Post Thyroidectomy and a confused GP - Thyroid UK

Thyroid UK

141,243 members166,489 posts

Post Thyroidectomy and a confused GP

PittyKitty profile image
5 Replies

TSH 8.19 mIU/L (0.570 - 3.600) 251.5%

Free T4 (fT4) 12.4 pmol/L (≤ 14)

My results are as above , had a call from my GP who doesn’t understand my test results and is referring me to an endo.

I’m post RAI (2006) post thyroidectomy (March 2024) on 125 micrograms Levo daily.

Pre thyroidectomy I was unmedicated as my tsh was nearly 0 and my T4 low ( my Endo did not know what I should take ) as my thyroid had regrown after RAI.

I am also clueless but really would appreciate a bit of information to take to the endo if anyone could suggest what could be going on.

Written by
PittyKitty profile image
PittyKitty
To view profiles and participate in discussions please or .
Read more about...
5 Replies
SlowDragon profile image
SlowDragonAdministrator

on 125 micrograms Levo daily.

Was test done early morning and last dose levothyroxine 24 hours before test

Are you taking Levo on empty stomach and nothing apart from water for at least an hour after

No other medications or supplements within 2 hours

Some like iron, calcium, vitamin D, HRT or ppi not within 4 hours

which brand of levothyroxine

How long have you been on this dose

PittyKitty profile image
PittyKitty in reply toSlowDragon

Test was done at 11.15 , last dose was day before .

Take levo always with a glass of water and wait an hour before any other food .

Take vitamin D usually with food one hour after Levo

levothyroxine brand is different nearly every time

11 months

SlowDragon profile image
SlowDragonAdministrator in reply toPittyKitty

Is vitamin D a mouth spray or tablets

If tablets move it to evening meal

Which brand levo suits you best

Many people find Levothyroxine brands are not interchangeable.

Most easily available (and often most easily tolerated) are Mercury Pharma or Accord

Mercury Pharma make 25mcg, 50mcg and 100mcg tablets 

Mercury Pharma also boxed as Eltroxin. Both often listed by company name on pharmacy database - Advanz

Accord only make 50mcg and 100mcg tablets. Accord is also boxed as Almus via Boots, 

Wockhardt is very well tolerated, but only available in 25mcg tablets. Some people remain on Wockhardt, taking their daily dose as a number of tablets 

Lactose free brands - currently Teva or Vencamil only

Teva makes 25mcg, 50mcg, 75mcg and 100mcg

Many patients do NOT get on well with Teva brand of Levothyroxine.

Teva is lactose free.But Teva contains mannitol as a filler instead of lactose, which seems to be possible cause of problems. Mannitol seems to upset many people, it changes gut biome 

Teva is the only brand that makes 75mcg tablet.

So if avoiding Teva for 75mcg dose ask for 25mcg to add to 50mcg or just extra 50mcg tablets to cut in half

But for some people (usually if lactose intolerant, Teva is by far the best option)

Aristo (currently 100mcg only) is lactose free and mannitol free.

March 2023 - Aristo now called Vencamil

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

List of different brands available in U.K.

thyroiduk.org/if-you-are-hy...

Posts that mention Teva

healthunlocked.com/search/p...

Teva poll

healthunlocked.com/thyroidu...

Once you find a brand that suits you, best to make sure to only get that one at each prescription.

Watch out for brand change when dose is increased or at repeat prescription.

Government guidelines for GP in support of patients if you find it difficult/impossible to change brands

gov.uk/drug-safety-update/l...

If a patient reports persistent symptoms when switching between different levothyroxine tablet formulations, consider consistently prescribing a specific product known to be well tolerated by the patient.

If symptoms or poor control of thyroid function persist (despite adhering to a specific product), consider prescribing levothyroxine in an oral solution formulation.

academic.oup.com/jcem/artic...

Physicians should: 1) alert patients that preparations may be switched at the pharmacy; 2) encourage patients to ask to remain on the same preparation at every pharmacy refill; and 3) make sure patients understand the need to have their TSH retested and the potential for dosing readjusted every time their LT4 preparation is switched (18).

And here

pharmacymagazine.co.uk/clin...

Discussed here too

healthunlocked.com/thyroidu...

SlowDragon profile image
SlowDragonAdministrator in reply toPittyKitty

Request 25mcg dose increase in Levo

Retest again in 6-8 weeks

Meanwhile get vitamin D, folate, B12 and ferritin levels tested

SlowDragon profile image
SlowDragonAdministrator

How much do you weigh in kilo

pathlabs.rlbuht.nhs.uk/tft_...

Guiding Treatment with Thyroxine:

In the majority of patients 50-100 μg thyroxine can be used as the starting dose. Alterations in dose are achieved by using 25-50 μg increments and adequacy of the new dose can be confirmed by repeat measurement of TSH after 2-3 months.

The majority of patients will be clinically euthyroid with a ‘normal’ TSH and having thyroxine replacement in the range 75-150 μg/day (1.6ug/Kg on average).

The recommended approach is to titrate thyroxine therapy against the TSH concentration whilst assessing clinical well-being. The target is a serum TSH within the reference range.

……The primary target of thyroxine replacement therapy is to make the patient feel well and to achieve a serum TSH that is within the reference range. The corresponding FT4 will be within or slightly above its reference range.

The minimum period to achieve stable concentrations after a change in dose of thyroxine is two months and thyroid function tests should not normally be requested before this period has elapsed.

TSH should be under 2 as an absolute maximum when on levothyroxine

gponline.com/endocrinology-...

Graph showing median TSH in healthy population is 1-1.5

web.archive.org/web/2004060...

Comprehensive list of references for needing LOW TSH on levothyroxine

healthunlocked.com/thyroidu....

onlinelibrary.wiley.com/doi...

If symptoms of hypothyroidism persist despite normalisation of TSH, the dose of levothyroxine can be titrated further to place the TSH in the lower part of the reference range or even slightly below (i.e., TSH: 0.1–2.0 mU/L), but avoiding TSH < 0.1 mU/L. Use of alternate day dosing of different levothyroxine strengths may be needed to achieve this (e.g., 100 mcg for 4 days; 125 mcg for 3 days weekly).

Not what you're looking for?

You may also like...

Bloods Post Partial Thyroidectomy

hi everyone, I was in touch previously at the end of last year and had a goitre which i got...
Void1234 profile image

Non-zero Anti-Tg after total thyroidectomy

Hello again, actually I posted a result about my TSH level increase hours ago but while looking in...
Renadom profile image

Post thyroidectomy.

Am now three weeks past total thyroidectomy and removal of numerous lymph glands. First week on...
HelenaJ profile image

Prozac after thyroidectomy?

6 months post total thyroidectomy and my tsh still high (10), being treated on T4 only and my endo...
Elektra18 profile image

Test results post partial thyroidectomy

Hi all I had a hemi thyroidectomy 6 weeks ago (large benign single nodule) and, although I...
Julesboz profile image

Moderation team

See all
SlowDragon profile image
SlowDragonAdministrator
Jaydee1507 profile image
Jaydee1507Administrator
RedApple profile image
RedAppleAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.