I have been on T3 only for 12 days, after 'washing out' NDT for four days. My doctor recommended a start dose of 15 mcg a.m. and 10 mcg p.m. I can't get over 10 mcg (5 a.m. and 5 p.m) without going hyper - my heart feels it is beating too fast and I am feeling shaky. I woke up this morning feeling like that, so today I haven't taken anything so far. I have been treating high cortisol with ashwagandha for over a year. Apart from this, I actually feel much better: more energy, better brain function, happier mood. I know everyone is different, but has anyone started on a dose of 5 mcg per day without going even more hypo and then were able to increase the dose? I tried T3 last year, but it was a disaster because I started too high and still had loads of T4 and possibly RT3 at the time. NDT has improved things, but I have not achieved optimal health and am still very symptomatic.