Gene D102

[Gcart]

Any thoughts on this poser .

If you have the D102 discovered at the stage when diagnosed would you have it before to your own thyroid hormone .

Would that explain why people feel troubles started well before diagnosis ?

[jimh111]

The DIO2 polymorphisms are just normal variations between individuals. If you have the polymorphism you are adapted to it, you use a little more T3 from the serum and convert a little less using D2. It's only if the thyroid packs in that you are at a minor disadvantage if you are not given T3.

[helvella Administrator]

For clarity, the gene that affects T4 to T3 conversion is called DIO2 - that is, three letters and a number. Not D102 - a letter and three numbers.

The name comes from the enzyme that this gene affects which is a deiodinase. It removes an iodine atom from a thyroid hormone molecule - it deiodinates it.

On this forum we probably understand, but if you wish to look it up anywhere, it might help to get it right. If you are discussing with a doctor, and get it wrong, you are providing an excuse for them to dismiss what you say.

(More strictly, two single-nucleotide polymorphisms (SNPs) on the DIO2 gene, rs225014 and rs225015.)

academic.oup.com/jcem/artic...

The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:

en.wikipedia.org/wiki/Singl...

[Gcart]

Thanks for the info I will need to read up but understand what you have posted. I don’t have that gene but always had low T3 to T4 and am now doing much better on NDT

[MaisieGray in reply to Gcart]

To clarify, it isn't that you don't have that gene, but whether you have a variant in that gene that may or may not negatively impact a particular process ie T4 to T3 conversion.

[Gcart]

Gosh its so complicated. I thought the gene pattern , not sure if thats the correct expression , easier for medics to treat patient correctly.