Hello lovely people I wonder if you can help, I was diagnosed with Subclinical Hypothyroidism in September 2019, started on 25 mg and have slowly been increased to 125mg. I'm trying to understand if my Antibodies which keep rising have a part to play with still feeling very tired, fatigued and bizarrely when out walking the tops of my legs feel like I have a ton weight attached to them, they are ok when walking on the flat or downhill.
I've attached a screenshot of my last 3 tests from Medichecks, hopefully for ease I've noted the date against the TSH result and as you can see my thyroglubuin has increased each time.
I also have an intermittent thick feeling in my throat, again not sure if this is due to the high Antibodies?
Doctors as normal only check TSH and I follow the advice on here regarding taking the test on an empty stomach, at the same time etc, I take Mercury Pharma 100 + 25 mg each morning 1 hour before anything to eat or drink.
I have a face to face doctors appointment on the 9th Feb to discuss hopefully getting them to test everything, not sure if I need T3?
Hope this all makes sense, thank you in advance for any help greatfully received.
4th March 21' TSH 3.4
17th March 22' TSH 1.5
23rd November 22' TSH 0.7
Many thanks.
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YorkshireLass_1964
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Do you always get same brand levothyroxine at each prescription
High thyroid antibodies confirms autoimmune thyroid disease also called Hashimoto’s
About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high thyroid antibodies
Autoimmune thyroid disease with goitre is Hashimoto’s
Autoimmune thyroid disease without goitre is Ord’s thyroiditis.
Both are autoimmune and generally called Hashimoto’s.
Low vitamin levels are extremely common when hypothyroid, especially with autoimmune thyroid disease (Hashimoto’s or Ord’s thyroiditis)
Have you had vitamin D, folate, ferritin and B12 levels tested
What vitamin supplements are you currently taking
Your Ft3 is very low
Suggests poor conversion rate of Ft4 to Ft3……very common when vitamins are low
I've attached a screenshot of my last 3 tests from Medichecks, hopefully for ease I've noted the date against the TSH result and as you can see my thyroglubuin has increased each time
Actually……..TPO and TG antibodies are slowly dropping
TG antibodies tend to drop as TSH reduces
TPO antibodies often reduce on strictly gluten free diet/dairy free diet
Have you had coeliac blood test done yet…..if not request GP do so (as per NICE Guidelines) BEFORE considering cutting gluten out
Its been a struggle but I do get the same brand, I now have it printed on my prescription that I have Mercury Pharma, I managed this through reading information on this site and a very helpful independent pharmacist who was sympathetic to my request as his father had Hypothyroidism, I know for the past year or so I have been very lucky.
I don't think I have a goiter or I certainly can't see one, I'm not sure if the feeling in my throat suggests there may be the start of one? I'm assuming a scan would have to be done to confirm one way or the other if its Hashimoto's or Ords?
**Latest results 22nd November 22
Vitamin D - 109 nmol/L [50 - 200]
Folate - 9.15 ug/L [3.89 - 19.45]
Ferritin - 313 ug/L [13 - 150]
B12 - 110 pmol/L [37.5 - 150]
Coeliac test was negative, so I am starting the transition to gluten free to see if that helps.
**Daily supplements
1 x Bimuno for gut health
1 x B complex
Better You Vitamin D MK2 at night
2 x Brazil nuts for Selenium
I also take 80mg of Propranolol for migraine prevention, this at least has been life changing after a 30 year struggle, been taking this since Aug 22.
As T3 indicates I'm a poor converter do I need to talk to the doctor regarding possible T3 supplementation?
I take 80mg slow release propranolol once a day, is there an alternative brand that perhaps doesn't affect the conversion that you know of, I've had migraines for nearly 40yrs and this medication has been a life changing event for me, the thought of having migraines again fills me with fear beyond belief.
Sorry I forgot to list it, I use Better You magnesium spray at night.
Thank you once again for the information, I will have the full range of testing done again as advised, I will also ask the doctor to do full testing when I have my appointment on 9th Feb, see how I get on with that one! although you never know I may be surprised and they'll agree to my request 🤞🤞
We have received further information the lab about ferritin reference ranges. They confirm that they are sex dependent up to the age of 60, then beyond the age of 60 the reference range is the same for both sexes:
Males 16-60: 30-400 ug/L
Female's: 16-60: 30-150
Both >60: 30-650
The lower limit of 30 ug/L is in accordance with the updated NICE guidance and the upper limits are in accordance with guidance from the Association of Clinical Biochemists. ‘
Thank you for the information, yes I am post menopause 58yrs old, I will discuss the low Ft3 and high Ft4 with the doctor and try and get her to accept its due to taking propranolol.
I did ask the doctor who prescribed it if it would affect anything and he said no, I shouldn't be surprised at that as I'm beginning to understand they know very little about the Thyroid and interaction with other medication!
I've also read your profile which is very interesting, I must write mine!
Including 2 Professors at leading endocrine “centres of excellence”
Not one of them considered propranolol was an issue
Yet a 5 second google search will bring up numerous research papers showing propranolol reduces conversion, slows uptake and lowers Parathyroid levels (leading to low vitamin D, low magnesium and poor bone health)
When I experimented with increasing propranolol dose to 80mg it was twice as bad…..like wading through treacle
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Why would Antibodies rise on levothyroxine?
Should I be concerned?
Should I be concerned? T4 is out of range FT3 near top of range.
should I be concerned 
Should I be concerned?
