severe subclinical hyperthyroidism: Hi all. I am... - Thyroid UK

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severe subclinical hyperthyroidism

pkc05 profile image
20 Replies

Hi all. I am new to this site but I have been using the AF HealthUnlocked site for a number of years.

I have just had two blood tests one month apart and my TSH level was 0.04 and 0.07 mIU/L the higher figure is the latest blood test. My main symptoms are palputations, weightloss and tiredness. My T4 and T3 levels are ok. Oh, and crying is another one.

I have been researching this condition while I wait for my local endocrine team to advise my doctor on the best coarse of treatment. I feel they cannot prescribe medication accurately until they examine me to see if I have any abnormalities on my thyroid gland. The waiting time to be seen is in excess of 12 weeks. I am struggling now! I have just had a 72 hour episode of palputations. some of which, I think, were AF.

I think my diet is ok in the light I have AF. So, my main question is would it harm my current condition if is started taking kelp tablets?

Any info or links to clinical studies about this condition would be helpful at this stage of my diagnosis.

Kindest Regards

Paul Clark

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tattybogle profile image
tattybogle

Iodine has a very complex relationship with thyroid disorders... both in excess , and deficiency , iodine can have actions in both directions ........ ie. can worsen hypothyroidism and can also worsen hyperthyroidism ..... so yes it's possible that supplementing iodine with kelp tablets it at this stage could potentially make things worse.

Why are you thinking kelp tablets might be a good idea ?

post with collection of info about Iodine and it's potential effects on thyroid conditions here : healthunlocked.com/thyroidu...

pkc05 profile image
pkc05 in reply totattybogle

Thanks for the reply. I know kelp has iodine and I just thought it might be a natural way of getting some iodine into my system that is, to some extent, controllable. I would know if I got worse or better it would be the kelp tablets contributing in someway. My diet would stay as is. I understand the relationship with your iodine intake and thyroid function. I am baffled about the whole thing. I blame my dodgy genes, haha. Thanks for the link.

jimh111 profile image
jimh111

It will be very useful to measure your heart rate to see if it is high. Manually checking your pulse is helpful to see if it is rapid with a strong stroke. In the meantime your doctor could prescribe propranolol which as well as slowing the pulse reduces the rate of T4 conversion to T3 which is the active thyroid hormone.What are your fT3 and fT4 levels? Normal doesn't mean much if they are both in the upper part of their reference intervals.

pkc05 profile image
pkc05 in reply tojimh111

Hi, on 14th my SF T4 was 11.1 pmol/l my thyroid peroxidase TPO antibodies 10iu/mL. My FT3 was 4.7pmol/L. I think that's about in the middle for both. With having high blood pressure and high cholesterol I keep a regular check in my heart's rate and rhythm. The number of medicines are increasing year on year. At 65 I consider myself fit. However my body is trying to change that 😄 🤣. Thanks again for your reply.

Judithdalston profile image
Judithdalston in reply tojimh111

Sorry to but in, but does bisoprolol also affect T4 conversion? Any references to support idea re propranolol / bisoprolol to show drs?

jimh111 profile image
jimh111 in reply toJudithdalston

I haven't heard of it affecting deiodinase.

PurpleNails profile image
PurpleNailsAdministrator

Do you have results and ranges for both FT4 & FT3? Please add.

TPO and other antibodies have a (0-X) range or (>X.) Meaning unless levels exceed the limit it’s negative - over the threshold is a positive level.

TG antibodies should also be tested but as the TSH is low which usually occurs when. FT4 & FT3 are high (hyper) you should also have Thyroid stimulating antibodies tested.

TSI & TRab.

The other reason for low TSH in the absence of high FT4 & FT3 is that the pituitary is not functioning normally, but this usually causes very low levels. This is why is always best to test & show TSH, FT4 & FT3 all together.

pkc05 profile image
pkc05 in reply toPurpleNails

Hi, on 14th my SF T4 was 11.1 pmol/l my thyroid peroxidase TPO antibodies 10iu/mL. My FT3 was 4.7pmol/L. These are the only tests they have done. I am totally confused by the whole thing. I am so tired because I feel like I am on a fight or flight mode all the time. Sleep is a luxury at the moment.

PurpleNails profile image
PurpleNailsAdministrator in reply topkc05

FT4 of 11.1 is very low by some ranges. Below range in some cases. Were you told results but not given ranges? You need to obtain a printed copy of results of full results or set up online access so the can be Interpreted accurately.

pkc05 profile image
pkc05 in reply toPurpleNails

I have sent slow dragon one of the administration team all my blood test results. I not sure if you communicate with them. If you do ask them to forward it to you. Cheers.

PurpleNails profile image
PurpleNailsAdministrator in reply topkc05

When you reply to anyone the reply can be seen by members. (They will be notified of the reply if the reply it to them)

FT4: 11.1 pmol/l (Range 7.5 - 21.1) 26.47%

FT3: 4.7 pmol/l (Range 3.8 - 6.8) 30.00%

Both your thyroid hormone levels are in lower 3rd. You have low levels not high thyroid levels.

Doctors will need to monitor & if become under range will need to replace. Doctors sometimes focus on TSH and incorrectly suggest medications to lower further to “make” the TSH rise. This would not be a good idea.

Finding out why you TSH / FT4 & FT3 is low needs to be investigated first.

Haemoglobin A1c level - IFCC standardised 45 mmol/mol [26.0 - 41.0]; Above high reference limit

Your average blood glucose reading it high, whats being done about this?

Folate is ok but the rest of nutrients are not optimal

Serum folate level 10.5 ug/L [3.1 - 19.9]

Serum vitamin B12 level 267 ng/L [110.0 - 914.0]

vitamin D3 level 62 nmol/L [60.0 - 150.0]

Serum ferritin level 51 ng/mL [14.0 - 180.0].

greygoose profile image
greygoose

'Severe subclinical' is a contradiction in terms. What do you think makes it severe?

Subclincial hyperthyroidism is a nonsense, anyway. It's not the TSH that makes you hyper, it's very high levels of FT4 and FT3. But you say they are 'ok'. So, I presume they are somewhere within the so-called 'normal' range.

However, it's very difficult to say anything much without seeing a full thyroid panel - with ranges. Ranges vary from lab to lab so we need those that came with your results. We need to see:

TSH

FT4

FT3

TPO antibodies

Tg antibodies

TRAB

TSI

That will give us a much clearer picture of what is going on. It could be that rather than autoimmune hyperthyroidism - Graves' - you have autoimmune thyroidits - Hashi's/Ord's - which fluctuates between hypo and false hyper. This is often the case when Frees are in-range, but the TSH hasn't yet caught up with their level. It moves far more slowly.

If you don't have either of these conditions, it could be that you have a pituitary/hypothalamus problem, rather than a thyroid problem. But, we can only know if the correct testing is done. So, if your doctors won't co-operate by doing the correct testing - all the correct testing - then you could get them done privately, without having to involve a doctor.

And, btw, high cholesterol would suggest you are hypO rather than hypER. High cholesterol is usually caused by insufficient T3. :)

SlowDragon profile image
SlowDragonAdministrator

obviously need the ranges on Ft4 and FT3 as different labs have different ranges

Most common range for Ft4 is 12-22

Get actual ranges from reception at GP surgery tomorrow

Ask for printed copies of recent test results and ranges

AFib can be linked to being HYPO as well as HYPER thyroid

Strongly Recommend getting vitamin D, folate, ferritin and B12 levels tested

What’s your diet like

What other medications are you taking

ALWAYS test thyroid early morning, around 9am

pkc05 profile image
pkc05 in reply toSlowDragon

The following information is all I have

Specimen

Specimen Type: Blood

Specimen Reference#: 1

Collected: 09 Jun 2023

Received: 09 Jun 2023

Provider Sample ID: A298583/23

Pathology Investigations

Full blood count

Haemoglobin concentration 148 g/L [130.0 - 180.0]

Total white blood count 7.12 10*9/L [4.0 - 11.0]

Platelet count - observation 243 10*9/L [150.0 - 400.0]

Haematocrit 0.413 ratio [0.4 - 0.52]

Red blood cell count 4.71 10*12/L [4.5 - 6.5]

Mean cell volume 88 fL [80.0 - 99.0]

Mean cell haemoglobin level 31.4 pg [27.0 - 32.0]

Mean cell haemoglobin concentration 358 g/L [310.0 - 370.0]

Red blood cell distribution width 12.8 % [10.0 - 16.0]

Neutrophil count 4.24 10*9/L [1.8 - 7.5]

Lymphocyte count 1.82 10*9/L [1.0 - 4.0]

Monocyte count - observation 0.67 10*9/L [0.2 - 1.0]

Eosinophil count - observation 0.34 10*9/L [0.04 - 0.4]

Basophil count 0.05 10*9/L [0.02 - 0.11]

Percentage basophil count 0.7 %

Specimen Type: Serum

Specimen Reference#: 1

Collected: 30 Jun 2023

Received: 30 Jun 2023

Provider Sample ID: A341951/23

Pathology Investigations

LIVER BONE PROFILE

Serum total bilirubin level 15 umol/L [0.0 - 21.0]

Serum alanine aminotransferase level 16 iu/L [5.0 - 45.0]

Serum alkaline phosphatase level 67 iu/L [30.0 - 130.0]

Serum total protein level 69 g/L [60.0 - 80.0]

Serum albumin level 39 g/L [35.0 - 50.0]

Serum globulin level 30 g/L [23.0 - 41.0]

Serum calcium level 2.33 mmol/L

ADJUSTED CALCIUM 2.34 mmol/L [2.2 - 2.6]

Serum cholesterol level 5.4 mmol/L [1.5 - 5.5]

Serum lipid levels

Serum HDL cholesterol level 1.2 mmol/L [1.0 - 3.0]

Serum cholesterol level 5.4 mmol/L [1.5 - 5.5]

Serum triglyceride levels 1.38 mmol/L [0.5 - 2.0]

Serum cholesterol/HDL ratio 4.5 ratio

NON HDL CHOLESTEROL 4.2 mmol/L

Serum LDL cholesterol level 3.5 mmol/L

Specimen

Specimen Type: Serum

Specimen Reference#: 1

Collected: 09 Jun 2023

Received: 09 Jun 2023

Provider Sample ID: A298583/23

Specimen

Specimen Type: Blood

Specimen Reference#: 2

Collected: 09 Jun 2023

Received: 09 Jun 2023

Provider Sample ID: A298583/23

Pathology Investigations

Urea and electrolytes

Serum sodium level 136 mmol/L [133.0 - 146.0]

Serum potassium level 4.6 mmol/L [3.5 - 5.3]

Serum urea level 6.8 mmol/L [2.5 - 7.8]

Serum creatinine level 89 umol/L [64.0 - 104.0]

LIVER BONE PROFILE

Serum total bilirubin level 10 umol/L [0.0 - 21.0]

Serum alanine aminotransferase level 13 iu/L [5.0 - 45.0]

Serum alkaline phosphatase level 70 iu/L [30.0 - 130.0]

Serum total protein level 69 g/L [60.0 - 80.0]

Serum albumin level 42 g/L [35.0 - 50.0]

Serum globulin level 27 g/L [23.0 - 41.0]

Serum calcium level 2.35 mmol/L

ADJUSTED CALCIUM 2.32 mmol/L [2.2 - 2.6]

Serum cholesterol level 4.8 mmol/L [1.5 - 5.5]

Serum lipid levels

Serum HDL cholesterol level 1.0 mmol/L [1.0 - 3.0]

Serum cholesterol level 4.8 mmol/L [1.5 - 5.5]

Serum triglyceride levels 4.38 mmol/L [0.5 - 2.0]; Above high reference limit

Serum cholesterol/HDL ratio 4.8 ratio

NON HDL CHOLESTEROL 3.8 mmol/L

Serum LDL cholesterol level 1.8 mmol/L

GFR

GFR calculated abbreviated MDRD 78 mL/min/1.73m2 [90.0 - 500.0]; Below low reference limit

Serum free T4 level

Serum free T4 level 13.8 pmol/L [7.5 - 21.1]

Serum ferritin level 51 ng/mL [14.0 - 180.0]

Thyroid function test

Serum TSH level 0.04 miu/L [0.34 - 5.6]; Below low reference limit

Serum vitamin B12 level 267 ng/L [110.0 - 914.0]

Serum folate level 10.5 ug/L [3.1 - 19.9]

VITAMIN D

Serum 25-Hydroxy vitamin D3 level 62 nmol/L [60.0 - 150.0]

CHLORIDE & BICARBONATE

Serum bicarbonate level 28.1 mmol/L [22.0 - 29.0]

Serum chloride level 97 mmol/L [95.0 - 108.0]

REPORT COMMENTS Lipaemic sample at this level of lipaemia interpret the following resu

lts with caution: Iron and Magnesium

HBA1C.

Haemoglobin A1c level - IFCC standardised 45 mmol/mol [26.0 - 41.0]; Above high reference limit

Specimen Type: Serum

Specimen Reference#: 1

Collected: 14 Jul 2023

Received: 14 Jul 2023

Provider Sample ID: A370234/23

Pathology Investigations

FREE T3 4.7 pmol/L [3.8 - 6.8]

Specimen

Specimen Type: Serum

Specimen Reference#: 1

Collected: 14 Jul 2023

Received: 14 Jul 2023

Provider Sample ID: A370234/23

Pathology Investigations

Serum free T4 level

Serum free T4 level 11.1 pmol/L [7.5 - 21.1]

Thyroid function test

Serum TSH level 0.07 miu/L [0.34 - 5.6]; Below low reference limit

THYROID PEROXIDASE

TPO ANTIBODIES < 10 iu/mL [0.0 - 10.0]

SlowDragon profile image
SlowDragonAdministrator in reply topkc05

With having high blood pressure and high cholesterol I keep a regular check in my heart's rate and rhythm. The number of medicines are increasing year on year.

So number of questions first

What are your main symptoms

What other medications are you taking

Are you taking a PPI like Lansoprazole or Omeprazle

Are you vegetarian or vegan

Thyroid levels

July results

FT4: 11.1 pmol/l (Range 7.5 - 21.1)

Ft4 only 26.47% through range

FT3: 4.7 pmol/l (Range 3.8 - 6.8)

Ft3 only 30.00% through range

Low Ft4 and Ft3 are not being reflected in an increased TSH

TSH is abnormally low

Vitamin levels are very poor …B12 and ferritin especially

So if you’re not vegetarian or vegan or on PPI ……

then thyroid most likely the issue

Low TSH

Could be early stage Hashimoto’s (autoimmune hypothyroid disease) …..and TSH hasn’t caught up with sudden downward swing

Hashimoto’s frequently starts with transient hyperthyroid results and symptoms, as thyroid cells break down releasing excess thyroid hormones

You need BOTH TPO and TG thyroid antibodies tested together…..Will have to test privately as NHS won’t test TG antibodies unless TPO antibodies are high

Suggest you request An ultrasound scan of thyroid via GP or get privately (£100)

20% of Hashimoto's patients never have raised antibodies

Ultrasound can aid diagnosis

healthunlocked.com/thyroidu...

Paul Robson on atrophied thyroid - especially if no TPO antibodies

paulrobinsonthyroid.com/cou...

an ultrasound would also pick up another possibility…..a HOT nodule…..this make’s thyroid hormones regardless of TSH ……so TSH often low……but not normally as low as these results

Central hypothyroidism is also possibility…..

After ruled out other other options

Presumably you aren’t currently taking any vitamin supplements?

Optimal vitamin levels are

Vitamin D at least over 80nmol

Serum B12 at least over 500

Low B12 is extremely common as we get older

Ferritin at least over 100 for a bloke

Folate near top of range

SlowDragon profile image
SlowDragonAdministrator in reply topkc05

Other points

Haemoglobin A1c level - IFCC standardised 45 mmol/mol [26.0 - 41.0]; Above high reference limit

HBA1C slightly over range

Are you diabetic? Pre diabetic? On statins?

GFR calculated abbreviated MDRD 78 mL/min/1.73m2 [90.0 - 500.0]; Below low reference limit

GFR = kidney function

Low GFR strongly linked to hypothyroidism especially low Ft3

ncbi.nlm.nih.gov/pmc/articl...

The GFR is reversibly reduced (by about 40%) in more than 55% of adults with hypothyroidism[40] due to several reasons.

SlowDragon profile image
SlowDragonAdministrator

High cholesterol strongly linked to being HYPOTHYROID

nhs.uk/conditions/statins/c...

If you have an underactive thyroid (hypothyroidism), treatment may be delayed until this problem is treated. This is because having an underactive thyroid can lead to an increased cholesterol level, and treating hypothyroidism may cause your cholesterol level to decrease, without the need for statins. Statins are also more likely to cause muscle damage in people with an underactive thyroid.

Lalatoot profile image
Lalatoot

PKC vit d is low. The advice on here is a level of 100 is advisable. B12 again is low. Suggested level is 500. These levels are advised by folks on here who have read up and got experience of vitamins and supplementation. From your thyroid results you are not hyperthyroid. With an under range TSH a truly hyperthyroid patient would expect ft4 to be somewhere in 40s, 50s and higher with ft3 in the 20s. That is the pattern for hyper. Been there and got the t shirt!

Your results would suggest some sort of hypothyroidism. Perhaps a problem with the pituitary gland. Your ft4 is lower in range. In a normal person ft3 is slightly lower in range than ft4. Your ft3 is higher through its range than ft4 suggesting that the body is compensating for a too low ft4 by maximising ft3 levels.

With your ft4 and ft3 results you'd expect an elevated TSH to stimulate the thyroid. Your low TSH suggests a pituitary problem where the gland fails to stimulate the thyroid to produce more hormones.

SlowDragon profile image
SlowDragonAdministrator

Only start one vitamin supplement at a time

Suggest you start with vitamin D

Meanwhile get FULL thyroid test including BOTH thyroid antibodies for Hashimoto’s

Also both TPO and TG thyroid antibodies tested at least once

About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high thyroid antibodies

Autoimmune thyroid disease with goitre is Hashimoto’s

Autoimmune thyroid disease without goitre is Ord’s thyroiditis.

Both are autoimmune and generally called Hashimoto’s.

Hashimoto’s frequently starts with short hyperthyroid symptoms and results before becoming increasingly hypothyroid

Can be misdiagnosed as Graves’ disease (autoimmune hyperthyroid) if correct antibodies aren’t tested

To definitely rule out Graves’ disease you need TSI or Trab antibodies tested too

Only available as private blood draw via Medichecks

Graves Disease antibodies test

medichecks.com/products/tsh...

Low vitamin levels are extremely common with any, autoimmune thyroid disease, but especially when hypothyroid as this results in LOW stomach acid……then poor nutrient absorption and low vitamin levels as direct result

In U.K. medics hardly ever refer to autoimmune thyroid disease as Hashimoto’s (or Ord’s thyroiditis)

Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test

This gives highest TSH and most consistent results. (Patient to patient tip)

Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins

List of private testing options and money off codes

thyroiduk.org/getting-a-dia...

Medichecks Thyroid plus antibodies and vitamins

medichecks.com/products/adv...

Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins

bluehorizonbloodtests.co.uk...

Only do private testing early Monday or Tuesday morning.

Link about thyroid blood tests

thyroiduk.org/getting-a-dia...

Link about Hashimoto’s

thyroiduk.org/hypothyroid-b...

Symptoms of hypothyroidism

thyroiduk.org/wp-content/up...

Tips on how to do DIY finger prick test

healthunlocked.com/thyroidu...

Medichecks and BH also offer private blood draw at clinic near you, or private nurse to your own home…..for an extra fee

SlowDragon profile image
SlowDragonAdministrator

GP will often only prescribe to bring vitamin D levels to 50nmol.

Some areas will prescribe to bring levels to 75nmol or even 80nmol

leedsformulary.nhs.uk/docs/...

GP should advise on self supplementing if over 50nmol, but under 75nmol (but they rarely do)

mm.wirral.nhs.uk/document_u...

But improving vitamin D to around 80nmol or 100nmol by self supplementing may be better

pubmed.ncbi.nlm.nih.gov/218...

vitamindsociety.org/pdf/Vit...

Once you Improve level, very likely you will need on going maintenance dose to keep it there.

Test twice yearly via NHS private testing service when supplementing

vitamindtest.org.uk

Vitamin D mouth spray by Better You is very effective as it avoids poor gut function.

There’s a version made that also contains vitamin K2 Mk7.

One spray = 1000iu

amazon.co.uk/BetterYou-Dlux...

It’s trial and error what dose we need, with thyroid issues we frequently need higher dose than average

Vitamin D and thyroid disease

grassrootshealth.net/blog/t...

Vitamin D may prevent Autoimmune disease

newscientist.com/article/23...

Web links about taking important cofactors - magnesium and Vit K2-MK7

Magnesium best taken in the afternoon or evening, but must be four hours away from levothyroxine

betterbones.com/bone-nutrit...

medicalnewstoday.com/articl...

livescience.com/61866-magne...

sciencedaily.com/releases/2...

Vitamin K2 mk7

betterbones.com/bone-nutrit...

healthline.com/nutrition/vi...

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