Has anyone tried taking NDT first thing in the morning and at bedtime? To me, that seems easier to remember than taking the second dose in the afternoon as is commonly recommended (for instance on the STTM), but maybe it's not a good idea to take T3 at bedtime...? I have decided to try to multi dose Thyroid-S as I seem unable to take as much as needed in one single dose without ending up with both hyper and hypo symptoms throughout the day.
Take NDT upon rising and at bedtime?: Has anyone... - Thyroid UK
Completely agree with Greygoose. I used to take a bedtime dose but for me it was a small one, larger doses due to the T3 content would keep me awake. There is nothing to stop you from experimenting with splitting the doses so that some can be bigger and others smaller if that helps you.
Now my b12 deficiency has been finally properly addressed I no longer need to do this but simply take my daily dose split in two, firsthing & lunchtime.
Hope you find the perfect splitting of doSes that is right for you. Keeping a little daily log may help to reflect back on what works best for you.