tsh resistance?

[Carlylouise90]

How strange is this? Had bloods done in October 2019 and my tsh was 29. It was 89 a few months before and levo brought it down. I haven't taken any Medication since it being 29 in October 19 because i was waiting to see a specialist as i had bad reactions to levo.. (tissue swelling in my ear, ear infections.. migranes.. dizziness veritgo balance problems brain zaps etc. my t3 and t4 have always been in range. t3 higher side and t4 lower side but never come out of range. i went and saw a endo on the nhs who prescibed me t3 and i ended up with severe chest pains and liquid levo that i got the same reaction to when i take the tablets.

gone private and My private endo has just sent me a letter saying my tsh is now 9. ive been on no meds at all!!

He said the professor at biochemistry said something is unusual as my t3 and t4 are constantly in range. TSH went wild after both births of my children. Had thryoidist last year so he thinks i have a tsh resistance. and the reaction i get is because ive got enough hormones in my body and than im putting more in!

So confused.

[SlowDragon Administrator]

diogenes knows something about abnormal TSH results...something to do with mice ?

He may pop along as I have tagged him....and explain

[Carlylouise90 in reply to SlowDragon]

mice? as in like mice.?? the little one things?

[SlowDragon Administrator in reply to Carlylouise90]

Something to do with mice 🐭 ....yes

[Carlylouise90 in reply to SlowDragon]

oh ok. ill wait for his message thanks x

[diogenes Remembering in reply to SlowDragon]

Two conundrums here. First one to consider: is the TSH test used susceptible to animal antibodies other than human: eg rats, mice,sheep etc. Quite a lot of people have antibodies of this sort in their blood, which can interfere with TSH measurements (usually too high). So first I'd check TSH with another method to rule this out. Second, if that does rule out artefacts, then some TSH resistance is quite a plausible idea.

[Carlylouise90 in reply to diogenes]

thats what my private endo has done. done a different test and sent it to a special hospital to make sure.. its come to 9... when it was 29 4 months ago. they are now diluting it.. no idea why.. t3 and t4 are in range.

[Carlylouise90 in reply to diogenes]

also i do have anitbodies of 200 plus.. for thryoid

[SlowDragon Administrator in reply to Carlylouise90]

Which thyroid antibodies?

thyroiduk.org.uk/tuk/about_...

[greygoose in reply to diogenes]

Can I just butt in here, please, to ask what TSH resistance is? I don't think I've ever heard of that, before. Thank you.

[diogenes Remembering in reply to greygoose]

It's when thyroid TSH receptors are partially blocked so that more TSH has to be produced to force proper output of T4 etc.

[diogenes Remembering in reply to greygoose]

In addition, some of the TSH is less bioactive, so more of the right TSH is needed - the TSH test will measure both sorts together.

[Carlylouise90 in reply to diogenes]

Serum thyroid peroxidase antibody concentration 288.4 ku/L [0.0 - 34.0]

endo mentioned i have a raised TPO antibody concentration and previously raised anti myeloperoxidase autoantibody

[Carlylouise90]

Serum thyroid peroxidase antibody concentration 288.4 ku/L [0.0 - 34.0]

endo mentioned one more was borderline

[HughH]

TSH is not a thyroid hormone so does not cause any hypothyroid or hyperthyroid symptoms. T3 is the active thyroid hormone which controls nearly every cell in the body and it is T3 which causes the hypothyroid or hyperthyroid symptoms. Free T3 is the best measure of T3 levels available for use by cells.

You seem to have hypothyroid symptoms so the Free T3 level which is the cause of your problems. Yours may be in range but some people need it to be high in range or even above range to feel well.