will t3 at night interact with progesterone /magnesium?

[Knackeredandcross]

Evening all!

looking ahead, please can I ask if I take my second t3 before bed am I ok to take my progesterone, magnesium and vit d at the same time as I usually take them immediately before bed?

thank you in advance 🙏🏽

[Regenallotment Ambassador]

I’ve had to move Magnesium to after tea as someone kindly pointed out it was impacting my T4 split dose absorption when I took it at bedtime.

Not sure if the same is true for T3 🤷🏽‍♀️

I hadn’t thought about it previously because I was using magnesium cream topically which of course didn’t affect gut absorption.

My D3+K2 is drops / spray so absorbed in the cheek. That would be ok.

Can you get progesterone as a gel? Or have it vaginally?

Just ideas, I’m sure someone more experienced will be along 🌱

[Knackeredandcross in reply to Regenallotment]

we can’t get gel sadly and vaginally doesnt agree with me. im just wondering if there’s a minimum time required between them as it’s 4 hours for t4 🤔

[shaws Administrator]

I take my T3 once daily when I get up in the morning - with one glass of water and the rest of my day is normal. I have no symptoms and feel well and energetic.

I follow the advice by Dr John Lowe who was also an Adviser to Thyroiduk before his accidental death. He was an expert in the use of T3 especially for those who had resistance to other thyroid hormones. and he had been an Adviser to Thyroiduk.

Dr Lowe didn't agree with split doses as he stated that T3 saturated all of the T3 Receptor cells and that one dose sends out 'waves' that can last up to 3 days.

I trialled this - i.e. took my daily dose of T3 - took none on day 2 and day 3 and I was fine and had no extra symptoms.

drlowe.com/thyroidscience/c...

He would never prescribe levothyroxine - he did prescribe NDTs (natural dessicated thyroid and T3 ( liothyronine) for his patients who had 'resistance'.

We used to get NDTs prescribed in UK but they have now been stopped.

I hope you feel better soon.

[Knackeredandcross in reply to shaws]

thank you for this, that’s super interesting! My sister in law has just been diagnosed with fibromyalgia and when I saw her thyroid panel her t3 is at the bottom of the range but as her tsh is mid range I don’t see how she can get anywhere with her doctor 🤷🏼‍♀️

I only started my own t3 last week and was advised initially to add in an evening dose after two weeks before building up any further. Would you recommend just doubling the morning dose in this case rather than splitting?

[shaws Administrator in reply to Knackeredandcross]

Dr Lowe was a scientist/researcher and recommends T3 for those who have fibromyalgiia and he also took T3 himself.

I take my one daily dose when I awake with one glass of water and wait an hour before I eat.

I have a 'norma' life' by taking one daily dose per day as it saturates the T3 receptor cells and they, in turn, 'send out waves throughout the day.

Doctors are just doctors as I doubt many have training on 'how best to treat patients who have a dysfunctional thyroid gland'. I have had some nonsense made by a GP and I told him he was wrong and others couldn't diagnose me even with a TSH of 100.

The only time I've not had a good response to T3 was if there had been some change within the tablet.

[Jaydee1507 Administrator]

T3 isn't generally fussy unlike Levo. However, I would think it much better to keep magnesium 4 hours away from T3 as it can affect absorption of other things.

[Knackeredandcross in reply to Jaydee1507]

thank you 🙏🏽

[radd]

Knackeredandcross,

We shouldn't take our hormones with any other sups except for another hormone. Therefore , for a short time whilst thrice dosing T3 I took my night time progesterone with night time T3.

Magnesium risks binding hormones and Vit D should be taken with something containing fat so I take mine with breakfast. If you're taking magnesium to help you sleep, you could try taking it early evening. Ideally you would leave four hours between supplemented magnesium and hormones.

[Knackeredandcross in reply to radd]

thank you, yes - i use it for sleep so I’ll just take it earlier. Was your progesterone ok alongside the t3?

[radd in reply to Knackeredandcross]

Yes 👍.

[Pearlteapot]

I know a lot of people take T3 at night and there are good reasons for that; it helps them sleep and mirrors the circadian rhythm. However my consultant said it was pointless and a waste of a dose as t3 reaches peak an hour after taking it and is gone within 4 hours. On two doses a day that means having nothing in the afternoon and leads to afternoon or evening crashes. I can see the sense in that too. Just thought I’d mention this contrary view.

Following this advice also means I take magnesium at bedtime

[Knackeredandcross in reply to Pearlteapot]

thank you. I think I’ll maybe take the t3 around 4pm and then carry on with my nighttime routine and see how that goes as I do crash late evening.

[SeasideSusie Remembering in reply to Pearlteapot]

However my consultant said it was pointless and a waste of a dose as t3 reaches peak an hour after taking it and is gone within 4 hours.

What does s/he mean by "gone within 4 hours"? T3 peaks 2-4 hours after ingestion and it has a half life of between 19 hours and 2.5 days depending on which article you read but is mainly said to be 24 hours, so if I take 20mcg on Monday at 9am there will be 50% of that dose left on Tuesday at 9am, so it can't be "gone within 4 hours" if s/he means there is no T3 in your system 4 hours after ingestion 🤷‍♀️

[Pearlteapot in reply to SeasideSusie]

Perhaps, I’m speculating, he means that the effects of t3 on cognition etc are only effective while the dose is in its peak phase, which is why many people take split doses. The half life of t3 has a very long tail so that although half is still in the serum it is not effective against symptoms at that level. So when he says ‘completely gone’ he is referring the effect on symptoms being gone rather than the half life tail which is ineffective thyroidpatients.ca/2020/06/...

[jeanie245 in reply to SeasideSusie]

so do you feel then that taking T3 at 2am is okay? That is what I do. I wake up then and take it with water and go right back to sleep. I take levothyroxine then also. What is your opinion?

[SeasideSusie Remembering in reply to jeanie245]

I take my Levo plus one daily dose of T3 around 3-4am when I need the bathroom . I've done this for a long time . I tried splitting dose of T3 but it didn't make any difference for me. It suits me well enough, it might not be right for everyone .

[jeanie245 in reply to SeasideSusie]

thanks!!

[Noelnoel]

Interesting but since T3 is required for all sorts of processes (many that occur at night and during sleep), I wonder how accurate his/her assertion is

[Pearlteapot in reply to Noelnoel]

yes, I agree. I don’t know. I think if I was on a dose of 20 mcg and could take 5mcg at night I would. But on only 10mcg it leaves a long window through the afternoon and evening when I feel under medicated. Once my dose has stabilised and I’m not seeing the consultant regularly I may try night time dosing again. Not sure. Just thought I’d mention his view.

[Noelnoel in reply to Pearlteapot]

Yes and it’s always worth mentioning their views. Sometimes they’re right 😂

[Angel_of_the_North]

Mine seems to work OK about two hours after magnesium and about an hour after estrogen/progesterone/dhea, but I've always done it that way so I don't know if it could be better