vit B12 supplement have biotin/B7 in it - that can swing the thyroid results around if levels are high in supplement (less than 150 micrograms per day is likely OK)

helvella.blogspot.com/p/hel...

tattybogle profile image
tattybogle in reply toSleepman

The fT3 is probably that good because high TSH causes the thyroid to increase the ratio of T3 to T4 that it produces... and also because high TSH has a small effect on boosting conversion of T4 to T3 . ( this is probably a sort of safety net , to try and compensate for lower T4 levels)

This means it is common to see reasonably good looking fT3 levels in early hypothyroidism . Eventually as thyroid damage worsens , i think you'd expect the T3 levels to falling too , but i've no idea how long that can take.

4youreyesonly profile image
4youreyesonly in reply totattybogle

Thank you for your reply , so should I just wait at the moment? before starting T4

tattybogle profile image
tattybogle in reply to4youreyesonly

if you are already feeling lousy, and since you already have autoimmune confirmed ,. i would give it a go.

but don't expect anything miraculous on 25mcg , as that is unlikely to be enough , but you have to start somewhere, so if GP is offering 25mcg i'd take that for starters and see how you go from there.

Sleepman profile image
Sleepman

I guess it could be T3 released from thyroid from attacks on it. Hashi swing as it is known.

tattybogle profile image
tattybogle in reply toSleepman

i think TSH would be expected to be low if that was the cause ( and fT4 also likely to be higher)... bit to be honest no one really has much detail about what happens during hashi swings cos there is not enough data to do any decent research.

very hard to do a study on T4/T3 swings in hypothyroidism when they don't routinely test T4/T3 ... and only test antibodies once at diagnosis etc

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