DI01/DI02 tests.

[Kathy1960]

I wish they had the offer for their DNA blue thyroid genetics again. I would love to know if I have a fault in my DI01/DI02 genes and saw there was a 50% off offer a while ago, now wish I went for it then. 😢

[jimh111]

The polymorphisms in DIO1 / DIO2 genes have minor effects and so wouldn't explain substantial symptoms, especially if you have restored normal fT3, fT4 levels. If these polymorphisms made a big difference the patient would be hypothyroid from a few months after conception.

[SlowDragon Administrator in reply to jimh111]

DIO2 only starts to have effect once a patient is prescribed Levothyroxine....because its only then that they are being asked to manage on only T4

Having DIO2 gene means your brain struggles to convert FT4 into FT3

Obviously when you have a normal fully functioning thyroid you are getting enough FT3 for brain from your own thyroid hormones

Bloods tests of a patient with DIO2 gene variation rarely shows low FT3, but adding small dose of T3 can give significant improvements

[Kathy1960 in reply to SlowDragon]

Thanks for your reply, I seam to be having problems converting T4 to T3. I’m on levo thyroxine 75mg now, was on 125 but lowered to 75 because I started taking Tiromel t3 I check my bloods quite often and my t3 levels had not changed at all when I was on T4 alone, my T3 levels stayed at the lower end of the scale not mater how much T4 I took so I was told I could have the faulty gene D102.

[jimh111 in reply to SlowDragon]

Yes, the original study found the DIO2 rs225014 polymorphism made no difference to serum fT3 but a later study found fT3 was 0.4 lower in subjects with the polymorphism from both parents. Thus, if you give just a little T3, enough to raise fT3 by 0.4 you have overcome the polymorphism. This doesn't seem to help most patients, this is why this polymorphism does not explain the servere symptoms many patients have. Certainly if patients have the rs225014 polymorphism from both parents they should be given a trial of a little L-T3 to see if it makes them better.

[SlowDragon Administrator]

The Regenerus one is MUCH easier to understand results

Blue Horizon test results are difficult to interpret

[SlowDragon Administrator]

Examples of Blue Horizon DNA results

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu......

Also it's actually DIO2 (letters) not D102 (numbers)

[Kathy1960 in reply to SlowDragon]

Thank you for these 👍🏻

[SlowDragon Administrator]

Presumably you mean this DIO2 test (not DIO1)

thyroiduk.org.uk/tuk/testin...

[jimh111]

This is very sensible. They tend to assume blood hormone is the only homeostasis mechanism when there are complex mechanisms that control the entry of hormone into cells and conversion to T3. Until there is a thorough understanding of these mechanisms (many decades away) they should go by empirical response to a trial of hormone.

[jimh111]

I would say that if they prescribe a dose of T3 that restores your normal fT3 levels from before your TT and you still feel awful then the problem would not be a DIO2 polymorphism. If you get better when the T3 your thyroid used to produce is prescribed then it probably was due to a DIO2 polymorphism. The important point is that if patients don't feel well some T3 should be prescribed.

[jimh111]

That's true, your pre-surgery levels are not reliable. If you are not better when your fT4 is a little above average and you need more than 10 - 20 mcg L-T3 then it won't be due to the polymorphism. Our thyroids secrete about 6 mcg but the thyroid also does some conversion hence my GUESS at 10 - 20 mcg being equivalent.