Neg ANA, positive TgAb, negative TPO: Hi guys... - Thyroid UK

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Neg ANA, positive TgAb, negative TPO

Hi guys,

Just got the ANA results which was negative. I haven't had a comment from my dr about it.

She stated previously she would be apprehensive to diagnose an autoimmune disease with a negative ANA... I have read somewhere that it is only about half the people with Hashimoto's that has positive ANA?

Or does this mean the possibility of Hashimoto's is less and leaning more towards a cancer diagnosis?

I am going to have an ultrasound of my thyroid on the 10th April - I assume to check for cancer, goitre and/or nodules.

Does that all make sense?

How would you interpret above?

(I have had lots of other test done - listed in previous post - mostly euthyroid with T3 below range once. Low on ferritin despite supplements)

Waiting time is frustrating.

Thanks all

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I had a positive ANA test yrs ago, but negative thyroid antibodies test each time the antibodies are tested. I repeated the ANA test at a later date and it came back negative. So I don't bother doing the thyroid antibodies test or the ANA test anymore. My lab tests are out of whack - with or without a positive or a negative result to my ANA and my thyroid antibodies. 🤔

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So base-line - I shouldn't put much weight into whether the ANA is positive or negative? It could be either?!

It's so frustrating not having a diagnose. I feel I can't do anything as nothing is for sure.

- thanks for your reply londinium :)

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Not much help as I don't think I've had an ANA test but I've tested positive for TgAb and negative for TPO but this still means hashimotos I was told x

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Thanks kjkla85.

It helps to know.

Feeling a little lost in the dark :)

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You can have Hashimoto's even without testing positive for the antibodies. I asked a professor of endocrinology and he said it was possible.

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Well - that doesn't make it any easier to get a diagnosis then 😜

I hope I can see a specialist next time I am on leave (I am a Dane, but live in Tanzania - not the best place to have any medical problems)

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Imagine you're told you have Hashimoto's and so you then follow a dietary protocol which improves your health. I'd suggest doing that. Otherwise, you may wait in vain, for several years, just like I did, thinking that some fool (aka a doctor) will correctly diagnose you.

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Hi ,just come across this post I too have positive Tgb antibodies but normal tpo antibodies ok so worried as I’ve read that you need vit antibodies raised for Hashimotos but Tgb antibodies alone can be something else I’m so worried what was the outcome of your high Tgb alone ? X

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Hello, nothing came out of it for me really. I did show the doctor my blood result previously and she said it just means it's autoimmune. I had another private test recently which still showed the TgB to be too high - over 100 I think but that's better than the almost 400 from before. I assume it's because my dose of levo is better!? Sorry not much help. I have moved so maybe when I have my next blood test at the doctors I will ask them and see what they have to say. Good luck

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Thanks so much for your reply,did you have a scan of thyroid? All my thyroid results are ok it’s jsut this Tgb antibodies that’s high it’s really worrying me x

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Oh right so are you on thyroid meds? My TSH was super high initially which was how I was diagnosed. I only found out about the antibodies through a medicheck test - the doctors didn't test that at all. I've never had a scan of my thyroid done. Have you spoken with the GP about the results? Do you know how high?

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Hi, no I’m not on any meds my thyroid test re were normal with my doctor it’s only because I paid privately through medichecks to have the antibodies tests and found my Tgb high ,I’m so worried about them being high as I’ve heard it can be cancer x

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My Tgb antibodies are 196 x

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My last check was 190 but the previous was 458 I think. I honestly don't know anything about it besides that it's autoimmune. I would imagine that means for you your thyroid results could get worse. I'm sure there's some research saying if you're having symptoms and have autoimmune disease that that in itself is an argument to take thyroid replacement tablets - I could be wrong. Perhaps post a new post on the forum asking for advice as there are some very knowledgeable people on this forum. I'd speak to your GP about the results if you are worried and are having symptoms for sure. Best wishes and let me know how you get on.

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Will do and thanks so much x

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Frustrating not having a diagnosis? Welcome to the club. All the diagnoses that I receive are incorrect. My GP looked at my FT3 result last month - it was outside of the reference range - and he claimed it was perfect. I gave him and all those other so-called doctors who I'd seen - who are nothing more than charlatans professing to be doctors - my trust for all those years.

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Hi Ive just come across your post, I too hadn’t found via private tests that I have just the Tgb antibodies high I’m so worried,whatbwas the outcome for you ? I hope you are well xx

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Hi, same here TgAb on Medichecks very high. No peroxidase ones. Thyroid function fine, well perhaps T4 little low. I was told you can have Levo to put your thyroid to sleep. Some people say a lot of people have TgAb. But on its own at a higher level, it’s an autoimmune disease. It does not mean you have cancer. However, cancer is linked to chronic inflammation like Crohn’s disease can lead to bowel cancer. This is in early stages of medical understanding. If I were you, I would look at the functional doctors people recommend on here for ways to get the antibodies down, like going gluten free and using supplements. I had an ultrasound and my thyroid is inflamed. Autoimmune thyroid disease is linked to cancer, but they aren’t sure how in medical circles. A lot of people told me they found out they had autoimmune when their thyroid was removed due to cancer. I believe my cancer came from the chronic inflammation. So I would work on your health. But thyroid cancer is fairly rare.

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Like cancer is a lot rarer than thyroid disease. So don’t be too worried, but all people with thyroid issues should check their neck for lumps. Women do not have Adam’s apples! The amount of blokes that I show my cancer to and they say, isn’t that just your Adam’s apple!??

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