In spite of having read to the contrary on this learned site, I just wanted to say that I note no diminished effect if I take my Cynomel just before, during or after eating. I am presently taking 50 Levo at 6 AM and 62.5 Cynomel (T3) divided into four doses. In the PIL instructions for French Cynomel there is no mention of when or how to take it. And I am feeling good on this dosage. And I take it with coffee sometimes too!