Comparative Effectiveness of Levothyroxine, Des... - Thyroid UK

Thyroid UK

141,242 members166,488 posts

Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.....a study

DippyDame profile image
5 Replies

Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism

academic.oup.com/jcem/artic...

The rationale behind thyroid hormone replacement therapy is to administer thyroid hormone in a way that restores thyroid hormone signaling in all tissues.

There it is in black and white!

When will they stop focussing on TSH which is causing problems for many people

In conclusion, some patients on LT4 therapy remain symptomatic despite normal serum TSH levels. In the present investigation, the number of these patients was not sufficiently large to affect the outcomes of the whole group. However, in the subset analysis, these patients were identified as having the worst performance on QoL questionnaires and cognitive tests. These patients were also the ones that preferred and benefitted from switching to therapy containing T3, either DTE or LT4 + LT3 combination, suggesting that thyroid hormone signaling in a minority of the patients on LT4 remain subnormal and can be improved (perhaps restored) with therapy containing T3.

[Published in: The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021 ]

Written by
DippyDame profile image
DippyDame
To view profiles and participate in discussions please or .
Read more about...
5 Replies
helvella profile image
helvellaAdministrator

Indeed!

Highly relevant and important. And posted on a few threads.

It's here at last: a comparison of T4, T4-T3 combination therapy and DTE (NDT) - fuel for using against sceptical doctors/endos

healthunlocked.com/thyroidu...

Comment on earlier Bianco study

healthunlocked.com/thyroidu...

Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism

healthunlocked.com/thyroidu...

Reply to queries on paper by Bianco et al

healthunlocked.com/thyroidu...

DippyDame profile image
DippyDame in reply tohelvella

It popped up on my FB page this morning, posted by Paul Robinson.

Interesting threads

"When will they ever learn...."

Regenallotment profile image
RegenallotmentAmbassador

👏 nice to see it written so clearly!!

RedApple profile image
RedAppleAdministrator

DD, I have edited your main post to add the Journal and Publication date (The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021), just to clarify that this is not a new article. 😊

DippyDame profile image
DippyDame in reply toRedApple

Good idea...

Not what you're looking for?

You may also like...

Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism

Another interesting paper (and letters), supporting use of T3 - both synthetic and as desiccated...
helvella profile image
Administrator

Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?

Not yet even glanced - so no comments! Are We Restoring Thyroid Hormone Signaling in...
helvella profile image
Administrator

Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis

Evidence of the need for T3, in at least some hypothyroid patients, seems to be pouring in these...
helvella profile image
Administrator

Liothyronine Improves Biochemical Control of Congenital Hypothyroidism in Patients with Central Resistance to Thyroid Hormone

Rather than "Larger prospective studies are needed to confirm these findings and to determine the...
helvella profile image
Administrator

NDT and T3 use given support by US workers

This publication just out in Thyroid journal discusses using NDT (DTE) and T3 in suitable...
diogenes profile image
Remembering