Please could I have some advice about “normal” ... - Thyroid UK

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Please could I have some advice about “normal” vitamin levels?

Mollyfan profile image
10 Replies

I have just had some bloods done by my GP, all of which are in the normal range. Some are low in range and I would be grateful for any recommendations, especially from SlowDragon

Thanks.

Serum ferritin level 131 ug/L [30.0 -

250.0

Serum vitamin B12 level 267 ng/L [200.0

- 900.0

Serum folate level 6.4 ug/L [3.0 - 20.5];

Serum folate of less than 3 ug/L is used

as a

guide to indicate folate deficiency.

However,

there is an indeterminate zone with

folate levels

of 3-4.5 ug/L, so low folate should be

interpreted

as suggestive of deficiency and not

diagnostic.

Serum total 25-hydroxy vitamin D level

77 mol/L [50.0 - 200.0];

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Mollyfan profile image
Mollyfan
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SlowDragon profile image
SlowDragonAdministrator

Are you vegetarian or vegan?

What are your most recent TSH, Ft4 and Ft3 results

What vitamin supplements are you currently taking

B12 and folate both very low

Do you have Low B12 symptoms

b12deficiency.info/signs-an...

methyl-life.com/blogs/defic...

With serum B12 result below 500, (Or active B12 below 70) recommended to be taking a separate B12 supplement and a week later add a separate vitamin B Complex 

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

If Vegetarian or vegan likely to need ongoing separate B12 few times a week

B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

Low folate

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule)

Thorne currently difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

Other options

healthunlocked.com/thyroidu....

Igennus B complex popular option too. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue separate B12

Post discussing how biotin can affect test results

healthunlocked.com/thyroidu...

Mollyfan profile image
Mollyfan in reply to SlowDragon

Thank you so much for such a detailed reply!

I am not vegetarian or vegan and eat plenty of meat ( also lots of vegetables, cheese and fruit)

Results in June

TSH 0.03 ( 0.27-4.2)

FT4. 12.1 (12-22)

FT3 5.8 (3.1-6.8)

I am under a good endocrinologist and am taking Levi 100mcg plus liothyronine 20 mcg per day.

I usually take methyl folate 1000mcg per day, but deliberately didn’t for a couple of weeks to see what would happen. I also take vitamin D in the winter interestingly my B12 has dropped a lot and was almost 4 times higher in 2018

I am heterogeneous for MTHFR

Thank you so much for the recommendations, I will get on it! Of course, the GP is not interested as they are “ in range”

Thank you also for putting in so much time, it is invaluable

SlowDragon profile image
SlowDragonAdministrator in reply to Mollyfan

I would say you might want to experiment with increasing levothyroxine

Many of us on levothyroxine plus small dose T3 find we need both Ft4 and Ft3 at least 50-60% through range

FT4: 12.1 pmol/l (Range 12 - 22)

Ft4 extremely low at only 1.00% through range

FT3: 5.8 pmol/l (Range 3.1 - 6.8)

Ft3 good at 72.97% through range

I would think low B12 might be due to low Ft4

Mollyfan profile image
Mollyfan in reply to SlowDragon

Thank you….. my endocrinologist reduced my Levi by 25 mcg recently!

Sorry, I didn’t answer you. I have very non specific symptoms, sleepiness, joint pains and weight gain sine Levi reduced but non specifically B12 as far as I know.

I did discuss my folate with my dentist as I had mildly bleeding gums and a sore tongue. He did not believe it was related and lectured me about cleaning my teeth.

Hey ho! I intend to prove him wrong!

Thanks again.

SlowDragon profile image
SlowDragonAdministrator in reply to Mollyfan

Was this test done BEFORE dose reduction in levothyroxine or 6-8 weeks AFTER dose reduction?

Mollyfan profile image
Mollyfan in reply to SlowDragon

It was done after reduction. He wanted to get my TSH up a bit as it was 0.014. ……to be discussed at next appointment!

SlowDragon profile image
SlowDragonAdministrator in reply to Mollyfan

Well you now look under medicated

You could try increasing levothyroxine back to 112.5mcg daily and retest in 6-8 weeks

Might need to tweak further

Then (possibly) consider reducing T3 by 5mcg

Personally…..I only function on Ft4 and Ft3 at least over 60% through range…..but then TSH is 0.01

If I reduce levothyroxine or T3 enough to get TSH up to 0.02 ….stuck on sofa and legs stop working

I find it important to very finely tune both levothyroxine and T3 dose

Levothyroxine

125mcg daily too much = Ft4 right at top of range

112.5mcg daily too little = Ft4 right at bottom of range and TSH 0.02

125mcg 4 days and 112.5mcg 3 days = Ft4 at 18-19 ….about right for me but TSH 0.01

I recently tried reducing T3 from 20mcg to 15mcg …..made no difference to TSH whatsoever…..and felt worse ….so back on 20mcg (currently as 4 x 5mcg….but considering going back to 1 x 10mcg and 2 x 5mcg)

Mollyfan profile image
Mollyfan in reply to SlowDragon

It is so difficult! My endocrinologist is really lovely and I want to work with him, but I felt much better before.

On levo 125 mcg my fT4 was still only 14.. and TSH 0.014.

I am glad you have found your level and it is interesting that you are so sensitive. I believe that happens to quite a lot of people.

I will try really pushing my folate and B12 and see what he says. Also having mercury supply issues so had to switch to aristo which doesn’t help!

Like you, I have DIO2 polymorphism so will have to experiment.

Thanks!

serenfach profile image
serenfach

My last test for folate was 4.1 (3.1 - 22) but GP said it was fine. A year later I asked for another folate test while they were doing a blood test for diabetes which I dont have. It was refused as I was in range last year!

I now buy folate as if you dont need it, you just pee it out. It takes 3 to 4 months to raise the levels though.

Mollyfan profile image
Mollyfan in reply to serenfach

my GP did it this time because my medichecks results were always low. She is also very nice, but having come back “normal” I very much doubt she will do it again.

I think it is time for an evidence based full yearly check for people with thyroid disease ( and other autimmune diseases) but suppose the workload would be too great.

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