Query on thyroid resistance : Hello, My name is... - Thyroid UK

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Query on thyroid resistance

Manasi31 profile image
4 Replies

Hello, My name is Manasi Anawekar. I am a 46 years old perimenopausal woman with Hashimoto. I take T4 50mcg and T3 60mcg compounded thyroid, but not feeling better at all.

My current blood report is as follows :

T3: 2.66 (range 2.30-4.20)

T4: 0.87 (range 0.89-1.76)

TSH: 1.58 (range 0.35-5.50)

ANTI TPO : >1300.0 ( range <60.00)

Could you please help me find a solution to my problem?

Thank you

4 Replies
SlowDragon profile image

Your high antibodies confirm you have Hashimoto's

Essential to test vitamin D, folate, ferritin and B12. Always get actual results and ranges. Post results when you have them, members can advise

Hashimoto's affects the gut and leads to low stomach acid and then low vitamin levels

Low vitamin levels affect Thyroid hormone working

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances. Most common by far is gluten. Dairy is second most common.

According to Izabella Wentz the Thyroid Pharmacist approx 5% with Hashimoto's are coeliac, but over 80% find gluten free diet helps, sometimes significantly. Either due to direct gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and slowly lower TPO antibodies

Ideally ask GP for coeliac blood test first







All four Vitamin levels must be optimal, not just somewhere within range. Extremely common for these to be very low with Hashimoto's

Hashi-Monster profile image

As you are perimenopausal your progesterone might be too low and out of balance with your estrogen. This could be causing some thyroid resistance.

I use progesterone cream which helps with this problem.

shaws profile image

Welcome to our forum, and I am sorry you have Hypothyroidism (Hashimoto's) and your antibodies are high.

Thyroid Hormone Resistance means that the person cannot convert levothyroxine (T4) into sufficient T3.

T4 is an inactive hormone and has to convert to T3. T3 (liothyronine) is the Active thyroid hormone which is needed in the millions of T3 receptor cells in our body.

If someone is 'thyroid hormone resistant' they can only recover on T3 only. Their body isn't capable of converting T4 to T3.

Both T3 and T4 should be in the upper part of the ranges.

Advice when getting blood tests:-

All blood tests have to be at the very earliest possible, fasting (you can drink water) and allow a gap of 24 hours between last dose of hormones and the test and take afterwards.

Your antibodies are too high - which means you have a condition called Hashimoto's. Going gluten-free can help reduce them as the antibodies attack your thyroid gland and they wax and wane.

Blood tests for T3 and T4 are more informative when tested for Free T4 and Free T3 and I'll give a link for explanation:-


A Full Thyroid Function Test is:-

TSH, T4, T3, Free T4, Free T3 and antibodies.

I am not medically qualified but you need a higher dose to bring TSH to 1 or lower.

greygoose profile image

I don't think you have thyroid resistance. I think you have an absorption problem. Your levels are very low considering your dose. So, first question is, how do you take your thyroid hormone? Do you take it on an empty stomach and wait an hour before eating or drinking anything other than water? Do you take any other medication or supplements at the same time?

You're not feeling well because your FT3 is right at the bottom of the range, which is very strange on 60 mcg T3. :)

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