Thyroid UK

New Endo taking stepwise approach as to whether I've got cushings ?

New Endo taking stepwise approach as to whether I've got cushings ?

Hi Everyone

I need a little advice if anyone with knowledge of Cushing s , high cortisol and adrenal insufficiency could offer any advice .

My saliva tests show very high cortisol my new NHS Endo has ignored these results and I've had dex suprresuon test and 48hr urine test no results as yet !!! I'm waiting for imaging as a last resort but she's so slow and doesn't plan to see me for 3-4 months !!!! to see if I've got anything causing this high cortisol and I'll health .

I can not sit around feeling this awful so I've been advised to start Adrenavive ll but reduced my Levo to 25mcg for a few weeks but the last 4 days I felt so tired and lethargic I was wondering if I should of stayed on 50mcg and slowly introduced the Adrenavive ll and then go into the Metavive l (thyroid) in a months time ? I feel so weak no energy at all ! My most recent test are

TSH 3.87(0.2-4.20)

FT4 14.2 (12-22)

Total Thyroxine 103. (59-154)

Free T3 4. 5 (3.10-6.80)

Thyroglobulin 257 (0-115)

TPO 406 (34)

Thankyou for any advice

Kazbe 😀

1 Reply


I'm sorry you've had no replies. Feel free to repost your questions about Cushings.

TSH 3.87 indicates you are undermedicated so you should resume taking 50mcg and retest 6-8 weeks later to check 50mcg dose is sufficient.

The goal of Levothyroxine is to restore the patient to euthyroid status. For most patients that will be when TSH is 0.3 - 1.0 with FT4 in the upper range. FT4 needs to be in the upper range in order that sufficient T3 is converted. Read Treatment Options in

Thyroid peroxidase and thyroglobulin antibodies are positive for autoimmune thyroid disease (Hashimoto's). There is no cure for Hashimoto's which causes 90% of hypothyroidism. Levothyroxine treatment is for the low thyroid levels it causes. Many people have found that 100% gluten-free diet is helpful in reducing Hashi flares, symptoms and eventually antibodies.

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