Looking back I see in 2018 you were taking 50mcg or 75mcg T4 with 6.25,cg T3 :
Did you feel better than then and has the LDN helped in any way and do you plan to continue with Low Dose Naltrexone ? ?
You now take 25mcg T3 plus Thyrovanz :
The issue is we have no way of knowing the actual content of T3 or T4 in Thyrovanz :
How are your levels of ferritin, folate, B12 and vitamin D as these need to be maintained at optimal levels for any thyroid hormone replacement to work well ?
Are you with a thyroid AI disease ?
I read the average person needs around 50 T3 daily function :
1 grain Thyroid S contains 9mcg T3 + 38mcg T4 :
Do you have any current blood tests results and ranges to share with forum members ?
I do not know how long Thyrovanz takes to fully leave the body but the T3 should be fully gone in around 4/5 days so I think you could start on 1 grain - taken first thing in the morning as when you currently take your T3 and just stay on this dose for a few weeks :
Monitor your blood pressure, pulse and temperature twice a daily together with symptoms, and plot these levels and see if a pattern evolves :
Some people split the NDT - others don't :
Slowly increase in 1/4 grains every week and if you get to 2 grains - take a blood tests then as we should then compare this to your bench mark numbers taken before you started this experiment.
Your TSH will likely be suppressed/low - your T4 likely low, but your T3 should be proportionately higher - if well and symptoms are reducing but not resolved slowly starting nudging up y 1/4 grain increments.
There will come a week when you have gone too far and feel edgey and uncomfortable in your skin, so just drop back to the previous weeks dose and stay there letting this dose bed in for around 6-8 weeks and then take a blood test to see where your levels then sit.
I found my blood pressure and pulse remained constant but that my temperature rose from 35.4 to 36.6 where it tends to hover most days now, over 4 years later and still on the same dose.
I'm with Graves Disease post RAI thyroid ablation back in 2005 and managing lingering Graves, thyroid eye disease - caused by the RAI - and hypothyroidism.
I was still writing when you posted this, as I needed to lookback a bit at your history - read through again as I don't think you read the completed version.
Yes I have inflammation. Alot of boils especially around my chest area and on my scalp. I'm not on any form of iron tablets so the results are definitely from inflammation.
Thyrovanz took away the daily headaches i suffer from. Its not as debilitating as it used to be so something in it was working I guess.
Actually that day I didn't take my t3 at 5am as I was getting a SST done, so my last dose of meds was Thyrovanz at 6pm.
It stated t3 so I thought it was the t3 test and not free t3. Thnxs for the clarification. Hope your health improves with this addition. If I was in your shoes I'd add 12.5 of t4 ti help with your low level
So, there are several conversion charts suggesting how much everything is worth - but nothing can allow for how your body appropriates and utilises / converts the T4 :
It is said that 1 grain NDT is around 100 T4 - if all things are equal - which we know is probably not correct - and just a ballpark.
It is said that T3 is around 3/4 times more powerful than T4 :
So, if 1 grain NDT is 9mcg T3 + 38mcg T4 - and we say T3 is 3 times more potent than
I think you should start with 1 grain and try taking your NDT all at once :
NDT is bound to thyroglobulin and takes much longer to be digested and circulate around the body and sometimes referred to as slow release and 1 dose can take you round a 24 hour clock:
T3 is initially much more powerful but not as long lasting in it's effectiveness and falls away after around a 12 hour period.
Your currently ' primed ' to read your body as you would do for dosing with T3.
Good morning - I hope you feel a bit better than yesterday :
Have you stopped the 2 doses of Thyrovanz now ?
The issue we have is that we do not know the measured dose content of Thyrovanz so have no idea how or what might be an appropriate replacement
I think you may find this week, if adjusting just to the 1 grain NDT you might have a bumpy landing - I hope not - but just concerned as to the Thyrovanz leaving your body as well as the T3 :
Enjoy and stay out of the sun - if you have any - or rhumba in the rain - if that's the other option - good, just concerned, don't overdo anything until we find a dose that carries you well through 24 hours 7 days a week.
So currently im on 1.5 grains of NDT since 21st of August and i can say i feel awful 😖.
First 3 / 4 days i feel okish then raised to 1.5 first two was again okish but now i feel terrible especially the headaches. Alot of head pressure, dry eyes and so tired.
So you are on 1 grain AM and 1 grain PM - and temperature it raised - so likely this is a little too much medication - adjustments should be by 1/4 grains - up or down - so stay on 1+ 3/4 grains for 6-8 weeks and then run blood test .
Do you feel better for splitting the dose ?
I didn't know LDN took away afternoon naps - I thought it was more about reducing pain, inflammation and autoimmunity.
Are you gluten free and have you been checked for celiac disease ?
As you have Hashimoto's I wonder if you are also suffering with absorption issues and read of many with this AI disease having to heal their gut before finding their optimum dose of thyroid hormone replacement.
thyroidpharmacist.com will help with your understanding pf Hashimoto's AI disease - as my knowledge is limited as I'm with Graves post RAI thyroid ablation.
So in this past month you have stopped 25 mcg T3 and 2x Thyrovanz on which you were not well and switched to NDT with a dose that was 1 grain - worked up to 2 grains and now back down on 1 + 1/2 grains and with no relief of symptoms,
Considering the average person is said to need around 50 T3 daily just to function I tend to think you were undermedicated on the T3 / Thyrovanz and presumable still are on the NDT.
The other issue with Hashimoto's is that you are liable to erratic own thyroid hormone production and people experience swings in their symptoms to hyper and then back down to hypo as the thyroid is attacked and disabled by this auto immune disease so maybe it's not an even playing field while your own thyroid levels are somewhat volatile.
Looking back it seems this situation happens irrespective of what you are taking in the way of thyroid hormone replacement :
Did you go for the follow up tests as mentioned in a separate post from you around 24 days ago which didn't receive any answers - was this for cortisol, and adrenal function, can't look back and quote you now, as I 'll loose this question ?
Ok - so have you had this appointment now for ADR, COR and ACTH and what if anything has been said or done ?
I followed this guide but I was on Levothyroxine only and I reduced Levo by 25mcg as I added 1/4 grain thyroid S. not sure how this would fit with taking t3 though except going very slowly in small increments
Improvements were dramatic and very fast ie I felt hugely better within a day of my first dose of NDT. I had felt like a shadow no longer a complete person just a thing. I can only liken it to a jigsaw puzzle with a piece missing that the NDT suddenly put back in place and I felt whole again. I no longer felt two dimensional in a dreary miserable life not worth living. The colour came back and the misery lifted. It was not like completely back to normal in 24hrs, but the very worst things improved noticeably. I’d say within a month I felt like a new person and after two better than I did long before that as I probably had symptoms of thyroid disorder for decades. The depression that had plagued me all my adult life simple evaporated so that is a lot better than I ever could have expected. I assume all this was because of inadequate free t3 that the NDT restored to good levels. I think it varies greatly with how soon you see improvements. I am superfast reactor to medications according to 23&me which would fit with my experience with NDT and other medicine….bar Levothyroxine which never made me feel better and after two years on the stuff, left me fat, brain dead and suicidal.
I hope the NDT is as successful for you as it has been for me - it’s been a lifesaver.
Wow, so happy reading this (bought tears to my eyes) so glad it's worked for you.
I still have all those feelings you described. Just can't see the light at the end of the tunnel in any situation. My family think I over react to everything.
I have a feeling of being doomed.
T3 has helped but seems like it hasn't helped enough if I still feel like this kind of life is not worth living.
They can’t know what it’s like with this thyroid milarky only we do, so I sympathise with you. You probably need a better balance of T3 which should remove all those horrible symptoms like the doom feeling and life being almost unbearable. I just take NDT. I was on 1.25 grains for about 5 years and suddenly I needed to take more no idea why. I now take 2 grains but sometimes drop it to 1.75 if I feel a bit over the top. My ThyoidS is out if date now so may not be as strong as it ought to be, but it’s not bad! I managed to run 5 miles today to soak up the last of the heatwave - slow but steady 😊 so it’s definitely doing a reasonable job of powering me on as I have no thyroid function. It frazzled up to a crisp.
I hope you find improvements coming in due course. I was lucky that mine were so dramatic but not everyone experiences it like that and it’s far more gradual. Fingers crossed for you 🤞🏽🤞🏽🤞🏽
I ought to add that I needed to spilt my NDT dose initially or I felt weird but after a year or so I tried one dose a day of NDT and it was fine
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