hey a quick question about this - since there are other factors that can affect conversion, for example oxidative stress having an impact on deoidinases, would I be right to think this test could come back negative, not inherited from either parent, and you could still have problems with conversion? i know i have conversion problems, i'm just still at the 'prove it' stages, especially because of my complex issues.
also if i were to do take this test, i'm aware of the companies who supply it, but is there any lab/company particular which endocrinologists are likely to take more seriously? for example are they likely to turn away results from a specific company since they come from 'functional' labs, even though it's genetic testing.
i know i have conversion problems
ta x
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perardua
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Thank you DippyDame for this and your past help, that's really all I need to know. Felt horrific on levo only in the past, also run my 'normal' results through the Spina-Thyr app which indicated poor conversion. And have had mould found in my system by functional medicine tests from a damp building i lived in, which causes oxidative stress and mould exposed people have responded positively only to combo or t3 only in studies. So enough for me to be fairly convinced.
Plus just because you have a specific issue in a gene sequence does not mean it is definitely causing problems.It has to be activated, so to speak (All scientists forgive my feeble choice of words). Otherwise people would be running screaming from their 23andme tests.
If your Spina results indicate poor conversion, you can trust this, but getting a Dr who understands/accepts it is something else.
I had DIO2 tested in 2015 and my Endo is still querying it, despite me being better on combination therapy for 6 years.
It may help to get a lab certificate from Regenerus, but there's no guarantee and it's expensive. So perhaps try without first of all and offer to undertake the test if necessary. It would at least tell you whether you are homozygous or heterozygous (inherited from both parents or just one).
‘since there are other factors that can affect conversion, for example oxidative stress having an impact on deoidinases, would I be right to think this test could come back negative, not inherited from either parent, and you could still have problems with conversion?’
Yes, exactly that, and as Litamon points out a DI02 genetic mutation only evidences increased risk of conversion issues and is not a guarantee, nor does it show the level of impairment.
Mould is known for influencing deidinase behaviours as will be putting your body under stress, so also possibly effecting adrenal health. You would be better addressing the mould issues rather than just adding T3 meds which would only act as a plaster for so long.
Conventional medicine isn't good at recognising endocrine damaging environmental factors and even less good at understanding thyroid enzyme genetic results.
... ...try taking levothyroxine in small doses (25 mcg max) 4hrs apart over 24 hrs until you reach the optimum total per day. the negative feedback of excess T4 slows down the rate of T4 - T3 conversion which can be even more significant for genetically poor converters or even the cause of poor conversion irrespective of DNA. Absorption of levothyroxine as affected by food and drink is a bloody big red herring and not as important as T4 homeostasis via feedback loops. Healthy human data shows that thyroidal T4 is drip fed by consistent pulsatile release 24/7. Medics would have you take it all at once on an empty stomach at 6am!!!!
I had a 23andMe test done which showed a polymorphism of the DIO2 gene. After also having a number of tests done showing high RT3, high T4 and very low T3, I decided to come off of Thyroxine which stopped regular migraines I had been having for a few years, so I won’t go back on it. But trying to get the endo to prescribe anything different is impossible (Ashford Hospital, Surrey). She has written ‘I have reviewed the literature on DIO2 affecting conversion of T4 to T3 and there is no evidence that this is the case and genetic testing is more a research tool). So, I guess after being under the endo for a year to try and at least get a trial of T3 med, I will have to go private.
Suggest you try and ensure any private endo you plan to see is on the ThyroidUk list....and then Post a question here asking to be PM'd feedback on anyone you feel might be of help to you?
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