If NDT, T3 and combination therapy are causing such a high risk for bone loss and what not, how come it makes sense to prescripe following drugs to "FIX " failed thyroid treatment? Let alone gazillion of other drugs causing so many weird adverse reactions and side effects.
Wouldnt it mathematically,scientifically and -ally this and that make sense to REDUCE all possible risk factors by using just one type of potentially risky medication?
I know thyroid meds used correctly are no risk for anything else except patient becoming happy ,which is awful side effect... !!! Potential risk of bone loss is dodged by not taking too much of thyroid hormones. With other drugs you do not have that option! Which is easier to do? Tricky. Not.
Besides its hormone replacement. It is impossible and simply stupidity to try to achieve reasonable wellbeing by treating symptoms with other drugs, as ideally individually tailored thyroid hormone replacement will result in satisfying wellbeing.
There is no single evidence that usage of other drugs would work long term. 0 evidence. None. If anything there is ton loads of evidence that other drugs cause more harm long term.
T4 only group should be compared to group on other replacement (NDT/T3/combo) and compare how many other drugs are used , how many drugs became unnecessary once optimal treated.
Our review of 19 studies on the effect of SSRIs on bone indicates negative effects on BMD and/or heightened fracture risk. The explicit magnitude of this effect remains unclear due to the tempering effects of various potential confounds. However, in support of this relationship, there are known negative pathophysiological effects of serotonin on bone regulation. While no recommendations are presently available, SSRI use in high-risk individuals (e.g., those with osteoporosis, history of osteoporotic fractures) is cautioned.
Treatment with a PPI results in a significant reduction in bone density. Close monitoring is beneficial for patients who are to receive long-term treatment with PPI.