Anyone faced any side effects with Thybon. I was prescribed it recently by my doctor. Intake 20mcg Thybon along with 75mcg levothyroxine. I have started getting a really bitter/ metallic taste in my mouth and my weight hasnt shown any change.
Anyone else experience similar side effects?
Post from 25 days ago healthunlocked.com/thyroidu...
Where you appeared to only be on 25mcg levothyroxine
Bloods showed you were very under medicated and needed dose increase in levothyroxine and having bloods retested in Dec
TSH - 1mu/l (range is .27-4.2)
Serum free T4 - 11.1 pmol/L (range is 10.8-25.5)
Serum free T3 - 3.3pmol/L (range is 3.1-6.8).
T3 should only be started as last resort once levothyroxine has been fine tuned and all four vitamins optimal
T3 should only be started EXTREMELY slowly. Adding just 5mcg and wait at least a week before adding 2nd dose
Retesting 6-8 weeks later
I was prescribed it recently by my doctor.
How recently ?
Thyroid hormone treatment is a very slow process.
And there does not seem to have been enough time gone by for you to have even got a set of blood tests done on 75mcg Levo+20mcg T3 , let alone expect any weight loss.
Once you are on the correct dose of thyroid hormones for your needs, then some weight loss may eventually occur naturally once your body's systems start to work optimally again.
....
But... your body's systems will not know what's hit them.... because you were only taking 25mcg Levo (+iodine supplement ?) and now have added a quite large dose of T3 at the same time as increasing Levo to 75mcg.
So you can expect your body to take a long while to adjust to what you 've done before it can become stable and allow you to lose weight naturally.
....
If you feel unwell now it will be hard to tell if it is because of too much , or too little hormone, because if you increase doses too quickly. You can miss the 'sweet spot' where your body works best.
If you are experiencing any odd effects , rather than thinking about 'side effects' i would first think that maybe you are taking more T3 than you need , (if you need to take any at all)
guidelines on dose levothyroxine by weight
Even if we don’t start on full replacement dose, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until on, or near full replacement dose
Getting levothyroxine dose increased up BEFORE considering adding T3
NICE guidelines on full replacement dose
nice.org.uk/guidance/ng145/...
1.3.6
Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.
Also here
cks.nice.org.uk/topics/hypo...
gp-update.co.uk/Latest-Upda...
Traditionally we have tended to start patients on a low dose of levothyroxine and titrate it up over a period of months.
RCT evidence suggests that for the majority of patients this is not necessary and may waste resources.
For patients aged >60y or with ischaemic heart disease, start levothyroxine at 25–50μg daily and titrate up every 3 to 6 weeks as tolerated.
For ALL other patients start at full replacement dose. For most this will equate to 1.6 μg/kg/day (approximately 100μg for a 60kg woman and 125μg for a 75kg man).
If you are starting treatment for subclinical hypothyroidism, this article advises starting at a dose close to the full treatment dose on the basis that it is difficult to assess symptom response unless a therapeutic dose has been trialled.
A small Dutch double-blind cross-over study (ArchIntMed 2010;170:1996) demonstrated that night time rather than morning dosing improved TSH suppression and free T4 measurements, but made no difference to subjective wellbeing. It is reasonable to take levothyroxine at night rather than in the morning, especially for individuals who do not eat late at night.
BMJ also clear on dose required
Thanks all for all your responses. I am only going by what the doctor has prescribed so rather confused.
Unfortunately , a huge amount of Doctors are just no good at adjusting thyroid hormones with enough care to find the right dose for an individual. Even the ones who say they specialise in it .We see useless , heavy handed, dose adjustment's on here every day, suggested by Doctors and Endocrinologists.
I've been reading this forum daily for about a year, and i'm my opinion , the combined experience and advice you will find here is far superior to that which most Doctors will give you.
The more you can understand the condition and treatment for yourself, the better results you will get , and you will come to know instinctively when advice from a doctor on thyroid hormone dose is incorrect.
It seems impossible to get your head round at first , but reading old posts from others on here in a similar situation as yourself will help, , and it does get easier to understand.
I would advise that next time a doctor advises a dose change , post it here and see what folk reply... it may save you months of feeling rubbish, and will give you the right questions to ask the doctor 
Best Wishes
Tat.
Many thanks Tat. This advice has been so welcome.I am seeing the doctor next week and will seek advice from the forum based on what they say /ask em to do next .
You're welcome Also make sure you get them to give you the actual blood test results.
most recent ones (and older ones are very enlightening)
You need to ask for;
TSH (Thyroid Stimulating Hormone) 0.00 [?-?]
fT4 (free T4) 0.00 [?-?]
fT3 (free T3) 0.00 [?-?]
The [?-?] are the lab reference ranges , they come with the test results , and the results are useless without them.
These are quite simple to interpret once you know how , and that is all the doctors do, and hopefully they take symptoms into account too, but so many of them only look at the TSH, and don't look at you at all ...
TSH is actually just a message from the pituitary to the thyroid to ask for more or less thyroid hormones (T4 &T3) to be produced.
When our thyroid can no longer produce enough hormone in response, then we are prescribed Levo (T4) and sometimes T3 as well.
Many doctors just look at TSH to see if it's asking for more or less, but there are several problems with only looking at TSH. Which is part of the reason they get dose wrong so often .
T4 is a 'storage' version of the thyroid hormone, it has to be turned into T3 in the cells before it can be used . The thyroid gland produces mostly T4 and a bit of T3.
T4 (and therefore Levo too) lasts about a week in the body, whereas T3 lasts only a couple of days , but is available immediately.
It helps to think of TSH and fT4/3 on opposite ends of a see saw,
When T4 and T3 go low , the TSH rises (to ask for more hormone)
When T4 and T3 go higher, the TSH falls (because you have enough , or too much hormone
Hope that helps , and doesn't just give you a headache
x
So you were on just 25mcg levothyroxine is that correct?
Then dose levothyroxine was increased to 75mcg in one go?
Levothyroxine should usually be increased slowly upwards in 25mcg steps
Which brand of levothyroxine are you currently taking
Have you always had same brand
Bloods should be retested 6-8 weeks after each dose increase in levothyroxine
Was T3 added at same time?
Too much, too quickly if so
Once levothyroxine is fine tuned and this can take several dose adjustments.........and all four vitamins need to be optimal....bloods should be retested 6-8 weeks later
If, at that point Ft3 still remains too low, then possibly adding small doses of T3 considered. Typically 5mcg twice day as starter dose and bloods retested 6-8 weeks later
Hello Slowdragon,
I was on 25mcg and then moved to 50mcg for 2 weeks before I moved to 75mcg and 20mcg of Thybon.
I have noticed no changes to my energy levels, weight etc. Perhaps a bit premature. But the only thing I have noticed is this terrible bitter taste since I started the new dose.
I was on cytomel a couple of years back but never had such a bad taste in the mouth. I had to stop it as couldn't afford to see the private endo anymore. Things started getting worse so have now gone back to her. This time round she prescribed Thybon as cytomel isnt easily available according to her...
Hopefully I get some answers from her next week.
Many thanks once again for all your help this far....
🙏🙏🙏
Should have been minimum 6 weeks before increasing to 75mcg
Then another 6-8 weeks on 75mcg and full bloods retested BEFORE considering adding T3
What vitamin supplements are you currently taking
Are you on strictly gluten free diet or dairy free diet
I am taking vitamin D, selenium, biotin, zinc and b complex. I am gluten free bit not dairy free. I was also taking vit A and iodine but based on some of the responses in this forum, I stopped taking vit A and iodine.
My 25mcg jump from 50 to 75 was made in 2 weeks.
I am going to see my endo next week so will.ask them about the sharp.increase in the dose.
Essential to stop all supplements that contain biotin a week before ALL BLOOD TESTS as biotin can falsely affect test results ...that will include vitamin B complex
When were vitamin D, folate, ferritin and B12 last tested
Are you splitting T3 into 2 or 3 smaller doses
Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water .
Last dose of Levothyroxine 24 hours prior to blood test. (taking delayed dose immediately after blood draw).
This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)
If/when also on T3, make sure to take last third or quarter of daily dose 8-12 hours prior to test, even if this means adjusting time or splitting of dose day before test
Recommend wearing a Fitbit or equivalent to record resting heart rate
I think my vitamin levels havent been tested in 8 months.
I am splitting T3 into 2 doses. I take ne with my levo in the morning and the other, late afternoon.
Noted points on no supplements a week before the tests plus Fitbit.
I will stop taking supplements as next bloods are next week when i see my doctor.
Many thanks once again!
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