DI02 test

[topaz1]

Is it worth doing this test if taking NDT? The Naturopath says I'm stuck. I'm also having trauma block counseling.

[shaws Administrator]

What does he/she mean with 'stuck'.

The following is from a doctor who only took a blood test for the initial diagnosis and thereafter it was all about how the patient felt on particular dose(s). Of course our vitamins/minerals had to be optimum too.

Dr Lowe would never prescribe levo only NDT or T3. He was also an Adviser to Thyroiduk.org.uk before his death.

web.archive.org/web/2010103...

web.archive.org/web/2010112...

[topaz1 in reply to shaws]

She has tried different medications on me that most people have reacted to but have had absolutely no effect on me. Same story with the homeopath.

[helvella Administrator Thyroid UK]

topaz1,

It is DIO2 - three letters and a number - not two letters and two numbers!

We understand but you might undermine your case if you get it wrong when discussing with a medic.

[Jazzw]

Shouldn’t that be, “The Naturopath is stuck”? Hardly see how it’s your fault!

Having had a peek at your previous posts and found some results, I don’t know that I’d bother. You seem to be doing ok on NDT. It might give you one more piece of information about whether you convert T4 to T3 well or not, but what difference would that make, really?

[marigold22]

For me personally, receiving a positive result from the DIO2 thyroid gene test, gave me a piece of paper to wave in front of my GP and an endo. It convinced them to let me have NHS T3. They didn't really understand the words on it (bless them) but with my assistance, it coerced the endo into doing what I wanted and needed. For me, it was well worth the £160. I've got that piece of paper for life now. By the way, the results came to me via internet, so I can continue to print out as many copies as I want.

[BlueHorizonMedicals]

Hi Topaz,

As marigold22 says it gives you a platform to approach your GP from, and more GPs nowadays ARE aware of the DIO2 implications..

Other genes and variants to consider are

DIO1 - Thyroid Hormone Activation

“D1” is largely expressed in the liver and kidneys. It is responsible for the clearance of rT3 from circulation, and for facilitating the conversion of T4 to T3 in plasma and surrounding tissue. This process requires selenium and iodine for optimum function. There are two variants linked to poor conversion of T4 to T3 andr educed clearance of RT3.

DIO2 - Thyroid Hormone Activation

“D2” is importantly expressed in the central nervous system, pituitary, brown fat tissue and muscle, and responds to changes in thyroid levels. D2 is responsible for the ‘local’ conversion of T4 to T3 in the thyroid, placenta and brain. It requires selenium and iodine to function optimally. There are two different variants linked to decreased T4 and low mood in certain individuals.

COMT - Inactivation of Stress Hormones and Oestrogen

COMT is one of the main inactivating enzymes of stress hormones and oestrogen in the body. COMT variants cause slow clearance of stress hormones and oestrogen leading to high oestrogen and stress hormone levels which may also be linked to thyroid hormone dysfunction.

FKBP5 - Cortisol Regulation

FKBP5 is an important stress-regulating gene responsible for lowering cortisol levels after a stress response. Variants are associated with prolonged and increased symptoms of stress, which may be due to delayed lowering of cortisol levels.

PDE8B - TSH Signalling

PDE8B is found in the thyroid but not the pituitary, and is involved in TSH signalling. It is thought that the variant decreases the response of the thyroid gland to TSH stimulation

TNF-a - Inflammation

TNF-a is an inflammatory cytokine that helps regulate the immune reaction involved in inflammation, giving rise to fever and inhibiting tumour growth. If poorly controlled, it may be implicated in a number of autoimmune disorders. Variants in TNFa are associated with overreactive immune responses and prolonged inflammation.

TSHR - Thyroid Stimulating Hormone (TSH) Receptor

The TSHR gene plays a central role in thyroid metabolism bycontrolling the thyroid gland’s receptivity to TSH. Variants in this gene have been linked to hyperthyroidism, particularly to Graves’ Disease (GD).

TRHR - Thyrotropin Releasing Hormone (TRH) Receptor

Responsible for the body’s receptivity to TRH which stimulates the secretion of TSH from the pituitary gland. In turn, TSH stimulates the production of thyroid hormones from the thyroid gland. TRH is an important part of the negative feedback loop that ultimately regulates thyroid hormone levels. Variants have been shown to affect TSH levels.

Best wishes,

Paul Harris

Blue Horizon Medicals

[topaz1]

Thank you so much for all that information. it has given me a lot to think about.