TPO antibodies/TSH in range now : Apologies if... - Thyroid UK

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TPO antibodies/TSH in range now

CarolineCaroline profile image
5 Replies

Apologies if some of. the following information is duplicate from my previous other. posts.

Over the last 18 months my Thyroid blood tests have shown the following results . I’m not on any treatment and started with symptoms 2 years ago or so with weight loss, fatigue, temperature sensitivity and brain fog.

April 23

TSH O.01 (0.34 - 5.6)

T4 13.2 (7.5 - 21.1)

T3 4.2

Nov 23

TSH 4.73 - Hospital Test No range given

T4 8.8

T3 5.1

TPO antibodies 673

Feb 24

TSH 6.09 (0.34 - 5.6)

T4 10.5 (7.5 - 21.1)

April 24

TSH 4.89 (0.34 - 5.6)

T4 10.7 (7.5 - 21.1)

Dr confirmed I have a Thyroid nodule which after a number of ultrasounds has been confirmed as benign.

The issue is, I still don’t feel myself, at all, my energy levels are my main issue and temperature sensitivities. Prior to all of this starting I had more energy . I was a regular gym goer and every night after work would be out walking/running or the gym. I’m pushing to do a few classes, but it’s so difficult both in the class and then once home. Im completely burnt out. I have never struggled like this with fatigue prior to these physical changes.

Now that my TSH levels have returned to normal range. Do the high TPO antibodies indicate that I have an autoimmune condition or could the high TPO antibodies result been because of my low TSH.

I have seen an Endocrinologist once prior to all my tests being conducted.

His last letter mentioned I have gone from sub-clinical hyperthyroidism to sub-clinical hypothyroidism

Has anyone gone through anything similar please that can share their experiences.

I am now taking Vitamin D + K3 oral spray to pick up any vitamin deficiencies and I eat a reasonably healthy diet and I take plenty of exercise and do resistance training.

Just want to get back to my old self.

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CarolineCaroline
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5 Replies
SlowDragon profile image
SlowDragonAdministrator

This is absolutely typical of hypothyroid autoimmune disease. Extremely common to initially start with transient hyperthyroid type results (as thyroid cells break down under autoimmune attack releasing excess thyroid hormones)

This is not true hyperthyroidism.

Bloods then swing to be increasingly hypothyroid, which is where you are now

How low was vitamin D

How much vitamin D are you taking

ESSENTIAL to also test folate, B12 and ferritin, these are also likely low

Low thyroid hormone levels leads to LOW stomach acid and poor nutrient absorption, with low vitamin levels as direct result

ALWAYS test thyroid levels early morning, ideally before 9am, only drinking water between waking and test

This gives highest TSH

Important to maintain OPTIMAL vitamin levels

Starting levothyroxine - flow chart

Two tests with TSH over 5 and symptoms and high thyroid antibodies GP could/should start you on levothyroxine

gps.northcentrallondonccg.n...

Get vitamin levels tested and optimal

Then retest thyroid again

Meanwhile get coeliac blood test done

CarolineCaroline profile image
CarolineCaroline in reply to SlowDragon

Thank you. I am very grateful to you for taking the time to respond in detail to my post.

I have checked my Vitamin D levels

Vitamin D3 61 (60 - 150)

Vitamin D 74 (70 - 150) Nov 23

I have been taking D3000 + K2 the Better for you oral spray

These are the blood results over last 18 months for

Serum Folate level

20.0 (3.1 - 19.9) Feb 24

7.7 (3.1 - 19.9) March 23

Serum Vitamin B12

316 ( 110 -914) March 23

631 (110 - 914) Feb 24 after taking D3 supplement

Serum Ferritin Level

Result 52.0 (10.0 - 180)

Result 53.0 (10.0 - 180.0)

As I have currently only had one TSH test result over 5.0.

Does this mean it unlikely that I will be offered medication. If I stay in range then will it be a waiting game until another TSH result over 5.0.

I am going to approach my GP for a coeliac blood test and then I can start changing my diet to Gluten free. I just want to find some way of feeling my “normal” once again.

SlowDragon profile image
SlowDragonAdministrator in reply to CarolineCaroline

Vitamin D might be better nearer 100nmol

Folate and B12 good now

Ferritin, look at increasing iron rich foods to get ferritin at least over 70

Book new thyroid test 2-3 months after going strictly gluten free

SlowDragon profile image
SlowDragonAdministrator

Poor gut function with Hashimoto’s can lead leaky gut (literally holes in gut wall) this can cause food intolerances.

Most common by far is gluten. Dairy is second most common.

A trial of strictly gluten free diet is always worth doing

Only 5% of Hashimoto’s patients test positive for coeliac but a further 81% of Hashimoto’s patients who try gluten free diet find noticeable or significant improvement or find it’s essential

A strictly gluten free diet helps or is essential due to gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and may slowly lower TPO antibodies

While still eating high gluten diet ask GP for coeliac blood test first as per NICE Guidelines

nice.org.uk/guidance/ng20/c...

Or buy a test online, about £20

Assuming test is negative you can immediately go on strictly gluten free diet 

(If test is positive you will need to remain on high gluten diet until endoscopy, maximum 6 weeks wait officially) 

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

drknews.com/changing-your-d...

Non Coeliac Gluten sensitivity (NCGS) and autoimmune disease

pubmed.ncbi.nlm.nih.gov/296...

The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported

nuclmed.gr/wp/wp-content/up...

In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned

restartmed.com/hashimotos-g...

Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.

Similarly few months later consider trying dairy free too. Approx 50-60% find dairy free beneficial

With loads of vegan dairy alternatives these days it’s not as difficult as in the past

Post discussing gluten

healthunlocked.com/thyroidu...

CarolineCaroline profile image
CarolineCaroline in reply to SlowDragon

Thank you very much for taking the time to respond to my post and questions

I am going to approach my Gp to arrange a blood test for coeliac.

I will do whatever is needed to try return to feeling my version of “normal “ again

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