Thematic Issue: Thyroid Disease 2022

[helvella]

Can't remember which of these papers has been posted, or not, in the past.

Regardless, it serves as a reminder!

Thematic Issue: Thyroid Disease 2022

November 2022

Read our special collection of journal articles, published in 2021-2022, focused on the thyroid! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.

In Endocrinology, Liu and colleagues ( academic.oup.com/endo/artic... )report an association between free thyroxine and both birth weight and birth weight discordance in twins. Brûlé and coauthors ( academic.oup.com/endo/artic... ) describe results with mice indicating that IGSF1 loss can impair production of thyroid-stimulating hormone independently of alterations in thyroid hormone-releasing hormone levels or thyroid hormone action. Halada and coauthors ( academic.oup.com/endo/artic... )discuss hormonal crosstalk between thyroid cancer and breast cancer and its implications for future therapies.

In JCEM, Wu and associates ( academic.oup.com/jcem/artic... ) report that subclinical hypothyroidism is associated with incident metabolic syndrome in young men. Ettleson et al. ( academic.oup.com/jcem/artic... ) describe results suggesting suboptimal treatment of hypothyroidism is associated with worse hospital outcomes. And Krieger and colleagues ( academic.oup.com/jcem/artic... ) used orbital fibroblasts from patients with thyroid eye disease to demonstrate a likely mechanism of action of teprotumumab.

In Journal of the Endocrine Society, Jurado-Flores and coauthors ( academic.oup.com/jes/articl... ) describe in a mini-review the pathophysiology of neuropsychiatric manifestations of thyroid disease, the understanding of which they suggest could help identify novel therapeutic targets for patients with neuropsychiatric disorders. Caetano et al. ( academic.oup.com/jes/articl... ) report that in a small group of patients with nonmedullary thyroid cancer, metformin caused a decrease in serum thyroglobulin, a surrogate marker for cancer burden. The effect was independent of levels of thyroid-stimulating hormone. Polavarapu and others ( academic.oup.com/jes/articl... ) find that use of Afirma’s Genomic Sequencing Classifier can lead to a lower rate of surgeries and a higher malignancy rate in patients who do have surgery for cytologically indeterminate thyroid nodules.

In Endocrine Reviews, Jonklaas ( academic.oup.com/edrv/artic... ) discusses the subtleties of optimal thyroid hormone replacement, including the possible use of liothyronine in addition to levothyroxine. Andersson and Braegger ( academic.oup.com/edrv/artic... ) review iodine nutrition and its association with thyroid function in lactating women, infants, and toddlers. And Van Iersel and associates ( academic.oup.com/edrv/artic... ) describe recommendations for endocrine surveillance of childhood and young adult cancer survivors, who are at risk of developing malignancies as a result of toxic therapies; about 10 percent of these malignancies involve the thyroid.

Apparently open online access:

academic.oup.com/endocrines...

[Delgor]

Thank you so much hellvella for bringing these papers to my attention. The hormonal cross talk between thyroid and breast cancer was very illuminating as I had always felt that there must be a connection for my having bc following on from my thyroid going overactive and now here it is in writing that hyperthyroidism in particular is associated with increased risk of bc. Another part of the jigsaw now in place so thank you!

[helvella Administrator Thyroid UK in reply to Delgor]

I know some of these things are only being discovered and put together as we are living them, but there seems very little appreciation of the benefits of patient understanding.

So many on this and other forums seem to find something special from putting their stories together. (Even if only inside their heads.)

[Delgor in reply to helvella]

That is so true! So many things that I didn't know but thanks to the wonderful people on this forum I am learning. I feel I could write a book on all the things I've been through because of either being over-active or under-active but realise so many on here have been through the same or even worse! 👍

[Regenallotment in reply to helvella]

totally agree with this, there is the old adage that information in the wrong hands is dangerous, which I am sure my GP will quote at me at some point. However, I find it immensely comforting to have validation via scientific papers and to know I’m not an anomaly. Thanks for sharing 💚