Thyroid UK
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Borderline high globulin

Morning all

In my most recent blood test, my globulin came back as 31.2 (normal range 25 - 32). The albumin was 41, making an A/G ratio of 1.3, which also appears to be normal. Although it seems my lab uses different ranges to most I've found on the internet (most labs seem to have the upper value of globulin as 35), I was nevertheless wondering whether hashimotos (and/or hypo) could lead to higher levels of globulin.

I don't know if this has anything to do with it, but my anti thyroglobulin antibodies were quite high when I tested one year ago, as where my anti-tpo. Could it be that the serum globulin goes up when the anti-tg is elevated in the presence of hashis?


4 Replies


Thyroglobulin and serum globulin are different proteins. I can't see why levels of one will affect the other.

Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland.

Thyroglobulin - Wikipedia

What is serum globulin?

A total serum protein test measures the total amount of protein in the blood. It also measures the amounts of two major groups of proteins in the blood: albumin and globulin. Albumin is made mainly in the liver.

Total Serum Protein - WebMD

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Thanks for the info.

Do you believe a value of 31.2 could be due to hashis?

Would you consider this value to be concerning?




I doubt it has anything to do with Hashis. Thyroblobulin is about the thyroid and globulin is more about the liver. 31.2 is within range so there's nothing to be concerned about.

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Thank you for your assistance.


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