New to possible Subclinical hypothyroidism - Thyroid UK

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New to possible Subclinical hypothyroidism

BlueDaisy22 profile image
9 Replies

I have been feeling unwell with pins and needles in head face hands wrists and tops of feet since 2022. Also other random symptoms that made me think auto immune issues. Gp has done various tests that checked inflammatory markers and ruled out coeliac. Nevertheless i went gluten free as it seemed to improve things a little. My latest test results are below, I wondered if you could offer advice as to what i should ask in my upcoming telephone appointment to discuss the results.

Also, should I start other vitamins besides Vitamin D ?

Test results from 18.10.24.Gp has marked them as suggesting subclinical hypothyroidism. It looks like I definitely have some vitamin deficiencies. Dr did send message to say start vitamin D.

TSH 6.2 mIU/L (0.35 - 4.94) 127.5%Free T4 (fT4) 12.4 pmol/L (9.01 - 19.05) 33.8%

Folate - Serum 3.9 ug/L (3.10 - 20.50) 4.6%

Vitamin B12 389 nmol/L (187 - 883) 29.0%

Vitamin D 43.7 nmol/L (50 - 150) -6.3%

Ferritin 47 ug/L (20 - 204) 14.7%

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9 Replies
SlowDragon profile image
SlowDragonAdministrator

welcome to the forum

Was thyroid test early morning?

This gives highest TSH

All four vitamins are far too low

Work on improving and request thyroid and vitamin levels retested including THYROID ANTIBODIES for autoimmune thyroid disease in 2-3 months

Do you have any family members with autoimmune diseases

Roughly how old are you

Starting levothyroxine - flow chart

You need 2 separate tests with TSH over 5 …..plus symptoms…

gps.northcentrallondonccg.n...

About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high TPO and/or high TG thyroid antibodies

Autoimmune thyroid disease with goitre is Hashimoto’s

Autoimmune thyroid disease without goitre is Ord’s thyroiditis.

Both are autoimmune and generally called Hashimoto’s.

Significant minority of Hashimoto’s patients only have high TG antibodies (thyroglobulin)

NHS only tests TG antibodies if TPO are high

20% of autoimmune thyroid patients never have high thyroid antibodies and ultrasound scan of thyroid can get diagnosis

In U.K. medics hardly ever refer to autoimmune thyroid disease as Hashimoto’s (or Ord’s thyroiditis)

BlueDaisy22 profile image
BlueDaisy22 in reply toSlowDragon

Thank you for all this information. My blood test was about 10.30 am.

SlowDragon profile image
SlowDragonAdministrator

Low vitamin levels tend to lower TSH and can cause symptoms in their own right

Only add one vitamin supplement at a time and wait 10-14 days to assess before adding another

GP only obligated to treat below range results

Technically your vitamin D below 50nmol

GP should prescribe 1600iu everyday for 6 months

But likely easier to self treat at higher dose …..trying 2000iu or 3000iu daily

Retest in 2-3 months

NHS Guidelines on dose vitamin D required

panmerseyapc.nhs.uk/media/2...

GP will often only prescribe to bring vitamin D levels to 50nmol.

Some areas will prescribe to bring levels to 75nmol or even 80nmol

leedsformulary.nhs.uk/docs/...

GP should advise on self supplementing if over 50nmol, but under 75nmol (but they rarely do)

mm.wirral.nhs.uk/document_u...

But improving to around 80nmol or 100nmol by self supplementing may be better

pubmed.ncbi.nlm.nih.gov/218...

vitamindsociety.org/pdf/Vit...

Once you Improve level, very likely you will need on going maintenance dose to keep it there.

Test twice yearly when supplementing

Can test via NHS private testing service

vitamindtest.org.uk

Vitamin D mouth spray by Better You is very effective as it avoids poor gut function.

There’s a version made that also contains vitamin K2 Mk7.

One spray = 1000iu

amazon.co.uk/BetterYou-Dlux...

It’s trial and error what dose we need, with thyroid issues we frequently need higher dose than average

Vitamin D may prevent Autoimmune disease

newscientist.com/article/23...

Web links about taking important cofactors - magnesium and Vit K2-MK7

Magnesium best taken in the afternoon or evening, but must be four hours away from levothyroxine

betterbones.com/bone-nutrit...

medicalnewstoday.com/articl...

livescience.com/61866-magne...

sciencedaily.com/releases/2...

Recipe ideas

bbc.co.uk/food/articles/mag...

Interesting article by Dr Malcolm Kendrick on magnesium

drmalcolmkendrick.org/categ...

Vitamin K2 mk7

betterbones.com/bone-nutrit...

healthline.com/nutrition/vi...

BlueDaisy22 profile image
BlueDaisy22 in reply toSlowDragon

Thank you, it is super helpful to see how to approach this systematically.

SlowDragon profile image
SlowDragonAdministrator

Folate - Serum 3.9 ug/L (3.10 - 20.50) 4.6%

Vitamin B12 389 nmol/L (187 - 883) 29.0%

Obviously these are very low

Are you vegetarian or vegan?

Low B12 symptoms including pins and needles

b12deficiency.info/signs-an...

methyl-life.com/blogs/defic...

NICE guidelines on B12 and testing

healthunlocked.com/redirect...

With serum B12 result below 500, (Or active B12 below 70) recommended to be taking a separate B12 supplement

A week later add a separate vitamin B Complex 

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

If Vegetarian or vegan likely to need ongoing separate B12 few times a week

Highly effective B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

In-depth article on different forms of B12

perniciousanemia.org/b12/fo...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

perniciousanemia.org/b12/le...

And why aiming to keep B12 over 500 recommended

perniciousanemia.org/b12/le...

Great reply by @humanbean on B12 here

healthunlocked.com/thyroidu...

Low folate

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

B vitamins best taken after breakfast

Igennus B complex popular option. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose and may need separate methyl folate couple times a week

Post discussing different B complex

healthunlocked.com/thyroidu...

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule) Thorne can be difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 5-7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue separate B12

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

BlueDaisy22 profile image
BlueDaisy22 in reply toSlowDragon

Thank you. I am not vegetarian or vegan. I gave up gluten about a year ago and suspect this affects vitamin b in diet. My b12 level was at low end of the range when I first had pins and needles but gp said it was fine so I did not realise it needed to go up.P.s. I try to eat a healthy diet that has variety and lots of fruit and vegetables and meat and fish and dairy. I avoid ultra processed. So I think I am not absorbing well as you say.

Jaydee1507 profile image
Jaydee1507Administrator

Welcome to the group and thank you for completing your profile.

Your thyroid results do show subclinical hypothyroidism with raised TSH and in range FT4. This can result in quite some symptoms although doctors dont often acknowledge this.

Would recommend retesting in 3-4 months. You can be diagnosed and begin treatment following 2 raised TSH levels 3 months apart on the NHS.

Recommended blood test protocol: Test at 9am (or as close as possible), fasting & no biotin containing supplements for 3-7 days (Biotin can interfere with thyroid blood results as it is used in the testing process).

Testing like this gives consistency in your results and will show stable blood levels of hormone and highest TSH which varies throughout the day.

Low thyroid hormone levels cause low stomach acid which mean we dont absorb vitamins well from food. This would explain your low vitamin results.

Vitamin D should be around 100 - 150. Buy one that includes vit K2 to help it go to your bones. Some are available in oil or you can take it with an oily meal for better absorption. Many members like the ‘Better You’ range of mouth sprays that contain both bit D & K2. Use this calculator to work out how much to take to get your level to 100-150. Most people need a minimum of 3,000iu per day.grassrootshealth.net/projec...

Ferritin should be around 90 - 100 for best use of thyroid hormone. Suggest increasing iron rich foods in diet and eating them often. Chicken livers, pate, red meat etc

Link with ideas for dietary iron:

dailyiron.net/

Are you vegan or vegetarian? If not:

B12 - do you have symptoms of B12 deficiency? The reference range for B12 is very wide and cut off point too low. theb12society.com/signs-and...

If you do then you should discuss this with your doctor for further tests for Pernicious Anaemia.

If not, then start with a methyl B12 sublingual spray or lozenge for a week, then add a good B complex. Once you run out of the separate B12 just continue with the B complex.

cytoplan.co.uk/vitamin-b12-...

amazon.co.uk/Better-You-Boo...

B complex suggestions: Slightly cheaper options with inactive B6:

amazon.co.uk/Liposomal-Soft...

Contains B6 as P5P an active form:

bigvits.co.uk/thorne-resear...

healf.com/products/basic-b-...

Explanation about the different forms of B6:

helvella.blogspot.com/p/hel...

B complex comparison spreadsheet:

healthunlocked.com/thyroidu...

Raising vitamin levels before beginning treatment can really help symptoms in the mean time.

BlueDaisy22 profile image
BlueDaisy22 in reply toJaydee1507

Thank you so much. I am going through all the advice.

SlowDragon profile image
SlowDragonAdministrator

.

cks.nice.org.uk/topics/anae...

Serum ferritin level is the biochemical test, which most reliably correlates with relative total body iron stores. In all people, a serum ferritin level of less than 30 micrograms/L confirms the diagnosis of iron deficiency

Never supplement iron without doing full iron panel test for anaemia first and retest 3-4 times a year if self supplementing.

It’s possible to have low ferritin but high iron

Test early morning, only water to drink between waking and test. Avoid high iron rich dinner night before test

If taking any iron supplements stop 5-7 days before testing

Medichecks iron panel test

medichecks.com/products/iro...

Look at increasing iron rich foods in diet

Eating iron rich foods like liver or liver pate once a week plus other red meat, pumpkin seeds and dark chocolate, plus daily orange juice or other vitamin C rich drink can help improve iron absorption

List of iron rich foods

dailyiron.net

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