Have been working on low progesterone levels for a few years now and don't seem to be making much of a difference at least in regards to lab tests. Began with the Dr. Lee over the counter cream, then my dr. prescribed the compounding pharmacy higher dose. Was taking like 50mg -100mg a day on days 10-20 of my cycle. Has improved pms symptoms and much better cycles..a lot less bleeding. But tests still show quite low levels of progesterone. Dr. said to experiment and find out how much is right for me. But I read in some places not to take that much. Do some people need much higher doses becuz they don't absorb it as well or something? Any thoughts?