Hi hav’nt Posted since Dec/Jan 2017/8 but have been seeing Endo for 15 months but going round in circles . I have had a blue horizons swab test and one of the results was increased D 102 activity does this men I don’t convert t4 to t3
Many thanks for any response
For clarity, the gene that affects T4 to T3 conversion is called DIO2 - that is, three letters and a number. Not D102 - a letter and three numbers.
The name comes from the enzyme that this gene affects which is a deiodinase. It removes an iodine atom from a thyroid hormone molecule - it deiodinates it.
On this forum we probably understand, but if you wish to look it up anywhere, it might help to get it right. If you are discussing with a doctor, and get it wrong, you are providing an excuse for them to dismiss what you say.
(More strictly, two single-nucleotide polymorphisms (SNPs) on the DIO2 gene, rs225014 and rs225015.)
academic.oup.com/jcem/artic...
The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:
en.wikipedia.org/wiki/Singl...
Many thanks for clarifying that the result I have is DlO2.
Did it say ‘increased DIO2 activity’?
Yes
Also says this has been shown to present as lower t4 and rt3 and higher t3 levels.adequate levels of iodine and selenium required for optimal functioning of this pathway.
Very confusing for me and if anyone can explain it would be much appreciated thank you.
Ooo I’m not sure that all sounds new to me. My DIO2 test showed ‘decreased’ activity meaning that I can’t optimally convert my T4 to T3.
I’ve not heard of it being’increased’ meaning higher T3. If you did have higher t3 is it too high?
This was a DNA swab test just says TT result is associated with increased DlO2 activity. Maybe someone else can explain, Thank you
Can you add image of results?
Did you get amber or red colour on DIO2 results
Blue Horizon DNA testing is not very easy to understand
Yes they are not easy to understand with that particular result it was TT GREEN
COMT RESULT RED AA Very slow(up to 4 times slower than the wild “GG” genotype) clearance of stress hormones and oestrogen. You may be at increased risk of thyroid disjunction when under stress due to poor elimination of oestrogen.
TRHR THYROTROPIN RELEASING HORMONE (TRH) Receptor Result GG
The “G” result has been associated with a less responsive negative feedback mechanism. Carriers of this genotype May show higher circulating TSH:T3/T4 ratio due to delayed reduction of TRH and TSH in the presence of healthy thyroid hormone levels. This may mean that the body is subjected to a less efficient response t
I changing thyroid hormone required.
I would had have had under active thyroid 30 years on 100 meg thyroxine and have appt with Endo Sept.
As you say very confusing-any help would be greatly appreciated thankyiy
So I think if result is green that means you do not have a problem with DIO2 gene
Any results that are orange mean heterozygous gene variation inherited from one parent
Red result means you have homozygous result inherited from both parents
Any other results red or orange?
Other posts that mention DNA
SlowDragon Can you help decipher for this poster?
A year ago you had low vitamins
healthunlocked.com/thyroidu...
Essential to retest vitamins at least annually - ideally more frequently until optimal and stable
When were these last tested?
Can you add most recent results for TSH, FT4 and FT3 plus both TPO and TG Thyroid antibodies
Plus vitamin D, folate, ferritin and B12
Vitamin levels need to be optimal
If you have raised antibodies this is Hashimoto’s
If you have Hashimotos low vitamin levels and gluten intolerance both extremely common
Private blood tests available
NHS rarely tests FT3 and refuses to test TG antibodies if TPO antibodies are negative
All thyroid tests should be done as early as possible in morning and fasting and last levothyroxine 24 hours prior to test
Yes I have had more tests but by Endo who I have seen 4 times since last year and I have not got those results, My gp raised my dose to 125 Mcg 3days of the week and I am to have a blood test next month for the go. I have been having B12 injections since last November as Endo wrote to GP.
Other remarks from DNA TEST are
TNF a inflammation AG ORANGE The A result increased likelihood of an over reactive inflammatory response. This means you are at increased risk of chronic inflammatory Hashimoto’s thyroiditis or Graves’ disease. It is important for you to minimise stress, and follow a healthy diet and excel use regime to manage risk.
TSHR RESULT GA ORANGE Remarks The A result has been found to be more common in people with Graves’ disease and is linked to the presence of thyroid stimulating hormone receptor antibodies (TRAb) associated with increased risk of developing GD.
TRHR GG RED REMARKS
The G result has been associated with less responsive negative feedback mechanism. Carriers of this genotype May show higher circulating TSH:T3/4 ratio due to delayed reduction of TRH and TSH in the presence of healthy thyroid levels. This may mean that the body is subjected to a less efficient response to changing thyroid hormone requirements.
Whew all double Dutch to me, any help please not seeing Endo til Sept.
May thanks
Will look at these later
You are legally entitled to your blood test results and ranges
Email endo secretary and request copies in post or by email
So it looks like TNF - amber - Heterozygous- means you are more likely, than average person, to get Hashimoto's or Graves
TSHR - amber - Heterozygous- more likely to have TRab antibodies if you have Graves' disease
TRHR - red - homozygous- so more likely than amber
Slow TSH response
Many thanks I will email endorsement and request copies of blood tests
When you get blood sets seeing Endocrinologist are tests as early as possible in morning and fasting and last Levothyroxine 24 hours prior to blood test?
How much Levothyroxine are you currently taking ?
Do you always get same brand of Levothyroxine at each prescription?
Many people find Levothyroxine brands are not interchangeable.
Once you find a brand that suits you, best to make sure to only get that one at each prescription. Watch out for brand change when dose is increased or at repeat prescription.
Many patients do NOT get on well with Teva brand of Levothyroxine. Though it is the only one for lactose intolerant patients
Always take Levo on empty stomach and then nothing apart from water for at least an hour after.
Many take Levothyroxine early morning, on waking, but it may be more convenient and possibly more effective taken at bedtime.
verywell.com/should-i-take-...
Other medication at least 2 hours away, some like HRT, iron, calcium, vitamin D or magnesium at least four hours away from Levothyroxine
Private tests are available. Thousands on here forced to do this as NHS often refuses to test FT3 or antibodies or all vitamins
thyroiduk.org.uk/tuk/testin...
Medichecks Thyroid plus ultra vitamin or Blue Horizon Thyroid plus eleven are the most popular choice. DIY finger prick test or option to pay extra for private blood draw. Both companies often have special offers, Medichecks usually have offers on Thursdays, Blue Horizon its more random
Previous posts show you were under treated and Levothyroxine disease too low at 100mcg
Plus your high antibodies confirm cause of hypothyroidism is due to autoimmune thyroid disease also called Hashimoto's
Hashimoto's affects the gut and leads to low stomach acid and then low vitamin levels
Low vitamin levels affect Thyroid hormone working
Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances. Most common by far is gluten. Dairy is second most common.
According to Izabella Wentz the Thyroid Pharmacist approx 5% with Hashimoto's are coeliac, but over 80% find gluten free diet helps, sometimes significantly. Either due to direct gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)
Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and slowly lower TPO antibodies
While still eating high gluten diet ask GP for coeliac blood test first or buy test online for under £20, just to rule it out first
Assuming test is negative you can immediately go on strictly gluten free diet
(If test is positive you will need to remain on high gluten diet until endoscopy, maximum 6 weeks wait officially)
Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse
chriskresser.com/the-gluten...
amymyersmd.com/2018/04/3-re...
thyroidpharmacist.com/artic...
scdlifestyle.com/2014/08/th...
drknews.com/changing-your-d...
restartmed.com/hashimotos-g...
healthcentral.com/article/t...
Other gut issues due to being hypothyroid
healthunlocked.com/thyroidu...
If you can't get results from endocrinologist, or not everything was tested, or tests weren't done early morning, fasting at last dose Levothyroxine 24 hours prior to blood tests.....then would strongly recommend you get FULL Thyroid and vitamin testing privately
D102 gene test 
D102 gene test &Nhs prescription 
Is D102 gene test necessary with good levels of T3? 
D102 test
D102 results 
