Differing TSH results: Hello Firstly, thank you... - Thyroid UK

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Differing TSH results

Amtired profile image
17 Replies

Hello

Firstly, thank you for all the useful information and advice.

I started taking 50mcg of levothyroxine in June and had a follow up blood test at the end of August which showed my TSH was 2.54 (0.27 - 4.2). The GP did not increase my dosage of thyroxine and I did not have the energy to push for it!

I have become very tired again in September/October and saw a new GP in October, who requested another blood test. I also decided to do a thyroid test with Monitor My Health as they would also check FT4 and 3 levels.

I did the Monitor My Health test at 8am, fasting, stopped B vits a week beforehand and having taken thyroxine 24+ hours beforehand. The results are:

TSH 2.59 (0.27 - 4.2)

FT4 14.4 (12 - 22) 24% through range

FT3 4.1 (3.1 -6.8) 27% through range

At 9am the same day I had blood taken at the hospital and the results are:

TSH 2.09 (0.27 - 4.2)

FT4 14.5 (10.8 - 25.5) 25%

I do not understand why there would be a difference in TSH levels, any advice would be welcome. Should my levothyroxine be increased?

Thank you!

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Amtired
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17 Replies
greygoose profile image
greygoose

Well, the difference is only 0.09, which is nothing in TSH terms, but probably explained by the difference in time. A drop of 0.09 in one hour sounds reasonable to me. :)

HealthStarDust profile image
HealthStarDust

I can share I have had the same issue. TSH drops throughout the day, but given my FT4 was different between the two, I am not sure I have as much faith in finger pricks tests.

Jaydee1507 profile image
Jaydee1507Administrator

Its really hard having the energy to be proactive in your own healthcare when you don't have any spare energy at all. You do have to find it from somewhere though otherwise you will remain that way.

You could take someone else along to support you or speak for you at the appointment. Perhaps try a different more helpful and open minded GP too.

Many GPs are very happy to have TSH within the normal range but this is far from good enough and will not make us well.

How have you got on tackling low vitamin levels? You had some good advice on a previous post here: healthunlocked.com/thyroidu...

Regarding differing TSH levels, we are not machines. There are multiple factors including different times of day and different labs, what you have eaten etc. Its a tiny difference and nothing to take any notice of.

Good luck getting your required increase.

Amtired profile image
Amtired in reply to Jaydee1507

Thanks for your reply Jaydee. Most of my appointments have been phone calls which makes it difficult to take someone else along to. I have changed GP surgeries and have actually seen a GP!!

Re vitamins, I am now taking Thorne Basic B, BetterYou Vitamin D & K2, Thorne citramate and B12.

I will push for a increase in dose this week!

Jaydee1507 profile image
Jaydee1507Administrator in reply to Amtired

Don't give up. If you fail this time then regroup and try again until you get it. Its the squeaky wheel that gets oiled. 😉

Amtired profile image
Amtired in reply to Jaydee1507

Just thought I would let you know that I have had a phone call with a GP and I am now taking 75mcg of levothyroxine 😀

Only after the GP told me that my TSH level was fine and I didn't need a thyroxine dose increase. If I was tired etc again there was something else going on. She could recommend a book to read, although she couldn't remember the title, and increasing the thyroxine wasn't getting to the reason behind my auto immunity!

I expressed my frustration, that I felt similar to before I commenced the levothyroxine and suggested that I try 75mcg to see how I got on. She agreed muttering that my TSH might be too low next time I have a blood test!

Jaydee1507 profile image
Jaydee1507Administrator in reply to Amtired

That is excellent! It never hurts to ask for an increase.

You may even need further increases but get the test booked in for 6-8 weeks time at 9am or earlier. Remember not to take your levo that morning. Take it after the test that day.

Well done!

SlowDragon profile image
SlowDragonAdministrator

Push for next 25mcg increase in levothyroxine now

Did you get full iron panel test results

As vegetarian with deficient ferritin level you likely need iron supplements

Are you now taking separate B12 and vitamin B complex

Amtired profile image
Amtired in reply to SlowDragon

Thanks Slowdragon, will push for an increase in dosage when I speak to GP.

Am taking separate B12 and B complex. I also ensure that I have iron rich foods at every meal and do sometimes use supplements. I do not think I have had a full iron panel blood test.

Will also have another read through of previous links.

SlowDragon profile image
SlowDragonAdministrator

As vegetarian with Hashimoto’s you will almost certainly need iron supplements

Never supplement iron without doing full iron panel test for anaemia first and retest 3-4 times a year if self supplementing. It’s possible to have low ferritin but high iron

Test early morning, only water to drink between waking and test. Avoid high iron rich dinner night before test

Medichecks iron panel test

medichecks.com/products/iro...

See humanbean reply on iron testing when on iron supplements on this post

healthunlocked.com/thyroidu...

Amtired profile image
Amtired in reply to SlowDragon

Hello Slow Dragon, I have just got the results from a Monitor My Health anaemia test.

They are:

HB 133g/l (normal)

Ferritin 27ug/L (normal)

TSAT 18% (normal)

Active B12 47pmmol/L (normal)

Folate 20 ug/L (normal)

There are no ranges given for these results and all bar folate are very low down their 'normal' graph.

I assume that these all need improving!

As ever, thank you all so much for your advice 💐

SlowDragon profile image
SlowDragonAdministrator in reply to Amtired

Ouch

Ferritin is deficient

B12 is insufficient

Folate….would need range

No vitamin D?

SlowDragon profile image
SlowDragonAdministrator

Starting with B12

Low B12 symptoms

b12deficiency.info/signs-an...

methyl-life.com/blogs/defic...

With serum Active B12 result below 70 (Or serum B12 below 500) recommended to be taking a separate B12 supplement and a week later add a separate vitamin B Complex 

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

As you are Vegetarian you will need ongoing separate B12 at least few times a week, if not every day

Highly effective B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance

Difference between folate and folic acid

healthline.com/nutrition/fo...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Other options

healthunlocked.com/thyroidu....

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue separate B12 until Active B12 is over 70 minimum

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

helvella.blogspot.com/p/hel...

academic.oup.com/nutritionr...

The present review of the literature regarding B12 status among vegetarians shows that the rates of B12 depletion and deficiency are high. It is, therefore, recommended that health professionals alert vegetarians about the risk of developing subnormal B12 status. Vegetarians should also take preventive measures to ensure adequate intake of this vitamin, including the regular intake of B12 supplements to prevent deficiency. Considering the low absorption rate of B12 from supplements, a dose of at least 250 μg should be ingested for the best results.3

Amtired profile image
Amtired in reply to SlowDragon

Due to previous advice when I joined the Forum I took a B12 supplement before starting a B Complex. I have been taking 1 Thorne Basic B Complex and Thorne Magnesium CitraMate tablet daily. 3 squirts of Better you D3 & K2 and 1 Nutrition Geeks Iron Energy + every other day.

Should I increase the Basic B and Iron Energy+ (which includes B12)?

The comments section on my report said that I 'do not have anaemia and have adequate levels of iron, Vit B12 and folate'!

SlowDragon profile image
SlowDragonAdministrator in reply to Amtired

no point taking any iron at same time as other supplements as iron will block absorption of everything else

Add a separate B12

I recommend Nature provides B12 drops

And a separate iron supplement at least 2 hours away from all other supplements and four hours away from levothyroxine

Amtired profile image
Amtired in reply to SlowDragon

Thanks, have been taking the iron supplement away from other supplements and will get some B12 drops.

SlowDragon profile image
SlowDragonAdministrator

HB 133g/l (normal)

uhcw.nhs.uk/download/client...

Ferritin 27ug/L

Aiming to improve to at least over 70 minimum

TSAT 18% (normal)

urmc.rochester.edu/encyclop....

Another measurement, called transferrin saturation, checks how many places on your transferrin that can hold iron are actually doing so. Normal values are 15% to 50%. In severe cases of iron-deficiency and anemia, this number may fall below 10%.

cks.nice.org.uk/topics/anae...

Serum ferritin level is the biochemical test, which most reliably correlates with relative total body iron stores. In all people, a serum ferritin level of less than 30 micrograms/L confirms the diagnosis of iron deficiency.

Never supplement iron without doing full iron panel test for anaemia first and retest 3-4 times a year if self supplementing. It’s possible to have low ferritin but high iron

Test early morning, only water to drink between waking and test. Avoid high iron rich dinner night before test

Medichecks iron panel test

medichecks.com/products/iro...

Look at increasing iron rich foods in diet

Eating iron rich foods like liver or liver pate once a week plus other red meat, pumpkin seeds and dark chocolate, plus daily orange juice or other vitamin C rich drink can help improve iron absorption

List of iron rich foods

dailyiron.net

Links about iron and ferritin

irondisorders.org/too-littl...

davidg170.sg-host.com/wp-co...

Great in-depth article on low ferritin

oatext.com/iron-deficiency-...

drhedberg.com/ferritin-hypo...

This is interesting because I have noticed that many patients with Hashimoto’s disease and hypothyroidism, start to feel worse when their ferritin drops below 80 and usually there is hair loss when it drops below 50.

healthunlocked.com/thyroidu...

Posts discussing Three Arrows as very effective supplement

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Iron patches

healthunlocked.com/thyroidu...

Thyroid disease is as much about optimising vitamins as thyroid hormones

healthunlocked.com/thyroidu...

restartmed.com/hypothyroidi...

Post discussing just how long it can take to raise low ferritin

healthunlocked.com/thyroidu...

Iron and thyroid link

healthunlocked.com/thyroidu...

Posts discussing why important to do full iron panel test

healthunlocked.com/thyroidu...

Good iron but low ferritin

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Chicken livers if iron is good, but ferritin low

healthunlocked.com/thyroidu...

Shellfish and Mussels are excellent source of iron

healthline.com/nutrition/he...

Iron deficiency without anaemia

healthunlocked.com/thyroidu...

Ferritin over 100 to alleviate symptoms

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Great research article discussing similar…..ferritin over 100 often necessary

ncbi.nlm.nih.gov/pmc/articl...

Low Iron implicated in hypothyroidism

healthunlocked.com/thyroidu...

Ferritin range on Medichecks

healthunlocked.com/thyroidu...

Inflammation affecting ferritin

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

We have received further information the lab about ferritin reference ranges. They confirm that they are sex dependent up to the age of 60, then beyond the age of 60 the reference range is the same for both sexes: 

Males 16-60: 30-400 ug/L

Female's: 16-60: 30-150

Both >60: 30-650 

The lower limit of 30 ug/L is in accordance with the updated NICE guidance and the upper limits are in accordance with guidance from the Association of Clinical Biochemists. ‘

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