I've yet to have a diagnosis and wondering if someone can tell me what raised levels of TPO and TG antibodies could indicate.
I've also have PCOS which I've taken Metformin for years and i am now a pre diabetic.
I lost my 1st baby (Toby) after trying for 12 years at 5 months pregnant down to pprom and chorioamnionitis. Since then I've had investigations done and found out I had high TPO at 101 in January and was put on levothyroxine 50mcg by a miscarriage specialist as I went on to further miscarriages at early stages in Nov and Dec a few months after losing Toby.
After getting nowhere with my endocrinologist who said he wouldn't test me for autoimmune disease while I'm trying to conceive and after having my 4th miscarriages in may 2018 in a space of 14 months. I went to my GP requested a lot of tests. Most came back normal. But in this test I found out I had thyroglobulin antibodies 121 aswell as my TPO antibodies at 151.
Plasma viscosity was raised at 1.82 even though I take 150mg aspirin daily. Hba1c had gone up from 40 to 43 in a space of a few months from borderline prediabetic to prediabetic. Renal function is low at 84 & 88 (normal range is 90+). My 9am Cortisol levels was high at 819 (normal range is 200-500).
I went to see another endo for a second opinion and discharged me saying I don't know what you want me to do? She even hold her hands up to not knowing why I had thyroglobulin antibodies but asked me what they were , which I said I've read that both TPO and TG antibodies can be associated with hashimotos disease. She said only if thyroglobulin and other thyroid results are not normal she would test for thyroglobulin antibodies which said are a marker for cancer. She's busy asking me what I want her to do when she's supposed to be the doctor and should know what to do.
Today I've been to see GP to ask to be referred to a pioneering recurring miscarriage consultant Dr Shehata in Surrey. Which is a bit of a treck from Wigan but I really need to get to the bottom of my recurring miscarriages. Also asked for an scan on neck to check thyroid. My great Gran had a goitre on thyroid and she had it removed. My Gran has Alzheimer's Both from my Mum side of the family. My mum has had 8 kids and 2 miscarriages between the youngest 2 brothers. So fertility wasn't an issue for my mum.
Any advice or suggestions?
Thank you in advance.