D102 gene test &Nhs prescription

[Simplyred57]

Does anyone know if I pay privately to to have the D102 test and it proves I’m not converting T4 to T3, would my GP be obliged to give me T3 on NHS?

[helvella Administrator Thyroid UK]

For clarity, the gene that affects T4 to T3 conversion is called DIO2 - that is, three letters and a number. Not D102 - a letter and three numbers.

The name comes from the enzyme that this gene affects which is a deiodinase. It removes an iodine atom from a thyroid hormone molecule - it deiodinates it.

On this forum we probably understand, but if you wish to look it up anywhere, it might help to get it right. If you are discussing with a doctor, and get it wrong, you are providing an excuse for them to dismiss what you say.

(More strictly, two single-nucleotide polymorphisms (SNPs) on the DIO2 gene, rs225014 and rs225015.)

academic.oup.com/jcem/artic...

The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:

en.wikipedia.org/wiki/Singl...

[JGBH in reply to helvella]

Thank you helvella to clarify this as it’s most important to be able to be aware and use correct terminology to fight our way with medical professionals who are often only too ready to dismiss our queries....

[SlowDragon Administrator]

A GP can not initiate prescribing T3. Clinical need must be diagnosed by an NHS endocrinologist in order to get NHS prescription

It depends also on which CCG area you are in.

Against guidelines some CCG are trying to say it's a blanket ban on T3 and pressurise NHS endocrinologist not to prescribe

Roughly where in the UK are you?

Email Thyroid UK for list of recommended thyroid specialists, some are T3 friendly and NHS

please email Dionne


[e-mail]

[Simplyred57 in reply to SlowDragon]

I’m in County Durham, I have the list already from Dionne, a member mentioned a GP can give you a private prescription for T3 is that not correct ? Obviously I would have to pay for the T3 thinking maybe the German pharmacy route I’d successfull.

[SlowDragon Administrator in reply to Simplyred57]

Well you can ask, but most GP's would be extremely reluctant

In part because they are in effect prescribing a non UK medication.

But a very few do agree to prescribe

[Quokka in reply to Simplyred57]

My GP writes me private prescriptions to buy T3 from Germany, but only because an endocrinologist first prescibed it a long time ago.

[SlowDragon Administrator in reply to Simplyred57]

One endocrine centre in Kent (Maidstone I think) is offering DIO2 test on NHS and NHS T3 prescription if you test positive.

More info in Improve Thyroid Treatment campaign on Facebook

Assuming you test positive push hard for NHS prescription

It's not at all clear if EU prescription options will remain available after March 29th next year

[trelemorele]

If your GP doesn't want to prescribe something (your case t3), it doesn't matter how much research or results you'll slap him over the head with, s/he will not prescribe - period.

I presented my GP with dio2 results and he point blank refused to prescribe t3, from questioning geneticist who signed it off credibility and calling my results "someone's opinion" to you don't need it, you have no conversion issues, it's too expensive.

[Lulu2red]

If you test positive ask your GP for a referral to NHS Endocrinologist; they cannot refute the scientific evidence so should prescribe but probably only T4/T3 combination. Then GP has to prescribe it ongoing. My GP told me I was very lucky to get a Consultant to prescribe, because he has been forced to transfer all his patients arriving from the EU on T3 back onto T4. However if you do not test positive you would have to go private or self medicate.

[Susieibbo301]

I saw a private endo in London who advised the D102 gene test and then with blood results and a positive gene result, referred back to my NHS GP who then prescribed T3 on the NHS. The Thyroid Uk research article on D102 is useful to take with you. There was no argument when a good endo recommended this.

[helvella Administrator Thyroid UK in reply to Susieibbo301]

I sincerely hope your endo DIDN't call it D102!

For clarity, the gene that affects T4 to T3 conversion is called DIO2 - that is, three letters and a number. Not D102 - a letter and three numbers.

The name comes from the enzyme that this gene affects which is a deiodinase. It removes an iodine atom from a thyroid hormone molecule - it deiodinates it.

On this forum we probably understand, but if you wish to look it up anywhere, it might help to get it right. If you are discussing with a doctor, and get it wrong, you are providing an excuse for them to dismiss what you say.

(More strictly, two single-nucleotide polymorphisms (SNPs) on the DIO2 gene, rs225014 and rs225015.)

academic.oup.com/jcem/artic...

The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:

en.wikipedia.org/wiki/Singl...

[Susieibbo301 in reply to helvella]

My mistake but my endo andGP knew all about it - so I am fortunate.